Bio Technology

2007-2008
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY

HYDERABAD
B.TECH. BIO-TECHNOLOGY
I YEAR COURSE STRUCTURE
________________________________________________________________________________
CODE SUBJECT T P/D C
________________________________________________________________________________
C Programming and Data Structures 3+1* - 6
English 2+1* -
!asic Electrical and Electronics Engineering 3+1* - 6
"undamentals o# !iolog$ +1* - 8
%athematics - & 3+1* - 6
Process Engineering Princi'les 3+1* - 6
Engineering Dra(ing - 3
Engineering )or*sho' Practice - 3
Com'uter Programming +a, - 3
-''lied Electrical and Electronics Engineering +a, - 3
English +anguage Communication S*ills +a, - 3
..................................................................................
Total 24 ! !"
__________________________________________________________________________________
1
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II YEAR I SE#ESTER
COURSE STRUCTURE
_________________________________________________________________________
CODE SUBJECT T P C
_________________________________________________________________________
!iochemistr$ +1* -
/hermod$namics #or !iotechnologists +1* -
Cell !iolog$ +1* -
%athematics -&& +1* -
0enetics +1* -
%icro,iolog$ +1* -
!iochemistr$ +a, - 3 2
Cell !iolog$ and %icro,iolog$ +a, - 3 2
..........................................................................
TOTAL $% " 2&
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II YEAR II SE#ESTER
COURSE STRUCTURE
_________________________________________________________________________
CODE SUBJECT T P C
_________________________________________________________________________
%ass /rans#er and Se'aration +1* -
En1ironmental Studies +1* -
&nstrumental %ethods o# -nal$sis +1* -
%olecular !iolog$ +1* -
Engineering Ph$sics +1* -
!io'rocess Engineering +1* -
!io'rocess Engineering +a, - 3 2
&nstrumental %ethods o# -nal$sis +a, - 3 2
.........................................................................
TOTAL $% " 2&
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2
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III YEAR I SE#ESTER
COURSE STRUCTURE
__________________________________________________________________________
CODE SUBJECT T P C
_________________________________________________________________________
/rans'ort Phenomena in !io Processes +1* -
!iochemical 2eaction Engineering - & +1* -
!asic &ndustrial and En1ironmental !iotechnolog$ +1* -
0enetic Engineering +1* -
Plant !iotechnolog$ +1* -
%anagerial Economics and "inancial -nal$sis +1* -
%olecular !iolog$ and 0enetic Engineering +a, - 3 2
-d1anced English Communication S*ills +a, - 3 2
..........................................................................
TOTAL $% " 2&
__________________________________________________________________________
III YEAR II SE#ESTER
COURSE STRUCTURE
__________________________________________________________________________
CODE SUBJECT T P C
___________________________________________________________________________
Com'utational %olecular !iolog$ +1* -
!iochemical 2eaction Engineering - && +1* -
3eat /rans#er in !io'rocesses +1* -
&nstrumentation and !io Process Control +1* -
&mmunolog$ +1* -
Pro,a,ilit$ and Statistics +1* -
Plant /issue Culture +a, - 3 2
&mmunolog$ +a, - 3 2
..........................................................................
TOTAL $% " 2&
__________________________________________________________________________
3
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IV YEAR I SE#ESTER
COURSE STRUCTURE
________________________________________________________________________________
CODE SUBJECT T P C
_________________________________________________________________________________
!ioin#ormatics +1* -
!io Ethics4 !io Sa#et$ -nd &ntellectual Pro'ert$ 2ights +1* -
Do(nstream Processing +1* -
!iosensors and !ioelectronics +1*
ELECTIVE 'I +1* -
!iomaterials Science and /echnolog$
Cell Signaling
Structural !iolog$
Cancer !iolog$
ELECTIVE 'II +1* -
Creati1it$ &nno1ation and Product De1elo'ment
5ano !iotechnolog$
%eta,olic Engineering
!ioin#ormatics +a, - 3 2
Do(nstream Processing +a, - 3 2
...................................................................................
TOTAL $% " 2&
___________________________________________________________________________________
IV YEAR II SE#ESTER
COURSE STRUCTURE
________________________________________________________________________________
CODE SUBJECT T P C
________________________________________________________________________________
-nimal Cell Science and /echnolog$ +1* -
ELECTIVE 'III +1* -
"ood Science and /echnolog$
%olecular %odeling and Drug Design
!io Process Economics and Plant Design
ELECTIVE 'IV +1* -
!io'harmaceutical /echnolog$
Ph$tochemicals and 3er,al %edicine
!io'rocess 6'timi7ation
&ndustr$ 6riented %ini 'ro8ect - - 2
Seminar - - 2
Pro8ect )or* - - 10
Com'rehensi1e 9i1a - - 2
.................................................................................
TOTAL ! - 2&
.................................................................................
4
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I Y(a) B . T(*+ BT T P C
$,- % "
C PROGRA##ING AND DATA STRUCTURES
UNIT - I
-lgorithm : 'seudo code4 #lo(chart4 'rogram de1elo'ment ste's4 structure o# C 'rogram4 - Sim'le C
'rogram4 identi#iers4 ,asic data t$'es and si7es4 Constants4 1aria,les4 arithmetic4 relational and logical
o'erators4 increment and decrement o'erators4 conditional o'erator4 ,it-(ise o'erators4 assignment
o'erators4 e;'ressions4 t$'e con1ersions4 conditional e;'ressions4 'recedence and order o# e1aluation<
&n'ut-out'ut statements4 statements and ,loc*s4 i# and s(itch statements4 loo's- (hile4 do-(hile and #or
statements4 ,rea*4 continue4 goto and la,els4 'rogramming e;am'les<
UNIT - II
Designing structured 'rograms4 "unctions4 ,asics4 'arameter 'assing4 storage classes- e;tern4 auto4
register4 static4 sco'e rules4 ,loc* structure4 user de#ined #unctions4 standard li,rar$ #unctions4 recursi1e
#unctions4 header #iles4 C 're'rocessor4 e;am'le c 'rograms<
UNIT - III
-rra$s- conce'ts4 declaration4 de#inition4 accessing elements4 storing elements4 arra$s and #unctions4 t(o-
dimensional and multi-dimensional arra$s4 a''lications o# arra$s< 'ointers- conce'ts4 initiali7ation o# 'ointer
1aria,les4 'ointers and #unction arguments4 address arithmetic4 Character 'ointers and #unctions4 'ointers to
'ointers4 'ointers and multidimensional arra$s4 d$namic memor$ managements #unctions4 command line
arguments4 c 'rogram e;am'les<
UNIT - IV
Deri1ed t$'es- structures- declaration4 de#inition and initiali7ation o# structures4 accessing structures4 nested
structures4 arra$s o# structures4 structures and #unctions4 'ointers to structures4 sel# re#erential structures4
unions4 t$'ede#4 ,it#ields4 C 'rogram e;am'les<
UNIT - V
&n'ut and out'ut = conce't o# a #ile4 te;t #iles and ,inar$ #iles4 streams4 standard &:o4 "ormatted &:o4 #ile &:o
o'erations4 error handling4 C 'rogram e;am'les<
UNIT - VI
Searching = +inear and ,inar$ search methods4 sorting = !u,,le sort4 selection sort4 &nsertion sort4 >uic*
sort4 merge sort<
UNIT ' VII
&ntroduction to data structures4 singl$ lin*ed lists4 dou,l$ lin*ed lists4 circular list4 re'resenting stac*s and
?ueues in C using arra$s and lin*ed lists4 in#i; to 'ost #i; con1ersion4 'ost#i; e;'ression e1aluation<
UNIT - VIII
/rees- !inar$ tress4 terminolog$4 re'resentation4 tra1ersals4 gra'hs- terminolog$4 re'resentation4 gra'h
tra1ersals @d#s A ,#sB
TE.T BOO/S 0
1< Com'uter science4 - structured 'rogramming a''roach using C4 !<-< "orou7an and 2<"< 0il,erg4
/hird edition4 /homson<
2< DataStructures Csing C = -<S</anen,aum4 D< +angsam4 and %<E< -ugenstein4 P3&:Pearson
education<
RE1ERENCES 0
1< CA Data structures = P< Padmana,ham4 !<S< Pu,lications<
2< /he C Programming +anguage4 !<)< Fernighan4 Dennis %<2itchie4
P3&:Pearson Education
3< C Programming (ith 'ro,lem sol1ing4 E<-< Eones A F< 3arro(4
dreamtech Press
< Programming in C = Ste'hen 0< Fochan4 &&& Edition4 Pearson Eductaion<
G< Data Structures and Program Design in C4 2<Fruse4 C<+< /ondo4 !P +eung4 Shashi %4 Second
Edition4 Pearson Education<
5
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I Y(a) B.T(*+ BT T P C
2,- % 4
ENGLISH
. INTRODUCTION 0
&n 1ie( o# the gro(ing im'ortance o# English as a tool #or glo,al communication and the conse?uent
em'hasis on training students to ac?uire communicati1e com'etence4 the s$lla,us has ,een designed to
de1elo' linguistic and communicati1e com'etence o# Engineering students< /he 'rescri,ed ,oo*s and the
e;ercises are meant to ser1e ,roadl$ as studentsH hand,oo*s<
&n the English classes4 the #ocus should ,e on the s*ills o# reading4 (riting4 listening and s'ea*ing and #or
this the teachers should use the te;t 'rescri,ed #or detailed stud$< "or e;am'le4 the students should ,e
encouraged to read the te;ts:selected 'aragra'hs silentl$< /he teachers can as* com'rehension
?uestions to stimulate discussion and ,ased on the discussions students can ,e made to (rite short
'aragra'hs:essa$s etc<
/he te;t #or non-detailed stud$ is #or e;tensi1e reading:reading #or 'leasure ,$ the students< 3ence4 it is
suggested that the$ read it on their o(n (ith to'ics selected #or discussion in the class< /he time should
,e utili7ed #or (or*ing out the e;ercises gi1en a#ter each section 4 as also #or su''lementing the
e;ercises (ith authentic materials o# a similar *ind #or e;am'le4 #rom ne(s'a'er articles4 ad1ertisements4
'romotional material etc<. However, the stress in this syllabus is on skill development and practice of
language skills.
2. OBJECTIVES0
a< /o im'ro1e the language 'ro#icienc$ o# the students in English (ith em'hasis on +S2) s*ills<
,< /o e?ui' the students to stud$ academic su,8ects (ith greater #acilit$ through the theoretical and
'ractical com'onents o# the English s$lla,us<
c< /o de1elo' the stud$ s*ills and communication s*ills in #ormal and in#ormal situations<
$. SYLLABUS 0
L23t(4245 S62ll30
6,8ecti1es
1< /o ena,le students to de1elo' their listening s*ill so that the$ ma$ a''reciate its role in the +S2)
s*ills a''roach to language and im'ro1e their 'ronunciation
2. /o e?ui' students (ith necessar$ training in listening so that can com'rehend the s'eech o# 'eo'le
o# di##erent ,ac*grounds and regions
Students should be given practice in listening to the sounds of the language to be able to recognise them, to
distinguish between them to mark stress and recognise and use the right intonation in sentences.
