AGEING PROCESS IN

THE EYE

Budu,M.D,Ph.D.
DERMATOCHALASI (BLEPHAROCHALASIS)
CORNEAL ARCUS
SENILE CATARACT
AGE RELATED MACULAR
DEGENERATION
(AMD)


LEADING CAUSE OF IRREVERSIBLE
BLINDNESS IN OLD PEOPLE
CLASSIFICATION :

DRY TYPE AND WET TYPE

DRY TYPE : DRUSEN
WET TYPE :
- EXUDATIVE RPE
- DETACHMENT
- NEOVASCULAR STAGE
INTERNATIONAN CLASSIFICATION BASED
ON CLINICAL MANIFESTATION:
* EARLY AMD : DRUSEN
* LATE AMD : GEOGRAPHIC ATROPHY
NEOVASCULARSTAGE


DRUSEN
LATE AMD WITH EXUDATE AND NEOVACULARISATION
RETINAL PEGMENT EPITHELIUM
SPECIALIZED FUNCTION TO SUSTAIN THE
PHOTORECEPTOR CELLS AND OUTER SEGMENT
RENEWAL

TO DISCHARGE CYTOPLASMIC MATERIAL TO THE INNER
PORTION OF BRUCHS MEMBRANE TO ACHIEVE
CYTOPLASMIC RENEWAL

RPE CHANGES WITH AGE ARE CHARACTERIZED BY THE
ACCUMULATION RESIDUAL BODIES (CONTAIN
LIPOFUSCIN) IN RPE CYTOPLASMIC



BRUCHS MEMBRANE

LOCALISED BETWEEN RPE AND
CHORIOCAPILLARIS (CC)

PROVIDES A SEMIPERMEABLE FILTRATION
BARRIER THROUGH WHICH MAJOR METABOLIT
EXCHANGE TAKE PLACE

CC --- NUTRIENT (THROUGH MB, RPE) -----
PHOTORECEPTOR PR CELLULAR BREAKDOWN
PRODUCT (RPE, MB) --CC




DRUSEN
GEOGRAPHIC
ATROPHY
NEOVASCULAR DEVELOPMENT
TREATMENT

*NO T/ FOR DRY OR EARLY AMD

*LASER PHOTOCOACULATION PDT
(PHOTODYNAMIC TH/)
TTT TRANSPUPILLAY THERMO TH/)