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Jupiter in the eight house and lagna is Mesh.

Whether
Jupiter is responsible for joint pain? What will be remedial
part? PART-IX

Also you need to see depositions of Lord
Mangla to see where he puts dristi. Mars
dristi (via Bhava 4, 7, 8) on Shani if he is
deposited there (or to a lesser extent vice
versa dristi, 3, 7, 10 on Mangla/Ketu) in this
configuration may well give the fruits of
joint pain as Mangla and Shani are enemies.

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