I +istening #or general content
I +istening to #ill u' in#ormation
I &ntensi1e listening
I +istening #or s'eci#ic in#ormation
S7(a6245 S62ll3 0
6,8ecti1es
1< /o ma*e students a(are o# the role o# s'ea*ing in English and its contri,ution to their success<
2< /o ena,le students to e;'ress themsel1es #luentl$ and a''ro'riatel$ in social and 'ro#essional
conte;ts<
I 6ral 'ractice
I Descri,ing o,8ects:situations:'eo'le
I 2ole 'la$ = &ndi1idual:0rou' acti1ities @Csing e;ercises #rom all the nine units o# the 'rescri,ed te;tJ
Learning English : A ommunicative Approach<B
I Eust - %inute@E-%B Sessions<
R(a8245 S62ll30
6,8ecti1es
1< /o de1elo' an a(areness in the students a,out the signi#icance o# silent reading and
com'rehension<
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2< /o de1elo' the a,ilit$ o# students to guess the meanings o# (ords #rom conte;t and gras' the
o1erall message o# the te;t4 dra( in#erences etc<
I S*imming the te;t
I Cnderstanding the gist o# an argument
I &denti#$ing the to'ic sentence
I &n#erring le;ical and conte;tual meaning
I Cnderstanding discourse #eatures
I 2ecogni7ing coherence:se?uencing o# sentences
NOTE 0 !he students will be trained in reading skills using the prescribed te"t for detailed study.
!hey will be e"amined in reading and answering #uestions using $unseen% passages which
may be taken from the non&detailed te"t or other authentic te"ts, such as
maga'ines(newspaper articles.
W)2t245 S62ll3 0
6,8ecti1es
1< /o de1elo' an a(areness in the students a,out (riting as an e;act and #ormal s*ill
2< /o e?ui' them (ith the com'onents o# di##erent #orms o# (riting4 ,eginning (ith the lo(er order ones<
I )riting sentences
I Cse o# a''ro'riate 1oca,ular$
I Paragra'h (riting
I Coherence and cohesi1eness
I 5arration : descri'tion
I 5ote %a*ing
I "ormal and in#ormal letter (riting
I Editing a 'assage
4. TE.TBOO/S PRESCRIBED0
&n order to im'ro1e the 'ro#icienc$ o# the student in the ac?uisition o# the #our s*ills mentioned a,o1e4 the
#ollo(ing te;ts and course content4 di1ided into E25+t U42t34 are 'rescri,edJ
For Detailed study
1. LEARNING ENGLISH0 A Communicative Approach4 3$dera,adJ 6rient +ongman4 2006< @Si;
Selected +essonsB
For Non-detailed study
2. WINGS O1 1IRE0 An Autobiography APJ Abdul Kalam4 -,ridged 1ersion (ith E;ercises4
Cni1ersities Press @&ndiaB P1t< +td<4 200<
-< S/CDD %-/E2&-+J
Cnit =&
1. -stronom$ #rom +E-25&50 E50+&S3J A ommunicative Approach, 6rient +ongman4 200G<
2. Cha'ters 1- 9)o: )ings o# "ire0 -n -uto,iogra'h$ ' APJ A;8<l /ala:= a4 a;)285(8 >()32o4
?2t+ E@()*23(3= U42>()32t2(3 P)(33 AI482aB P>t. Lt8.=2%%4
Cnit =&&
3. &n#ormation /echnolog$ 9)o: +E-25&50 E50+&S3J A ommunicative Approach, O)2(4t
Lo45:a4= 2%%!.
4. Cha'ters G-8 9)o: )ings o# "ire0 -n -uto,iogra'h$ ' APJ A;8<l /ala:= a4 a;)285(8 >()32o4
?2t+ E@()*23(3= U42>()32t2(3 P)(33 AI482aB P>t. Lt8.=2%%4
Cnit =&&&
5. 3umour 9)o: +E-25&50 E50+&S3J A ommunicative Approach, O)2(4t Lo45:a4= 2%%!.
6. Cha'ters K-12 9)o: )ings o# "ire0 -n -uto,iogra'h$ ' APJ A;8<l /ala:= a4 a;)285(8 >()32o4
?2t+ E@()*23(3.= U42>()32t2(3 P)(33 AI482aB P>t. Lt8.=2%%4
Cnit =&9
7. En1ironment 9)o: +E-25&50 E50+&S3J A ommunicative Approach, O)2(4t Lo45:a4= 2%%!.
7
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8. Cha'ters 13-16 9)o: )ings o# "ire0 -n -uto,iogra'h$ ' APJ A;8<l /ala:= a4 a;)285(8 >()32o4
?2t+ E@()*23(3= U42>()32t2(3 P)(33 AI482aB P>t. Lt8.=2%%4
Cnit =9
9. &ns'iration 9)o: +E-25&50 E50+&S3J A ommunicative Approach, O)2(4t Lo45:a4= 2%%!.
10.Cha'ters 17-20 9)o: )ings o# "ire0 -n -uto,iogra'h$ ' APJ A;8<l /ala:= a4 a;)285(8 >()32o4
?2t+ E@()*23(3= U42>()32t2(3 P)(33 AI482aB P>t. Lt8.=2%%4.
Cnit = 9&
11.3uman &nterest 9)o: +E-25&50 E50+&S3J A ommunicative Approach, O)2(4t Lo45:a4=
2%%!.
12.Cha'ters 21-2 9)o: )ings o# "ire0 -n -uto,iogra'h$ ' APJ A;8<l /ala:= a4 a;)285(8 >()32o4
?2t+ E@()*23(3= U42>()32t2(3 P)(33 AI482aB P>t. Lt8.= 2%%4.
* E;ercises #rom the lessons not 'rescri,ed shall also ,e used #or classroom tas*s<
U42t ' VII
E@()*23(3 o4
2eading and )riting S*ills
2eading Com'rehension
Situational dialogues
+etter (riting
Essa$ (riting
U42t ' VIII
P)a*t2*( E@()*23(3 o4 R(:(82al G)a::a) *o>()245
Common errors in English4 Su,8ect-9er, agreement4 Cse o# -rticles and Pre'ositions4
/ense and as'ect
Vo*a;<la)C 8(>(lo7:(4t *o>()245
S$non$ms A -nton$ms4 one-(ord su,stitutes4 're#i;es A su##i;es4 &dioms A 'hrases4 (ords
o#ten con#used<
RE1ERENCES 0
1. St)(45t+(4 Yo<) E45l23+= !has*aran A 3ors,urgh4 6;#ord Cni1ersit$ Press
2. Ba32* Co::<42*at2o4 S62ll3 9o) T(*+4olo5C4 -ndrea E 2uther#oord4 Pearson Education -sia<
3. #<)7+CD3 E45l23+ G)a::a) ?2t+ CD= %ur'h$4 Cam,ridge Cni1ersit$ Press
4. E45l23+ S62ll3 9o) T(*+42*al St<8(4t3 ,$ 6rient +ongman
5. E>()C8aC D2alo5<(3 24 E45l23+ ,$ 2o,ert E< Di;son4 Prentice-3all o# &ndia +td<4 2006<
6. E45l23+ 1o) T(*+42*al Co::<42*at2o44 9ol< 1 A 24 ,$ F< 2< +a*shmi 5ara$anan4 Sci tech<
Pu,lications<
7. A Ha48 ;oo6 o9 E45l23+ 9o) E4524(()3 E T(*+4olo523t3 ,$ Dr< P< Eliah4 !< S<
Pu,lications<
8. D(>(lo7245 Co::<42*at2o4 S62ll3 ,$ Frishna %ohan A %eera !ener8i @%acmillanB
9. S7(a6245 a48 W)2t245 9o) E99(*t2>( B<324(33 Co::<42*at2o4= "rancis Soundarara84 %ac%illan
&ndia +td<4 2007<
10. T+( O@9o)8 G<28( to W)2t245 a48 S7(a6245= Eohn Seel$4 6;#ord
8
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BASIC ELECTRICAL AND ELECTRONICS ENGINEERING
UNIT I ELECTRICAL CIRCUITS
6hms +a( -Fircho##s +a(s - stead$ state solution o# D C Circuits - &ntroduction to -C circuits - )a1e#orms
and 2%S 1alue - 'o(er and 'o(er #actor4 single 'hase and three 'hase ,alanced circuits<
UNIT II ELECTRICAL #ACHINES
Princi'les o# o'eration and characteristics o# D C machines4 /rans#ormers @single 'hase and three 'haseB -
S$nchronous %achines - three Phase and single 'hase induction motors - @o'< Princi'lesB<
UNIT III #EASURE#ENTS
%o1ing coil and mo1ing iron instruments @-mmeter and 1oltmeterB< D$namometer t$'e (att meters and
energ$ meters @o'< Princi'lesB<
UNIT IV
SE#ICONDUCTOR DEVICES E RECTI1IERS
Classi#ication o# solids ,ased on energ$ hand theor$ - &ntrinsic semiconductors - E;trinsic semiconductors -
P t$'e and 5 t$'e - P-5 8unction - 9 & characteristic o# P5 8unction diode - Lener diode - Lener diode
characteristics - 3al# (a1e and #ull (a1e recti#iers - 9oltage regulation4 SC24 Diac4 /riac4 Characteristics and
sim'le a''lications<
UNIT V TRANSISTORS
!i'olar 8unction transistor - C!4 CE4 CC - Con#igurations and characteristics = !iasing circuits - "ield E##ect
/ransistor - Con#igurations and characteristics - "E/ am'li#ier - CE/ - characteristics and sim'le a''lications
- s(itching transistors - conce't o# #eed ,ac* - negati1e #eed ,ac* - a''lication in tem'erature and motor
s'eed control<
UNIT VI A#PLI1IERS
Elementar$ treatment o# 1oltage am'li#ier - Class -4 ! and C 'o(er am'li#iers - 'rinci'les o# /uned
am'li#iers<
UNIT VII SIGNAL GENERATORS AND LINEAR ICDS
Sinusoidal oscillators - 'ositi1e #eed ,ac* - 2C 'hase shi#t4 3artle$4 Col'itHs4 )ien ,ridge 6scillators -
multi1i,rators - o'erational am'li#ier - adder4 multi'lier4 integrator and di##erentiators -&ntegrated circuits<
UNIT VIII DIGITAL ELECTRONICS
!inar$ num,er s$stem - -5D4 624 56/4 5-5D4 562 circuits - !oolean alge,ra - E;clusi1e 62 gate - 3al#
and "ull adders - #li' #lo's - registers and counters - -:D4 D:- con1ersion - Digital com'uter 'rinci'le<
TE.T BOO/S0
1< %ittle4 9<5<4 !asic Electrical Engineering4 /%3 Edition4 5e( - Delhi4 1KK0 2< Del /aro4 Electrical
Engineering "undamentals4 Prentice 3all o# &ndia P1t< +td<4 5e( Delhi4 Second edition<
RE1ERENCES
1< %illman A 3al*ias4 &ntegrated Electronics4 %c0ra( 3ill4 1K7K<
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1UNDA#ENTALS O1 BIOLOGY
UNIT I0 INTRODUCTION TO #ICROORGANIS#S
Di1ersit$ in ,iological s$stems4 Cell ,iolog$ and cell structure4 Di##erence ,et(een Pro*ar$otes A
Eu*ar$otes< Fingdom s$stems< "i1e-*ingdom classi#ication 0eneral characters4 !rie# account on Ecolog$4
%or'holog$4 5utrition4 +ocomotion and 2e'roduction4 use#ul and harm#ul e##ects o# !acteria4 9iruses4 -lgae4
"ungi and Proto7oans<
UNIT II0 PLANT BIOLOGY
Classi#ication o# Plant Fingdom< Conce'ts o# 0ro(th4 %eristems< De1elo'ment o# di##erent 'lant organsM
Plant gro(th regulatorsM Economic &m'ortance o# Plants4 !iolog$ o# Pests in relation to 2ice4 Cotton4
Sugarcane and 0roundnut<
UNIT III0 ANI#AL BIOLOGY
Classi#ication o# -nimal Fingdom4 "unctions4 mor'holog$4 gro(th and 2e'roduction4 economic im'ortance<
Ph$logen$ o# &n1erte,rate A 9erte,rate Ph$la4 Conce'ts
o# S'ecies A Ecos$stem< Proto7oan Parasites = t(o im'ortant #orms in man @ )lasmodium, Entamoeba
histolyticaB4 3elminthes @ *asciotopsis buski, !aenia solium, Ascaris, +ucharia bancraftiB
UNIT IV0 BASIC #OLECULAR BIOLOGY
0eneticsJ D5- as genetic material4 Structure o# D5-4 D5- re'lication4 /ranscri'tion4 /ranslation4 0enes to
'roteins to 'rotein #unction4 0ene e;'ression and regulation4 2ecom,inant D5- technolog$<
UNIT V0 HU#AN BIOLOGY I
&ntroduction o# ,od$ as a (hole4 Cells and /issue 6rgani7ation4 Electrol$tes and !od$ #luids< Ph$siolog$ o#
!lood< Digesti1e s$stem4 2es'irator$ s$stem and Endocrine s$stem<
UNIT VI0 HU#AN BIOLOGY II
3uman Ph$siolog$J !iological a;ons and neurons4 5euromuscular and s$na'tic 8unctions4 Sensor$ s$stems
- hearing4 taste4 smell and 1isual rece'tors<
UNIT VII0 PHOTOSYNTHESIS
!acterial A Plant 'hotos$nthesisM o;$genic and ano;$genic 'hotos$nthesisM chloro'h$ll as tra''er o# solar
energ$4 'hotos$nthetic reaction centres4 3ill reaction4 PS & A PS &&4 Photo'hos'hor$lation - c$clic A non-
c$clicM Dar* reaction A C62 #i;ation<
UNIT VIII 0 APPLICATIONS O1 BIOTECHNOLOGY0 BASIC CONCEPTS
Drugs and Chemicals #rom Plants A -nimals4 De#inition and im'ortance @in generalB o# !io#uels4 io#ertili7ers4
!io'esticides4 !ioindicators and !iosensors4 %icro,ial En7$mes4 Single Cell Protein @SCPB4 %onoclonal
-nti,odies4 &ntroduction to /ransgenic Plants A -nimals<
TE.T BOO/S0
1< 3<0< 2ehen and 0<2eed4 ,iotechnolog$ 9olume & A 2
2< !asic !iotechnolog$4 Second Edition4 ,$ Colin 2atledge and !8orm
Fristiansen4 Cam,ridge Cni1ersit$ Press<
3< -natom$ and Ph$siolog$ &n 3ealth and Disease4F< E<)< )ilison and
-< )augh4 Churchill A +i1ingston<
RE1ERENCES
1B Plant Ph$siolog$ "<! Salis,ur$ A C<)< 2oss th edition /homson )ads(orth
2B Dr< C<C< Chatter8ee, Human )hysiology ,--th Edition. /ol 0 and 00, %edical
-llied -genc$4 Fol*ata4 1K87<
10
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JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSIT
HYDERABAD
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#ATHE#ATICS ' I
UNIT ' I
Di##erential e?uations o# #irst order and #irst degree = e;act4 linear and !ernoulli< -''lications to 5e(tonHs
+a( o# cooling4 +a( o# natural gro(th and deca$4 orthogonal tra8ectories<
UNIT ' II
5on-homogeneous linear di##erential e?uations o# second and higher order (ith constant coe##icients (ith
23S term o# the t$'e e
ax
4 Sin a;4 cos a;4 'ol$nomials in ;4 e
ax
9@;B4 ;9@;B4 method o# 1ariation o#
'arameters<
UNIT ' III
2olleHs /heorem = +agrangeHs %ean 9alue /heorem = Cauch$Hs mean 1alue /heorem = 0enerali7ed %ean
9alue theorem @all theorems (ithout 'roo#B "unctions o# se1eral 1aria,les = "unctional de'endence-
Eaco,ian- %a;ima and %inima o# #unctions o# t(o 1aria,les (ith constraints and (ithout constraints
UNIT ' IV
2adius4 Centre and Circle o# Cur1ature = E1olutes and En1elo'es Cur1e tracing = Cartesian 4 'olar and
Parametric cur1es<
UNIT ' V
-''lications o# integration to lengths4 1olumes and sur#ace areas in Cartesian and 'olar coordinates multi'le
integrals - dou,le and tri'le integrals = change o# 1aria,les = change o# order o# integration<
UNIT ' VI
Se?uences = series = Con1ergences and di1ergence = 2atio test = Com'arison test = &ntegral test =
Cauch$Hs root test = 2aa,eHs test = -,solute and conditional con1ergence
UNIT ' VII
9ector CalculusJ 0radient- Di1ergence- Curl and their related 'ro'erties o# sums- 'roducts- +a'lacian and
second order o'erators< 9ector &ntegration - +ine integral = (or* done = Potential #unction = area- sur#ace
and 1olume integrals 9ector integral theoremsJ 0reenHs theorem-Sto*eHs and 0aussHs Di1ergence /heorem
@)ith out 'roo#B< 9eri#ication o# 0reenHs - Sto*eHs and 0aussHs /heorems<
UNIT ' VIII
+a'lace trans#orm o# standard #unctions = &n1erse trans#orm = #irst shi#ting /heorem4 /rans#orms o#
deri1ati1es and integrals = Cnit ste' #unction = second shi#ting theorem = DiracHs delta #unction =
Con1olution theorem = Periodic #unction - Di##erentiation and integration o# trans#orms--''lication o# +a'lace
trans#orms to ordinar$ di##erential e?uations Partial #ractions-3ea1isideHs Partial #raction e;'ansion theorem<
T(@t Boo630
1< - te;t !oo* o# Engineering %athematics4 9ol-1 /< F< 9< &$engar4 !< Frishna 0andhi and 6thers4 S<
Chand A Com'an$<
2< - te;t !oo* o# Engineering %athematics4 C< San*araiah4 9< 0< S< !oo* +in*s<
3< - te;t !oo* o# Engineering %athematics4 Shahna7 !athul4 2ight Pu,lishers<
< - te;t !oo* o# Engineering %athematics4 P< 5agesh(ara 2ao4 D< 5arasimhulu A 5< Pra,ha*ar 2ao4
Dee'thi Pu,lications<
R(9()(4*(30
1< - te;t !oo* o# Engineering %athematics4 !< 9< 2aman4 /ata %c 0ra( 3ill<
2< -d1anced Engineering %athematics4 &r1in Fre$s7ig4 )ile$ &ndia P1t< +td<
3< - te;t !oo* o# Engineering %athematics4 /hamson !oo* Collection<
11
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$,- % "
PROCESS ENGINEERING PRINCIPLES
UNIT-I
-''lication o# Engineering 'rinci'les in ,iotech &ndustries-&ntroduction to unit o'erations and unit
'rocesses=a''lication o# trans'ort 'henomenon 'rinci'les @momentum4 mass and heat trans#erB in
,io'rocessing<
UNIT-II
Cnits and dimensions4 ,asic ?uantities and deri1ed units< Con1ersion o# units< Conce't o# mass and #orce4
de#inition o# gc and its utilit$< 9arious e?uations o# state including ideal gas la( to e1aluate P-9</ data4 their
a''lication in 'rocess calculations ,$ sol1ing ,asics numerical 'ro,lems<
UNIT-III
"luid mechanics- Pro'erties o# #luids4 #luid statics4 energ$ ,alance in #luid #lo( through 'i'es and condunits4
!ernoulliHs e?uation and its a''lication4 calculation o# 'o(er re?uired #or 'um'ing #luids< E;am'les #rom
,io'rocessing s$stems <
UNIT-IV
2heolog$ o# #luids - 5e(tonHs la( o# 1iscosit$< Conce't o# 5e(tonian and non - 5e(tonian #luids- Di##erent
t$'es o# non-5e(tonian #luids (ith e;am'les in ,io'rocessing< %easurement o# 1iscosit$ using e;trusion
rheometer4 'late and cone 1iscometer4 coa;ial c$linder 1iscometer<
UNIT-V
"lo( through 'i'es4 a1erage 1elocit$4 #lo( regimes4 ,oundar$ la$er conce't< +aminar and tur,ulent #lo( =
characteri7ation ,$ 2e$noldHs num,er4 'ressure dro' due to
s*in #riction and #orm #riction4 #riction #actor chart4 3agen -Poiseuille e?uation< !rie# introduction to #lo( o#
com'ressi,le #luids<
UNIT-VI
"lo( 'ast immersed ,odiesJ De#inition o# drag and drag coe##icient< "riction in #lo( through ,eds o# solids4
deri1ation o# #riction #actor e?uations and 'ressure dro' e;'ressions< &ntroduction o# the conce't o# 'ac*ed
,eds< %otion o# 'articles through #luids4 terminal 1elocit$<
UNIT-VII
"lo( measuring and monitoring s$stems- 1al1es4 ,ends4 el,o(s4 're1ention o# lea*s4 mechanical seals4
stu##ing ,o;< "lo( measuring de1ices-manometers4 ori#ice meter4 1enture meter and rotameter<
UNIT-VIII
"luid trans'ortation machiner$J Di##erent t$'es o# 'um's4 'ositi1e dis'lacement 'um's4 reci'rocating
'um's4 dia'hragm 'um's4 'eristaltic 'um's< Calculation o# 'um' horse 'o(er<
TE.T BOO/S0
1< &ntroduction to !iochemical Engineering4 D<0<2ao4 /ata %c 3ill @200GB
2< !io-'rocess Engineering Princi'les4 Pauline %<Doran< -cademic 'ress @1KKGB
3< Cnit o'erations o# chemical engineering4%c Ca,e4 )<+4 Smith E<C<4 and 3arriot P<4 %c-0ra( 3ill4 3rd Ed<
@1KK3B<
RE1ERENCES0
1< N/echnical as'ects o# the rheological 'ro'erties o# micro,ial culturesN4 - Charles4
% @1K78B in -d1anmces in !iochemical Engineering4 0hose4 /<F<4 "iechter4 -
and !la*e,rough4 5<@EdsB4 S'inger-9erlag4 !erlin4 ''< 1-62
2< Cnit o'eration in "ood 'rocessing4 Earle4 2<+< @1KK6B Pergamon Press4 6;#ord4 PP< 212-282<
12
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% $ 4
ENGINEERING DRAWING
UNIT ' I
&ntroduction to engineering gra'hics = construction o# elli'se4 'ara,ola and h$'er,ola = c$lindrical cur1es<
UNIT ' II
6rthogra'hic 'ro8ections o# 'oints4 lines and 'lanes = a;is inclined to one 'lanes and inclined to ,oth the
'lanes<
UNIT ' III
O)t+o5)a7+2* 7)oF(*t2o43 o9 3ol283 0
C$linder4 cone4 'rism4 '$ramid and s'here 'ositions and a;is inclined to ,oth the 'lanes<
UNIT ' IV
&someric 'ro8ections o# lines4 'lanes and sim'le solids
UNIT ' V
Con1ersion o# orthogra'hic 1ie(s into isometric 1ie(s and 1ice-1ersa<
TE.T BOO/S 0
1< Engineering dra(ings !$ 5<D<!hatt
2 Engineering gra'hics !$ F<+< 5ara$ana A P<Fanna$$a
2E"E2E5CESJ-
1< Engineering dra(ing and gra'hicsJ 9enugo'al: 5e( age
2< Engineering dra(ing J Eohle : /%3
13
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% $ 4
ENGINEERING WOR/ SHOP PRACTICE
. TRADES 1OR E.ERCISES0
1< Car'entr$
2< "itting
3< /in-Smith$ and De1elo'ment o# 8o,s carried out and soldering<
< !lac* Smith$
G< 3ouse-(iring
6< "oundr$
7< &/ )or*sho'-& J Com'uter hard (are 4 identi#ication o# 'arts 4 Disassem,l$4 -ssem,l$ o# com'uter to
(or*ing condition4 Sim'le diagnostic e;ercises<
8< &/ (or*sho'-&& J &nstallation o# 6'erating s$stem (indo(s and +inu; 4 sim'le diagnostic e;ercises<
II TRADES 1OR DE#ONSTRATION E E.POSURE0
1< Plum,ing
2< )elding
3< %achine Sho'
< Po(er tools in construction4 )ood (or*ing4 Electrical Engg A %echanical Engg
G< %etal Cutting @(ater 'lasmaB
T(@t Boo630 )or* sho' %anual : P<Fannaiah: F<+<5ara$ana: Scitech 'u,lishers
14
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% $ 4
CO#PUTER PROGRA##ING LAB
6,8ecti1esJ
/o ma*e the student learn a 'rogramming language<
/o teach the student to (rite 'rograms in C sol1e the 'ro,lems
/o &ntroduce the student to sim'le linear and non linear data structures such as lists4 stac*s4
?ueues4 trees and gra'hs<
R(*o::(48(8 SC3t(:3/So9t?a)( R(G<2)(:(4t30
&ntel ,ased des*to' PC
-5S& C Com'iler (ith Su''orting Editors
W((6 l<
aB )rite a C 'rogram to #ind the sum o# indi1idual digits o# a 'ositi1e integer<
;B - "i,onacci Se?uence is de#ined as #ollo(sJ the #irst and second terms in the se?uence are 0 and 1<
Su,se?uent terms are #ound ,$ adding the 'receding t(o terms in the se?uence< )rite a C 'rogram to
generate the #irst n terms o# the se?uence<
*B )rite a C 'rogram to generate all the 'rime num,ers ,et(een 1 and n4 (here n is a 1alue su''lied ,$ the
user<
W((6 2<
aB )rite a C 'rogram to calculate the #ollo(ing SumJ
SumO1-;
2
:2P +;
:P-;
6
:6P+;
8
:8P-;
10
:10P
;B )rite a C 'rogram toe #ind the roots o# a ?uadratic e?uation<
W((6 $
aB )rite C 'rograms that use ,oth recursi1e and non-recursi1e #unctions
iB /o #ind the #actorial o# a gi1en integer<
iiB /o #ind the 0CD @greatest common di1isorB o# t(o gi1en integers<
iiiB /o sol1e /o(ers o# 3anoi 'ro,lem<
W((6 4
aB /he total distance tra1elled ,$ 1ehicle in QtH seconds is gi1en ,$ distance O ut+1:2at
2
(here QuH and QaH
are the initial 1elocit$ @m:sec<B and acceleration @m:sec
2
B< )rite C 'rogram to #ind the distance tra1elled at
regular inter1als o# time gi1en the 1alues o# QuH and QaH< /he 'rogram should 'ro1ide the #le;i,ilit$ to the user
to select his o(n time inter1als and re'eat the calculations #or di##erent 1alues o# QuH and QaH<
;B )rite a C 'rogram4 (hich ta*es t(o integer o'erands and one o'erator #orm the user4 'er#orms the
o'eration and then 'rints the result< @Consider the o'erators +4-4*4 :4 R and use S(itch StatementB
W((6 !
aB )rite a C 'rogram to #ind ,oth the larges and smallest num,er in a list o# integers<
;B )rite a C 'rogram that uses #unctions to 'er#orm the #ollo(ingJ
iB -ddition o# /(o %atrices
iiB %ulti'lication o# /(o %atrices
W((6 "
aB )rite a C 'rogram that uses #unctions to 'er#orm the #ollo(ing o'erationsJ
iB /o insert a su,-string in to gi1en main string #rom a gi1en 'osition<
iiB /o delete n Characters #rom a gi1en 'osition in a gi1en string<
;B )rite a C 'rogram to determine i# the gi1en string is a 'alindrome or not
W((6 H
aB )rite a C 'rogram that dis'la$s the 'osition or inde; in the string S (here the string / ,egins4 or = 1 i# S
doesnHt contain /<
;B )rite a C 'rogram to count the lines4 (ords and characters in a gi1en te;t<
15
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W((6 &
aB )rite a C 'rogram to generate PascalHs triangle<
;B )rite a C 'rogram to construct a '$ramid o# num,ers<
W((6 I
)rite a C 'rogram to read in t(o num,ers4 ; and n4 and then com'ute the sum o# this geometric
'rogressionJ
1+;+;
2
+;
3
+SSSS<+;
n
"or e;am'leJ i# n is 3 and ; is G4 then the 'rogram com'utes 1+G+2G+12G<
Print ;4 n4 the sum
Per#orm error chec*ing< "or e;am'le4 the #ormula does not ma*e sense #or negati1e e;'onents = i# n is less
than 0< 3a1e $our 'rogram 'rint an error message i# nT04 then go ,ac* and read in the ne;t 'air o# num,ers
o# (ithout com'uting the sum< -re an$ 1alues o# ; also illegal U &# so4 test #or them too<
W((6 %
aB 2Hs com'lement o# a num,er is o,tained ,$ scanning it #rom right to le#t and com'lementing all the ,its
a#ter the #irst a''earance o# a 1< /hus 2Hs com'lement o# 11100 is 00100< )rite a C 'rogram to #ind the 2Hs
com'lement o# a ,inar$ num,er<
;B )rite a C 'rogram to con1ert a 2oman numeral to its decimal e?ui1alent<
W((6
)rite a C 'rogram that uses #unctions to 'er#orm the #ollo(ing o'erationsJ
iB 2eading a com'le; num,er
iiB )riting a com'le; num,er
iiiB -ddition o# t(o com'le; num,ers
i1B %ulti'lication o# t(o com'le; num,ers
@5oteJ re'resent com'le; num,er using a structure<B
W((6 2
aB )rite a C 'rogram (hich co'ies one #ile to another<
;B )rite a C 'rogram to re1erse the #irst n characters in a #ile<
@5oteJ /he #ile name and n are s'eci#ied on the command line<B
W((6 $
)rite a C 'rogram that uses #unctions to 'er#orm the #ollo(ing o'erations on singl$ lin*ed list<J
iB Creation iiB &nsertion iiiB Deletion i1B /ra1ersal
W((6 4
)rite a C 'rogram that uses #unctions to 'er#orm the #ollo(ing o'erations on dou,l$ lin*ed list<J
iB Creation iiB &nsertion iiiB Deletion i1B /ra1ersal in ,oth (a$s
W((6 !
)rite C 'rograms that im'lement stac* @its o'erationsB using
iB -rra$s iiB Pointers
W((6 "
)rite C 'rograms that im'lement >ueue @its o'erationsB using
iB -rra$s iiB Pointers
W((6 H
)rite a C 'rogram that uses Stac* o'erations to 'er#orm the #ollo(ingJ
iB Con1erting in#i; e;'ression into 'ost#i; e;'ression
iiB E1aluating the 'ost#i; e;'ression
W((6 &
)rite a C 'rogram that uses #unctions to 'er#orm the #ollo(ingJ
iB Creating a !inar$ /ree o# integers
iiB /ra1ersing the a,o1e ,inar$ tree in 'reorder4 inorder and 'ostorder<
16
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W((6 I
)rite C 'rograms that use ,oth recursi1e and non recursi1e #unctions to 'er#orm the #ollo(ing searching
o'erations #or a Fe$ 1alue in a gi1en list o# integers J
iB +inear search iiB !inar$ search
W((6 2%
)rite C 'rograms that im'lement the #ollo(ing sorting methods to sort a gi1en list o# integers in ascending
orderJ
iB !u,,le sort iiB >uic* sort
W((6 2
)rite C 'rograms that im'lement the #ollo(ing sorting methods to sort a gi1en list o# integers in ascending
orderJ
iB &nsertion sort iiB %erge sort
W((6 22
)rite C 'rograms to im'lement the +agrange inter'olation and 5e(ton- 0regor$ #or(ard inter'olation<
W((6 2$
)rite C 'rograms to im'lement the linear regression and 'ol$nomial regression algorithms<
W((6 24
)rite C 'rograms to im'lement /ra'e7oidal and Sim'son methods<
T(@t Boo63
1< C 'rogramming and Data Structures4 P< Padmana,ham4 /hird Edition4 !S Pu,lications
2< Data StructuresJ - 'seudo code a''roach (ith C4 second edition 2<"< 0il,erg and !<-< "orou7an
3< Programming in C4 P<De$ A %< 0hosh4 6;#ord Cni1<Press<
< C and Data Structures4 E !alagurus(am$4 /%3 'u,lications<
17
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% $ 4
BASIC ELECTRICAL AND ELECTRONICS ENGINEERING LAB
1B Po(er measurement in 3 'hase s$stems using t(o-(attmeter method
@star connectedB
2B 9eri#ication o# *ircho##Hs la(s
3B %easurement o# cho*e coil 'arameters using 3 1oltmeter A 3 ammeter method<
B %agneti7ation characteristics o# a dc shunt machine4 determination o# critical
#ield resistance and critical s'eed<
GB 6'en circuit and Shortest Circuit on an$ 1 'hase trans#ormer<
6B +oad test on 1-'hase trans#ormer<
7B 2egulation o# 3 'hase s$nchronous generator using 6C and SC test<
8B !ra*e test on 3 'hase s?uirrel cage induction motor<
KB Cali,ration and testing o# single 'hase energ$ meter<
10B Cali,ration o# d$namometer t$'e 'o(er #actor meter<
11B Cali,ration o# P%%C ammeter and 1oltmeter crom'ton DC 'otentio meter<
12B P5 8unction diode characteristics
aB #or(ard ,ias ,B re1erse ,ias
13B Lener diode characteristics
1B /ransistor CE characteristics @&n'ut and 6ut'utB
1GB 2ecti#ier (ithout #ilters @"ull (a1e A 3al# (a1eB
16B CE/ characteristics
17B "E/ characteristics
18B Stud$ o# C26
1KB CE am'li#ier
20B Class - -m'li#ier
21B 2C Phase shi#t 6scillator
22B Stud$ o# logic gates using &CS<
18
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I Y(a) B.T(*+ BT T P C
% $ 4
ENGLISH LANGUAGE CO##UNICATION S/ILLS LAB
/he La45<a5( La; #ocuses on the 'roduction and 'ractice o# sounds o# language and #amiliarises the
students (ith the use o# English in e1er$da$ situations and conte;ts<
O;F(*t2>(30
. To (@7o3( t+( 3t<8(4t3 to a >a)2(tC o9 3(l9-243t)<*t2o4al= l(a)4()-9)2(48lC :o8(3 o9 la45<a5(
l(a)4245.
2. To +(l7 t+( 3t<8(4t3 *<lt2>at( t+( +a;2t o9 )(a8245 7a33a5(3 9)o: t+( *o:7<t() :o42to)=
t+<3 7)o>28245 t+(: ?2t+ t+( )(G<2)(8 9a*2l2tC to 9a*( *o:7<t()-;a3(8 *o:7(t2t2>( (@a:3
3<*+ GRE= TOE1L= G#AT (t*.
$. To (4a;l( t+(: to l(a)4 ;(tt() 7)o4<4*2at2o4 t+)o<5+ 3t)(33 o4 ?o)8 a**(4t= 24to4at2o4= a48
)+Ct+:.
4. To t)a24 t+(: to <3( la45<a5( (99(*t2>(lC to 9a*( 24t()>2(?3= 5)o<7 823*<332o43= 7<;l2*
37(a6245.
!. To 242t2at( t+(: 24to 5)(at() <3( o9 t+( *o:7<t() 24 )(3<:( 7)(7a)at2o4= )(7o)t ?)2t245=
9o):at-:a6245 (t*.
SYLLABUS 0
/he #ollo(ing course content is 'rescri,ed #or the E45l23+ La45<a5( La;o)ato)C sessionsJ
1< &ntroduction to the Sounds o# English- 9o(els4 Di'hthongs A Consonants<
2< &ntroduction to Stress and &ntonation<
3< Situational Dialogues : 2ole Pla$<
< 6ral Presentations- Pre'ared and E;tem'ore<
G< QEust - %inuteH Sessions @E-%B<
6< Descri,ing 6,8ects : Situations : Peo'le<
7< &n#ormation /rans#er
8< De,ate
K< /ele'honing S*ills<
10< 0i1ing Directions<
#242:<: R(G<2)(:(4t0
T+( E45l23+ La45<a5( La; 3+all +a>( t?o 7a)t30
i) T+( Co:7<t() a28(8 La45<a5( La; #or 60 students (ith 60 s$stems4 one master console4
+-5 #acilit$ and English language so#t(are #or sel#- stud$ ,$ learners<
ii) T+( Co::<42*at2o4 S62ll3 La; (ith mo1a,le chairs and audio-1isual aids (ith a P<- S$stem4
a /< 9<4 a digital stereo =audio A 1ideo s$stem and camcorder etc<
SC3t(: R(G<2)(:(4t A Ha)8?a)( *o:7o4(4tB0
omputer network with Lan with minimum 12 multimedia systems with the following specifications:
iB P = &9 Processor
aB S'eed = 2<8 03L
,B 2-% = G12 %! %inimum
cB 3ard Dis* = 80 0!
iiB 3ead'hones o# 3igh ?ualit$
S<55(3t(8 So9t?a)(0
I Cam,ridge -d1anced +earnersH English Dictionar$ (ith CD<
I /he 2osetta Stone English +i,rar$
I Clarit$ Pronunciation Po(er = Part &
I %astering English in 9oca,ular$4 0rammar4 S'ellings4 Com'osition
I Dorling Findersle$ series o# 0rammar4 Punctuation4 Com'osition etc<
I +anguage in Cse4 "oundation !oo*s P1t +td (ith CD<
6;#ord -d1anced +earnerHs Com'ass4 7
th
Edition
I +earning to S'ea* English - CDs
I %icroso#t Encarta (ith CD
I %ur'h$Hs English 0rammar4 Cam,ridge (ith CD
English in %ind4 3er,ert Puchta and Ee## Stran*s (ith %eredith +e1$4 Cam,ridge
Boo63 S<55(3t(8 9o) E45l23+ La45<a5( La; L2;)a)C Ato ;( lo*at(8 ?2t+24 t+( la; 24 a882t2o4 to t+(
CD3 o9 t+( t(@t ;oo6 ?+2*+ a)( loa8(8 o4 t+( 3C3t(:3B0
1. S7o6(4 E45l23+ @C&E"+B in 3 1olumes (ith 6 cassettes4 6CP<
19
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2. E45l23+ P)o4o<4*245 D2*t2o4a)C Daniel Eones Current Edition (ith CD<
3. S7o6(4 E45l23+- 2< F< !ansal and E< !< 3arrison4 6rient +ongman 2006 Edn<
4. E45l23+ La45<a5( Co::<42*at2o4 0 A R(a8() *<: La; #a4<al Dr - 2ama*rishna 2ao4 Dr 0
5atanam A Pro# S- San*aranara$anan4 -nuradha Pu,lications4 Chennai
5. S7(a6245 E45l23+ E99(*t2>(lC ,$ Frishna %ohan A 5P Singh @%acmillanB
6. A P)a*t2*al Co<)3( 24 E45l23+ P)o4<4*2at2o44 @(ith t(o -udio cassettesB ,$ E< Sethi4 Famlesh
Sadanand A D<9< Eindal4 Prentice-3all o# &ndia P1t< +td<4 5e( Delhi<
7. A t(@t ;oo6 o9 E45l23+ P+o4(t2*3 9o) I482a4 St<8(4t3 ,$ /<!alasu,ramanian @%acmillanB
8. E45l23+ S62ll3 9o) T(*+42*al St<8(4t3= )!SC/E (ith !ritish Council4 6+
DISTRIBUTION AND WEIGHTAGE O1 #AR/S
English anguage aboratory Practical Paper!
1< /he 'ractical e;aminations #or the English +anguage +a,orator$ shall ,e conducted as 'er the Cni1ersit$
norms 'rescri,ed #or the core engineering 'ractical sessions<
2< "or the +anguage la, sessions4 there shall ,e a continuous e1aluation during the $ear #or 2G sessional
mar*s and G0 $ear-end E;amination mar*s< 6# the 2G mar*s4 1G mar*s shall ,e a(arded #or da$-to-da$
(or* and 10 mar*s to ,e a(arded ,$ conducting &nternal +a, /est@sB< /he $ear- end E;amination shall ,e
conducted ,$ the teacher concerned (ith the hel' o# another mem,er o# the sta## o# the same de'artment
o# the same institution<
20
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II Y(a) B.T(*+ BT I-S(: T P C
4,- % 4
BIOCHE#ISTRY
UNIT I0 CARBOHYDRATE STRUCTURE E 1UNCTION
Structure and 'ro'erties o# %ono4 Di4 6ligo A 'ol$saccharides4 com'le; car,oh$drates4 Con#irmation o#
'$ranose A #uranose ring4 gl$cosidic ,ond4 0l$cogen4 starch A de;tranM as mo,ili7a,le stores o# glucose<
cellulose4 gl$co'roteins4 gl$cosaminogl$cans A lectinsM
structure and #unction<
UNIT IIJ BASIC CONCEPTS O1 ENJY#ES
&ntroduction to En7$mes4 5omenclature4 "unctions4 %echanism o# action and control 4 %ichaelis = %enten
En7$mes and -llosteric En7$mes
UNIT III CARBOHYDRATE #ETABOLIS#
0l$col$sis4 0lucogenesis4 0l$cogenol$sis4 0luconeogenesis4 ED Path(a$4 Pentoses 'hos'hate shunt A
/C- c$cle
UNIT IV J BIOENERGETICS
2es'irator$ chain4 -ero,ic and anaero,ic res'iration<
UNIT VJ PROTEINS E A#INO ACIDS #ETABOLIS# -I
-mino acids - Classi#ications4 Ph$sico = Chemical Pro'erties4 Protein structure4 #olding A #unction4 5itrogen
C$cle4 5itrogen !alance4 reducti1e amination A transamination ACrea c$cle<
UNIT VI J PROTEINS E A#INO ACIDS #ETABOLIS# -II
S$nthesis o# amino acids - 0lutamate 'ath(a$M Serine 'ath(a$M shi*imate 'ath(a$ #or the 'roduction o#
aromatic amino acids<
UNIT VII0 LIPIDS E THEIR #ETABOLIS#
Classi#ications4 Structures and roles o# #att$ acidsM #att$ acid ,rea*do(nM #att$ acid s$nthesisM s$nthesis and
meta,olism o# trigl$cerols4 cholesterol structure and #unction< +i'o'roteins = classi#ication A #unction<
UNIT VIIIJ INTER#EDIARY #ETABOLIS#
&nterconnection o# 'ath(a$s A meta,olic regulation
NUCLEIC ACIDS AND THEIR #ETABOLIS#
Structure and Pro'erties o# 'urines4 '$rimidines4 5ucleosides and 5ucleotides< !ios$nthesis and
degradation o# nucleic acids
TE.T BOO/S0
1< +ehninger -<+4 5elson 6<H+4 %<%< Co;4 Princi'les o# !iochemistr$ 3
rd
Edition4 2000 C!S
Pu,lications4 1KK3< 4
2< "undamentals o# !iochemistr$ E<+< Eain S< Chand Pu,lishers
RE1ERENCES0
1< 9oet D4 9oet E< 04 !iochemistr$4 Second Edition4 Eohn C )ile$ and Sons4 1KK<
2< +< Str$er4 E<%< !erg4 E+ /$moc*7o !iochemistr$ G
th
edition4 )3 "reemen A Co 2002<
3< !iochemistr$ ,$ F< %athe(s4 F<E< 9an 3olde4 Fe1in 0 -hern4 Pearson education<
< ProteinHs Structure and #unction< Da1iel )hit#ord Eohn )ile$ Pu,lications<
G< !iochemistr$ ,$ cristo'her F<%athe(s4 F<E<9an 3olde4 Pearsons education<
21
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4,- % 4
THER#ODYNA#ICS 1OR BIOTECHNOLOGISTS
UNIT I0 BASIC CONCEPTS IN ENGINEERING THER#ODYNA#ICS
"irst and Second la( o# thermod$namicsM Calculation o# )or*4 energ$ and 'ro'ert$ changes in re1ersi,le
'rocesses4 /hermod$namics o# #lo( 'rocessesM Po(er c$cles and re#rigeration c$cles4 2esidual 'ro'erties
UNIT II0 #ATERIAL BALANCE
Stead$ state and e?uili,rium4 t$'es o# material ,alances4 stoichiometr$ o# gro(th and 'roduct #ormation4
Electron ,alance4 /heoretical o;$gen demand
UNIT III0 ENERGY BALANCES
!asic Energ$ conce'ts4 &ntensi1e and E;tensi1e 'ro'erties4 general energ$ ,alance e?uations4 Enthal'$
calculations4 State 'ro'erties-reacti1e and non-reacti1e s$stems4 3eat o# solutions4 3eat o# com,ustion4
3eat o# reaction in non-standard conditionM Energ$ ,alance e?uation #or cell culture (ith ,asic numerical
calculations<

U42t IV0UNSTEADY-STATE #ATERIAL AND ENERGY BALANCES
Cnstead$ state material ,alance and energ$ ,alance e?uationsM Sol1ing unstead$ e?uations #or ,iological
s$stems in CS/24 #ed-,atch and 'lug #lo( reactors<
U42t V0THER#ODYNA#IC PROPERTIES O1 1LUIDS
Estimation o# thermod$namic 'ro'erties using e?uations o# stateM %a;(ell relationshi's and their
a''licationsM Calculation o# #lo( 'rocesses ,ased on actual 'ro'ert$ changes
UNIT VI0 SOLUTION THER#ODYNA#ICS
Partial molar 'ro'ertiesM conce'ts o# chemical 'otential and #ugacit$ &deal non ideal solutionsM 0i,,s Duhem
e?uationM E;cess 'ro'erties o# mi;turesM -cti1it$ Coe##icient - corm 'osition models
UNIT VII0 PHASE EKUILIBRIA
Criteria #or 'hase e?uili,riumM 9a'our-li?uid e?uili,rium calculations #or ,inar$ mi;tures4 li?uid -+i?uid
e?uili,rium and Solid-li?uid e?uili,rium
UNIT VIII0 CHE#ICAL REACTION EKUILIBRIA
E?uili,rium criteria #or homogeneous chemical reactionsM E1aluation o# e?uili,rium constant and e##ect o#
'ressure and tem'erature on e?uili,rium constantM Calculation o# e?uili,rium con1ersions and $ields #or
single and multi'le chemical reactions
TE.T BOO/S 0
1< E %<Smith43<C<9an 5ess and %<%<-,,ott< &ntroduction to Chemical Engineering
/hermod$namics %c0ra( 3ill
2<P<%<Doaran4!io'rocess Engineering Princi'les4 -cademic Press41KKG<
RE1ERENCES0
%<D<Forets*$4 Engineering and Chemical /hermod$namics4 Eohn )ile$ and sons4200
22
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4,- % 4
CELL BIOLOGY
UNIT I0 CELL STRUCTURE AND 1UNCTION
Disco1er$ o# cellsM !asic 'ro'erties o# cellsM Cell theor$M Cell com'le;it$ = Cell si7e A sha'eM Di##erent
classes o# cellsM Pro*ar$otic A Eu*ar$otic cellsM
UNIT II0 CHE#ISTRY O1 THE CELL
&m'ortance o# car,on and (aterM Plasma mem,rane- structure and #unctionM C$to'lasm M C$tos*eleton -
%icrotu,ules4 micro#ilaments A intermediate #ilaments4 cell motilit$ = cilia A #lagella
UNIT III0 INTRACELLULAR CO#PART#ENTS
Structure and #unctions o# 5ucleus4 Endo'lasmic 2eticulum4 0olgi Com'le;4 +$sosomes4 Pero;isomes4
Chloro'last A %itochondria< Protein 0l$cos$lation4 intracellular 'rotein tra##ic A /argeting<
UNIT IV0 TRANSPORT ACROSS CELL #E#BRANES
Passi1e and -cti1e /rans'ort4 Cni'ort4 S$m'ort4 -nti'ort4 Permeases4 P- /$'e A 9 - /$'e Pum's4 5a+:F+
-/Pase4 +$sosomal A 9acuolar mem,rane -/P de'endent Proton Pum's4 Endoc$tosis and E;oc$tosis4
/rans'ort into Pro*ar$otic Cells
UNIT V0 CELL DIVISION
61er1ie( o# the Cell C$cle4 &nter'hase4 %itosis4 C$to*inesis A %eiosis< -nimal Cell A Deast Cell Di1ision4
Cell C$cle Control A Chec*'oints<
UNIT VI0 CELL DI11ERENTIATION
0eneral Characteristics o# Cell Di##erentiation4 Di##erentiation in Cnicellular A %ulticellular 6rganism4
C$to'lasmic determinants4 5ucleo'lasmic &nteractionsM Em,r$onic and adult stem cells and its !iological
&m'ortance<
UNIT VII0 CELL SIGNALING - BASIC CONCEPTS
&ntracellular signaling4 t$'es o# signal rece'tors - C$tosolic4 5uclear A %em,rane ,ound rece'tors4 Chemo
rece'tors o# !acteria @-ttractants A 2e'ellentsB4 Signal /ransduction ,$ hormones - Steroid : Pe'tide
hormonesM Conce't o# Secondar$ messengers4 c-%P4 c0%P4 Protein Finases4 0 ProteinsM 2ece'tors A 5on
- rece'tors associated t$rosine *inases<
UNIT VIII0 CANCER BIOLOGY - BASIC CONCEPTS
Characteristics o# Cancer Cells4 /$'es o# /umors4 %olecular !asis o# Cancer = Proto oncogene4 /umor
Su''ressor gene4 telomerase4 a'o'tosis4 angiogenesis and metastasis4 chemical carcinogens4 cancer
thera'$<
TE.T BOO/S0
1B /he Cell ,$ Coo'er<
2B Cell and %olecular ,iolog$ = De 2o,ertis and De 2o,ertis @1KK8B )a1erl$ P1t< +td<
R(9()(4*(30
1B Cell A %olecular !iolog$ ,$ 0erald Far' @2nd Ed<B )ile$ 'u,lishers<
2B /he )orld o# the cell ,$ !ec*er4 2eece4 Poenie @3rd editionB !en8amin
Pu,lishers<
3B %olecular !iolog$ o# the cell ,$ !ruce -l,erts<
B /he ,iochemistr$ o# Cell Signalling-Ernst E<%<3elmreich< 6;#ord Press<
GB /he (orld o# Cell< Gth edition- !ec*er4 Fleinsmith4 3arden4-Pearson
Pu,lishers<
6B Cell A %olecular !iolog$ ,$ Philli' Sheeler and Donald E<!lanchi 3rd edition
Eohn )ile$ Asons
23
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4,- % 4
#ATHE#ATICS -II
UNIT ' I
%atricesJ Elementar$ ro( trans#ormations = 2an* = 5ormal #orm - Echelon #orm = Consistenc$ = Solution o#
s$stem o# simultaneous linear homogeneous and non-homogeneous e?uations<
UNIT ' II
Eigen 1alues4 Eigen 1ectors = 'ro'erties = Ca$le$-3amilton /heorem - &n1erse and 'o(ers o# a matri; ,$
Ca$le$-3amilton theorem = Diagonoli7ation o# matri;< Calculation o# 'o(ers o# matri; = %odal and s'ectral
matrices<
UNIT-III
2eal matrices = S$mmetric4 s*e( - s$mmetric4 orthogonal4 +inear /rans#ormation - 6rthogonal
/rans#ormation< Com'le; matricesJ 3ermitian4 S*e(-3ermitian and Cnitar$ = Eigen 1alues and Eigen
1ectors o# com'le; matrices and their 'ro'erties >uadratic #orms- 2eduction o# ?uadratic #orm to canonical
#orm = 2an* - Positi1e4 negati1e de#inite - semi de#inite - inde; - signature - S$l1ester la(<
UNIT 'IV
"ourier SeriesJ Determination o# "ourier coe##icients = "ourier series = e1en and odd #unctions = "ourier
series in an ar,itrar$ inter1al = e1en and odd 'eriodic continuation = 3al#-range "ourier sine and cosine
e;'ansions<
UNIT-V
"ormation o# 'artial di##erential e?uations ,$ elimination o# ar,itrar$ constants and ar,itrar$ #unctions =
solutions o# #irst order linear @+agrangeB e?uation and nonlinear @standard t$'eB e?uations<
UNIT 'VI
%ethod o# se'aration o# 1aria,les = Classi#ication o# second order linear Partial Di##erential E?uations4
solutions o# one dimensional heat e?uation4 (a1e e?uation and t(o-dimensional +a'laceHs e?uation under
initial and ,oundar$ conditions<
UNIT 'VII
"ourier integral theorem = "ourier sine and cosine integrals< "ourier trans#orms = "ourier sine and cosine
trans#orms = 'ro'erties = in1erse trans#orms = "inite "ourier trans#orms<
UNIT-VII&
L-trans#orm = in1erse 7-trans#orm - 'ro'erties = Dam'ing rule = Shi#ting rule = &nitial and #inal 1alue
theorems< Con1olution theorem = Solution o# di##erence e?uation ,$ 7-trans#orms<

TE.T BOO/S0
1< - te;t !oo* o# Engineering %athematics4 9ol-&& /< F< 9< &$engar4 !< Frishna 0andhi and 6thers4 S<
Chand A Com'an$<
2< - te;t !oo* o# Engineering %athematics4 C< San*araiah4 9< 0< S< !oo* +in*s<
3< - te;t !oo* o# Engineering %athematics4 Shahna7 !athul4 2ight Pu,lishers<
< - te;t !oo* o# Engineering %athematics4 P< 5agesh(ara 2ao4 D< 5arasimhulu A 5< Pra,ha*ar 2ao4
Dee'thi Pu,lications<
RE1ERENCES0
1< - te;t !oo* o# Engineering %athematics4 !< 9< 2aman4 /ata %c 0ra( 3ill<
2< -d1anced Engineering %athematics4 &r1in Fre$s7ig4 )ile$ &ndia P1t< +td<
3< - te;t !oo* o# Engineering %athematics4 /hamson !oo* Collection<
24
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4,- % 4
GENETICS
UNIT I0 PHYSICAL BASIS O1 HEREDITY
!asic la(s o# inheritance mono-h$,rid4 dih$,rid and tri-h$,rid ratios4 %odi#ication o# %endelHs ratios due to
gene interaction< %ulti'le #actors o# inheritance< 0enes and en1ironment4 identi#ication o# the genetic
materials - classical e;'eriments< 3ershe$ Chase4 -1er$ %c+eod etc4
UNIT II0 ORGANIJATION O1 GENETIC #ATERIAL
Pac*ing o# D5-4 organi7ation o# genetic material in 'ro*ar$otes4 Eu*ar$otes< Euchromatin and
3eterochromatin organi7ation o# 5ucleosomes<
UNIT III0 LIN/AGE E RECO#BINATION
Chromosomal inheritance4 the conce't o# lin*age4 c$tological ,asis o# crossing o1er< %echanism o#
recom,ination4 /ransduction 'henomena4 %ethods o# transduction4 0enerali7ed4 S'eciali7ed A -,orti1e
transduction4 !acterio'hages - l$tic A l$sogenic li#e c$cle Disco1er$4 Detection4 %olecular mechanisms o#
trans#ormation4 trans#ormation methods< !acterial con8ugation<
UNIT IV0 #APPING
/(o 'oint and three 'oint testcrosses and gene ma''ing< %a''ing o# genes ,$ tetrad anal$sis ,$ mitotic
crossing o1er<
UNIT V0 CHRO#OSO#E STRUCTURE= ORGANIJATION E ABERRATIONS
Chromosome mor'holog$4 classi#ication4 *ar$ot$ing< S'ecial chromosome4 chromosome a,errations4
origins4 t$'es and c$togenetic e##ects<
UNIT VI0 SE. DETER#INATION IN PRO/ARYOTES AND EU/ARYOTES
%echanism o# se; determination in insect @"ruit #l$B and 'lants @%elandriumB4 Se; #actors in ,acteria4 " and
3"r trans#er4 mechanism o# trans#er<
UNIT VII0 SE. DETER#INATION IN HU#ANS
Se; di##erentiation and de1elo'ments in humans4 Dosage com'ensation4 %ar$leons h$'othesis4 Se; lin*ed
disorders in human ,eings = 3aemo'hilia4 "ragile-; sndrome4
Do(nHs s$ndrome
UNIT VIII0 E.TRA CHRO#OSO#AL INHERITANCE
&ntroduction to e;tra chromosomal inheritance4 e;am'les o# e;tra chromosomal inheritance< Petite
'henot$'es in $east< Cni'arental inheritance in algae<
TE.T BOO/S
1< E<E< 0ardner4 %<E<Simmons A DP Shustad< Princi'les o# 0enetics4 1KK1<
RE1ERENCES0
1< 0enetics4 0oodenough C4 3old &nternational 1K8G
2< 0enetics ,$ 0ri##ith<
3<Princi'les o# 0enetics4 0ardner EE4 Snustad DP4 2002 2< 0enetics ,$ Stric*,erger
< Essentials o# 0enetics @&n genomics 'ros'ecti1eB4 3art(ell4 2003
G< Princi'les o# genetics-2o,ert 3</amarin4 /ata %c0ra( 3ill<
6< 0enetics #rom 0enes to 0enomes-+eland 3<3art(ell4 +ero$ 3ood4
%c 0ra( 3ill<
7< Conce'ts o# 0enetics- 9ii edition-)iliam S<Flug4 %ichael 2< Cummings<
25
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4,- % 4
#ICROBIOLOGY
UNIT I0 INTRODUCTION TO #ICROBIOLOGY
1< Disco1er$ o# microorganismsM /heor$ o# s'ontaneous generation4 0erm theor$ o# diseasesM %a8or
contri,ution and e1ents in the #ield o# %icro,iolog$< Sco'e and rele1ance o# micro,iolog$<
2< &denti#ication o# %icroorganisms - - general account< %icrodi1ersit$
UNIT II0 #AJOR GROUPS O1 #ICROORGANIS#S.
1< 0eneral characteristics o# !acteria4 -rchaea and Eu,acteria< Di1ersit$ classi#ication o# )oese et al< /hree
domains o# li#e< "i1e - *ingdom s$stem o# )hitta*er<
2< Classi#ication s$stems - Ph$logenetic4 Phenetic4 /a;onomic ran*s4 %a8or characteristics
used in /a;onom$ - %or'hological4 Ph$siological4 ecological4 !iochemical4 &mmunological4 0enetical and
%olecular<
UNIT III0 INTRODUCTION TO VIRUSES
9irus 'ro'erties4 Structure o# 9irusesM -nimal 9irolog$M Plant 9irolog$M 9iruses o# -rthro'ods4 ,acteria and
other lo(er organismsM and classi#ication o# 1iruses @!acterial4 'lant and animal re'lication (ith 1 e;am'le
eachB and -''lications o# 9irolog$ in !iotech &ndustr$4
UNIT IV0 REPLICATION O1 VIRUSES
9iral 2e'lication4 !acterial4 'lant and animal re'lication (ith 1 e;am'le each @ in case o# animal 1iruses the
teaching should include the e;am'les o# D5- and 25- 1iral re'lication and also o# those that re'licate in the
c$to'lasm and nucleusB<
UNIT V0 IDENTI1ICATION= CULTURING AND ASSAY O1 VIRUSES
&denti#ication and in 1itro culti1ation o# 1iruses< -ssa$ o# 1iruses @ !oth !acterial and animal 1irusesB
UNIT VI0 NUTRITION AND CULTIVATION
1< 5utrition o# microorganismsM nutritional classes o# micro,es4 %acro and micronutrients4 their sources and
'h$siological #unctions o# nutrients< 0ro(th #actors and their #unctions in meta,olism< -ero,ic and anaero,ic
meta,olism<
2< Culti1ation o# microorganismsM Culture media4 s$nthetic4 com'le; media4 solidi#$ing
agents4 t$'es o# media -selecti1e4 di##erential and enrichment and enriched
media4 'ure culture methods - s'read 'late4 'our 'late and strea* 'late4
s'ecial techni?ues #or culti1ation o# anaero,es<
UNIT VII 0 IDENTI1ICATION AND PRESERVATION O1 #ICROBES
1< Preser1ation o# %icroganismsJ (or*ing and 'rimar$ stoc* cultures = agarslants4 agar sta,s4 s'ore
're'aration4 use o# sterile soil4 cr$o'reser1ation4 l$o'hilisation4 -''lication and limitations o# 1arious
methods<
2< &n#luence o# en1ironmental #actors or gro(th = solutes4 (ater acti1it$4 '34 tem'erature4 o;$7en4 osomotic
'ressure4 radiation<
3< Colon$ characteristics4 staining techni?uesM "i;ation4 Princi'le d$es4 sim'le standing4 di##erential staining
s'ore staning4 #lageller straining<
< !iochemical tests = Sugar #ermentations4 &%9&C tests4 Catalase 'roduction etc<
UNIT VIII 0 #EDICAL BIOTECHNOLOGY
Disease causing microorganisms4 %olecular !asis o# 'athogenecit$ and identi#ication methods @ #or at least
6 im'ortant ,acterial and 1iral in#ectionsB
TE.T BOO/S0
1< %icro,iolog$4 Pelc7ar %<E< Chan ECE and Frieg 52< /ata %c0ra( 3ill<
2< &ntroduction to %icro !iolog$ a case 3istor$ a''roach 3
rd
edition 8ohn< +< &ngraham4 Catherine -
lingraham4 /homson Pu,lications<
26
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RE1ERENCES0
1< !iolog$ o# %icro organisma< !26CF4 Prentice 3all4 &nternational &nc<
2< 0eneral %icro,iolog$< 3ons< 0<Schlege< Com,ridge uni1ersit$ 'ress<
3< 0eneral %icro,iolog$< 2oger D stanier4 %acmillan<
< 0eneral %icro,iolog$< Prescott and Dunn %c 0ra( 3ill Pu,lishers<
G< &ntroduction to micro,iolog$ = - case histor$ a''roach 3
rd
edition = 8ohn +< ingram4 Catherine -< &ngram
/homson Pu,lishers<
27
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% $ 2
BIOCHE#ISTRY LAB
1< Cnits4 9olume A )eight measurements< Concentration units4 '3 %easurement< Pre'aration o# ,u##ers4
2< >ualitati1e tests #or car,oh$drates< Estimation o# 2educing sugars ,$ the !enedictHs method<
3< >ualitati1e tests #or -mino -cids< >uantitati1e method #or -mino -cids45inh$drin method
< Protein estimation ,$ !iuret : "olinHs : !rad#ord method<
G< E;traction o# li'ids< Sa'oni#ication o# "ats<
6< Estimation o# cholesterol<
8< Estimation o# 5ucleic -cids4 Preci'itation ,$ sodium sul'hate4 /est #or ri,ose
and deo;$ri,ose sugar<
K< E;traction o# Ca##eine #rom tea lea1es<
10< 3$drol$sis o# ester using Pa'ain<
TE.T BOO/0
1< +a,orator$ %anaual in !iochemistr$ ,$ E<Ea$araman 5e( age &nternational
Pu,lications<
2< Princi'les A /echni?ues o# Practical !iochemistr$ G
th
edition< F< )ilson A E<)al*er4 Cam,ridge Cni1ersit$
Press4 2000<
EG<27:(4t3L
1< 2e#rigerator
2< Centri#uge<
3< !oiling (ater ,oth<
< Calorimeter<
G< '3 %eter<
6< )eighing !alance<
28
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CELL BIOLOGY AND #ICROBIOLOGY LAB
LABORATORY
2< &denti#ication o# -nimal4 Plant A !acterial cells<
3< %icrometr$<
< Di##erential centri#ugation and isolation o# Chloro'last A %itochondria<
G< Sterili7ation techni?ues @lecture:demonstrationsB
6< Pre'aration o# culture media @aB !roth t$'e o# media @,B Solid media
7< Culturing o# microorganismsJ @aB !roth @,B Pure culture techni?uesJ Strea*
'late4 'our 'late<
8< &solation and 'reser1ation o# ,acterial culture<
K<< &denti#ication o# microorganisms @aB Staining techni?ue @,B !iochemical
testing<
10< -nti,iotic test - Disc di##usion method4 minimum inhi,itor$ concentration<
11< %icro,iological e;amination o# (ater<
12< !iochemical tests
&%9&C test
Catalase test
Coagulase test
0elatinase test
6;idase test<
13< Determination o# !acterial gro(th ,$ tur,idometr$: colorimetr$<
1< "actors e##ecting the ,acterial gro(th = e##ects o# tem'erature o# '3<
TE.T BOO/S0
1< %icro,iological and a''lications4 +a,orator$4 %anual in 0eneral %icro,iolog$ ,$ !enson4 %c 0ra(
Pu,lications< "irst edition 2007
2< +a,orator$ manual in micro,iolog$ ,$ P< 0unase*haran4 5e(age international Pu,lishers<
RE1ERENCES 0
J.G. Ca77<*24 a48 N.S+():a4= A La;o)ato)C :a4<al= 4
t+
(82t2o4= A8823o4 E ?(3laC= III.
EKUIP#ENTS0
1< !right #ield microsco'e<
2< 6cular micrometer<
3< Stage micrometer<
< 3ot air o1en<
G< -utocla1e<
6< -nti,iotic disc<
7< +aminar air #lo( cham,er <
8< !unsen ,urner<
K< S'ectro'hotometer<
10< &ncu,ator and sha*er<
11< '3 %eter<
12< Com'ound microsco'e<
29
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II Y(a) B.T(*+ BT II-S(: T P C
4,- % 4
#ASS TRANS1ER AND SEPARATION
UNIT I0 INTRODUCTION TO #ASS TRANS1ER AND DI11USION
&ntroduction to %ass /rans#er 6'erationsM "ic*Hs +a( o# Di##usion4 0as di##usion and +i?uid di##usion @one
com'onent trans#erring to non-trans#erring com'onent and e?uimolar counter di##usion<B Di##usi1it$
estimation @Ste#anHs e;'erimentBM 'ermea,ilit$4 distri,ution o# gas and li?uid com'onents through solid4
di##usion o# ,iological solutes in li?uids4 di##usion in ,iological gels<
UNIT II0 #ASS TRANS1ER CO-E11ICIENT
De#inition o# *+4 "-t$'e4 F-t$'e coe##icients4 Dimensionless num,ers4 Sher(ood num,er4 Stanton num,er4
Schmidt num,erM estimation o# %/C #or the case (here mass is di##using #rom solid (all to ,ul* li?uid< @"lat
'lates4 c$lindrical tu,esB and #lo( 'ast single solids4 -''lication o# *+a in !iological S$stems<
UNIT III 0
&nter#ace mass trans#er4 gas 'hase controlling4 and li?uid 'hase controlling o'erations<
UNIT IV0 GAS LIKUID OPERATION - I
-,sor'tionJ De#inition4 Solu,ilities o# gases in li?uids4 single stage @one com'onent trans#erringB o'eration<
UNIT V0 GAS LIKUID OPERATION -II
DistillationJ 9+E4 single stage e?uili,rium distillation4 sim'le distillation and steam distillation o'erationM
continuous distillation @%cCa,e /hiele method onl$B<
UNIT VI0 LIKUID ' LIKUID AND SOLID 'LIKUID OPERATIONS -I
+i?uid-+i?uid e;tractionJ ++E4 t$'es o# e?uili,rium s$stem4 Singe stage e;traction4 %ulti stage cross and
counter current o'erations< Solid li?uid o'erationJ +eaching4 S+E4 Single stage leaching<
UNIT VII0 LIKUID ' LIKUID AND SOLID 'LIKUID OPERATIONS -II
-dsor'tionJ Ph$sical adsor'tion4 Chemisor'tion4 -dsor'tion h$sterisis4 adsor'tion isotherm4 Single stage
o'eration4 "i;ed ,ed adsor'tion4Case Studies (ith immo,ili7ed cell:en7$me s$stems
UNIT VIII0 #E#BRANE SEPARATION PROCESSES
Dial$sisM 3emodial$sisM 0as 'ermeation 'rocess4 introduction to t$'es o# #lo( in gas 'ermeationM hollo( =
#i,er se'aration assem,l$4 re1erse osmosis4 a''lication o# re1erse osmosis4 introduction o# ultra #iltration
'rocesses and micro #iltration 'rocesses<
TE.T BOO/S0
1< 2o,ert E< /re$,al4 %ass /rans#er 6'erations &&& Edition4 %c< 0ra( 3ill &nternational. YEAR
2< Christi E< 0ean*o'lis4 /rans'ort 'rocess A Cnit o'erations4 &ll ed<4 Prentice 3all &ndia P1t< +td<
3< P<%<Doran !io'rocess Engineering Princi'les4 -cademic Press 1KKG
RE1ERENCES0
1< Eudson FindJ Se'aration Processes4 && Edition4 %c 0ra( 3ill Chemical
Engineering series<
2< Phili' -< Sch(eit7er4 3and,oo* o# se'aration /echni?ues #or chemical
Engineering4 &&& Edition4 %c< 0ra( 3ill<
3< Phili' C< )an*at 2ate4 Controlled se'arations4 Cha'man and 3all4 1K8G<
30
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4,- % 4
ENVIRON#ENTAL STUDIES
UNIT - I
#<lt2823*27l24a)C 4at<)( o9 E4>2)o4:(4tal St<82(30 De#inition4 Sco'e and &m'ortance = 5eed #or Pu,lic
-(areness<
UNIT - II
Nat<)al R(3o<)*(3 0 2ene(a,le and non-rene(a,le resources = 5atural resources and associated
'ro,lems = "orest resources = Cse and o1er = e;'loitation4 de#orestation4 case studies = /im,er e;traction
= %ining4 dams and other e##ects on #orest and tri,al 'eo'le = )ater resources = Cse and o1er utili7ation o#
sur#ace and ground (ater = "loods4 drought4 con#licts o1er (ater4 dams = ,ene#its and 'ro,lems - %ineral
resourcesJ Cse and e;'loitation4 en1ironmental e##ects o# e;tracting and using mineral resources4 case
studies< - "ood resourcesJ )orld #ood 'ro,lems4 changes caused ,$ agriculture and o1ergra7ing4 e##ects o#
modern agriculture4 #ertili7er-'esticide 'ro,lems4 (ater logging4 salinit$4 case studies< - Energ$ resourcesJ
0ro(ing energ$ needs4 rene(a,le and non-rene(a,le energ$ sources use o# alternate energ$ sources<
Case studies< +and resourcesJ +and as a resource4 land degradation4 man induced landslides4 soil erosion
and deserti#ication< 2ole o# an indi1idual in conser1ation o# natural resources< E?uita,le use o# resources #or
sustaina,le li#est$les<
UNIT - III
E*o3C3t(:3 0 Conce't o# an ecos$stem< - Structure and #unction o# an ecos$stem< - Producers4 consumers
and decom'osers< - Energ$ #lo( in the ecos$stem - Ecological succession< - "ood chains4 #ood (e,s and
ecological '$ramids< - &ntroduction4 t$'es4 characteristic #eatures4 structure and #unction o# the #ollo(ing
ecos$stemJ
a< "orest ecos$stem
,< 0rassland ecos$stem
c< Desert ecos$stem
d< -?uatic ecos$stems @'onds4 streams4 la*es4 ri1ers4 oceans4 estuariesB
UNIT - IV
B2o82>()32tC a48 2t3 *o43()>at2o4 0 &ntroduction - De#initionJ genetic4 s'ecies and ecos$stem di1ersit$< -
!io-geogra'hical classi#ication o# &ndia - 9alue o# ,iodi1ersit$J consum'ti1e use4 'roducti1e use4 social4
ethical4 aesthetic and o'tion 1alues - < !iodi1ersit$ at glo,al4 5ational and local le1els< - < &ndia as a mega-
di1ersit$ nation - 3ot-s'orts o# ,iodi1ersit$ - /hreats to ,iodi1ersit$J ha,itat loss4 'oaching o# (ildli#e4 man-
(ildli#e con#licts< - Endangered and endemic s'ecies o# &ndia - Conser1ation o# ,iodi1ersit$J &n-situ and E;-
situ conser1ation o# ,iodi1ersit$<
UNIT - V
E4>2)o4:(4tal Poll<t2o4 0 De#inition4 Cause4 e##ects and control measures o# J
a< -ir 'ollution
,< )ater 'ollution
c< Soil 'ollution
d< %arine 'ollution
e< 5oise 'ollution
#< /hermal 'ollution
g< 5uclear ha7ards
Sol28 ?a3t( #a4a5(:(4t 0 Causes4 e##ects and control measures o# ur,an and industrial (astes< - 2ole o#
an indi1idual in 're1ention o# 'ollution< - Pollution case studies< - Disaster managementJ #loods4 earth?ua*e4
c$clone and landslides<
UNIT - VI
So*2al I33<(3 a48 t+( E4>2)o4:(4t 0 "rom Cnsustaina,le to Sustaina,le de1elo'ment -Cr,an 'ro,lems
related to energ$ -)ater conser1ation4 rain (ater har1esting4 (atershed management -2esettlement and
reha,ilitation o# 'eo'leM its 'ro,lems and concerns< Case Studies -En1ironmental ethicsJ &ssues and
'ossi,le solutions< -Climate change4 glo,al (arming4 acid rain4 o7one la$er de'letion4 nuclear accidents and
holocaust< Case Studies< -)asteland reclamation< =Consumerism and (aste 'roducts< -En1ironment
Protection -ct< --ir @Pre1ention and Control o# PollutionB -ct< -)ater @Pre1ention and control o# PollutionB -ct
31
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-)ildli#e Protection -ct -"orest Conser1ation -ct -&ssues in1ol1ed in en#orcement o# en1ironmental
legislation< -Pu,lic a(areness<
UNIT - VII
H<:a4 Po7<lat2o4 a48 t+( E4>2)o4:(4t 0 Po'ulation gro(th4 1ariation among nations< Po'ulation
e;'losion - "amil$ )el#are Programme< -En1ironment and human health< -3uman 2ights< -9alue Education<
-3&9:-&DS< -)omen and Child )el#are< - 2ole o# in#ormation /echnolog$ in En1ironment and human health<
-Case Studies<
UNIT - VIII
12(l8 ?o)6 0 9isit to a local area to document en1ironmental assets 2i1er :#orest grassland:hill:mountain
-9isit to a local 'olluted site-Cr,an:2ural:industrial: -gricultural Stud$ o# common 'lants4 insects4 ,irds<
-Stud$ o# sim'le ecos$stems'ond4 ri1er4 hill slo'es4 etc<
TE.T BOO/0
1< /e;t,oo* o# En1ironmental Studies #or Cndergraduate Courses ,$ Erach !harucha #or Cni1ersit$
0rants Commission<
2< En1ironmental Studies ,$ 2< 2a8ago'alan4 6;#ord Cni1ersit$ Press<
RE1ERENCE0
1 /e;t,oo* o# En1ironmental Sciences and /echnolog$ ,$ %< -n8i 2edd$4 !S Pu,lication<
32
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HYDERABAD
4,- % 4
INSTRU#ENTAL #ETHODS O1 ANALYSIS
UNIT I0 INTRODUCTION
/$'es o# -nal$tical %ethods = &nstruments #or -nal$sis = Cncertainties in &nstrumental measurements =
Sensiti1it$ and detection limit #or instruments<
UNIT II0 #ICROSCOPY
!right #ield4 Dar* #ield4 "luorescent4 Phase contrast4 con#ocal microsco'$4 SE% A /E% %icrosco'$4 "lo(
C$tometr$<
UNIT III0 CENTRI1UGATION
0eneral Princi'als4 Cltra Centri#ugation4 1elocit$ Sedimentation A measurements4 E?uili,rium
Cltracentri#ugation = Densit$ 0radient centri#ugation
UNIT IV 0 SPECTROSCOPY - I
0eneral 'rinci'les = 2adiation4 energ$ and atomic structure- t$'es o# s'ectra and their ,iochemical
use#ulness = ,asic la(s o# light a,sor'tion< Electromagnetic radiation A S'ectrum4 !eer = +am,ertHs +a(
and a''arent de1iationsM C9 - 9&S S'ectro'hotometer4S'ectro#luorimetr$4 -tomic a,sor'tion A -tomic
emission s'ectrosco'$4 Cirular Dichroism @CDB- 'rinci'les4 instrumentation and a''lications<
UNIT V0 SPECTROSCOPY-II
&n#ra 2ed S'ectrosco'$< %ass s'ectrosco'$-&ntroduction4 anal$sis4 a''lications in
,iolog$ ES2 'rinci'les - instrumentation-a''lications
UNIT VI0 ONLINE #ONITORING AND CONTROL DEVICES
'34 tem'erature4 dissol1ed o;$gen4 agitation4 sensors and their o'eration<
UNIT VI0 . RAY DI11RACTION AND CRYSTALLOGRAPHY
Princi'le4 %ode o# 6'eration and -''lications
UNIT VII0 SEPARATION EKUIP#ENTS ' PRINCIPLES AND OPERATION0
3P+C4 0as chromatogra'h$4 &on = e;change Chromatogra'h$4 0el = #iltration Chromatogra'h$4 -##init$
Chromatogra'h$4 %em,rane se'arations4 Cltra#iltration 4 2e1erse 6smosis
UNIT VIII0 N#R
3igh resolution 5%2 =Chemical shi#t-S'in-s'in cou'ling "re?uenc$ loc*- dou,le resonance-a''lications o#
'roton 5%2-?uantitati1e anal$sis-?ualitati1e anal$sis4 a''lication o# 5%2 in ,iolog$ and stud$ o#
macromolecules
TE.T BOO/S0
1< - !iologist 0uide to 'rinci'les and techni?ues o# 'ractical !iochemistr$< !$
Feith )ilson4 Fenneth 3< 0oulding 3rd ed< E+!S Series<
2< S*oog A )est4 "undamentals o# -nal$tical Chemistr$4 1K82
RE1ERENCES0
1< 9ogel4 /e;t !oo* o# >uantitati1e &norganic -nal$sis4 1KK0
2< E(ing4 &nstrumental %ethods o# -nal$sis4 1KK2
3< 3o,ert 3 )illard D< +< %erritt A E< 2< E< -< Dean4 &nstrumental %ethods o#
-nal$sis4 C!S Pu,lishers A Distri,utors4 1KK2
< "< Settle< 3and ,oo* o# &nstrumental techni?ues #or -nal$tical Chemistr$4 Prentice 3all4 1KK7<
33
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4,- % 4
#OLECULAR BIOLOGY
UNIT I0 STRUCTURE O1 DNA
Detailed structure o# D5-4 1ariation #rom )atson A Cric* model4 L - D5-4 - A ! D5-4 Denaturation A
melting cur1es<
UNIT-II0 DNA REPLICATION - I
%odels o# D5- re'licationJ semi conser1ati1e %echanism o# D5- re'lication in E.coli @,i- directionalB<
%itochondrial @D-loo'B4 9iral D5- @2olling circleB4 Single stranded- D5- 'hages @%134 V17B4
UNIT ' III 0 DNA REPLICATION- II
Eu*ar$otic telomeres and its re'lication &nhi,itors o# D5- 2e'lication< En7$mes in1ol1ed in re'lication4 ste'
,$ ste' 'rocess<
UNIT IV0 RNA STRUCTURE AND BIOSYNTHESIS
m-25-4 r-25-4 t-25- structures4 /ranscri'tion a''aratus4 25- 'ol$merases and 'roteins in1ol1ed in
transcri'tion @initiation4 elongation and termination ste'sB
UNIT V 0 POST TRANSCRIPTIONAL PROCESSING
Post transcri'tional 'rocessing o# 25- Qs t-25-4 r-25-4 m- 25- s'licing< &nhi,itors o# transcri'tion<
UNIT VI0 PROTEIN BIOSYNTHESIS
/he genetic code and )o,,le 3$'othesis4 Codon usage4 Protein s$nthesis &n Pro*ar$otes<
UNIT VII 0 PROTEIN SYNTHESIS IN EU/ARYOTES
Eu*ar$otic Protein s$nthesis4 di##erences ,et(een 'ro*ar$otic and eu*ar$otic 'rotein s$nthesis4 Post
translational modi#ications< &nhi,itors o# 'rotein s$nthesis <
UNIT VIII 0 #UTAGENESIS
%utations4 s'ontaneous4 induced4 lethal4 mutagens their t$'es and actions4 classi#ication o# mutations and
their a''lications< Site - directed mutagenesis and re1erse genetics< D5- damage and re'air mechanisms<
%utagenicit$ testing using micro,ial s$stems4 -mes /ES/<
TE.T BOO/S
1< %olecular !iolog$4 Da1id "rie#elder4 Eones and !artllett Pu,lishing 3ome41K87<
2ShortProtocolsin%olecular!iolog$42
nd
edition/<<%<-usu,el4!rent42<E<Fingston4D<D<%oire4E<0<Seidman4E<-<S
mith4 F<Struhl 0reen Pu,lication -ssociates and Eohn )ile$ and sons 1KK1
RE1ERENCES0
1< +odish4 3<4 !er* -<4 Li'urs*$4 S<+< %atsudaria4 P< !altimore4 D< and Darnell4 E<2003< %olecular Cell #
!iolog$4 %edia connected4 )<3< "reeman and Com'an$<
2< !io Chemistr$ and %olecular ,iolog$ ,$ )illiam 3< Ellio##< 6;#ord Pu,lications
3< Cell and %olecular ,iolog$ ,$ Phili' Sheeler Donald E<!ianchi )ile$ Pu,lishers<
< Cell and %olecular !iolog$ 1KK6< De 2o,ertis E<D<Pi and De 2o,ertis E<%<"<
! & )a1erl$ P1t< +td<4 5e( Delhi<
34
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HYDERABAD
4,- % 4
ENGINEERING PHYSICS
UNIT I
OPTICS 0 Inter#erence - Su'er'osition o# (a1es - DoungHs dou,le slit e;'eriment = Coherence - &nter#erence
in thin #ilms ,$ re#lection - 5e(tonHs rings - Di##raction - "ressnel and "raunho#er di##ractions - "raunho#er
di##raction at a Single slit = Dou,le slit - Di##raction grating - 0rating s'ectrum - 2esol1ing 'o(er o# a grating
- 2a$leighHs criterion #or resol1ing 'o(er = Polari7ation - /$'es o# Polari7ation = Dou,le re#raction = 5icol
'rism<
UNIT II
ULTRASONICS 0 &ntroduction - Production o# ultrasonic (a1es - %agnetostriction method = Pie7o electric
method - Detection o# ultrasonic (a1es - Pro'erties o# ultrasonic (a1es - Cse o# ultrasonics #or
nondestructi1e testing - -''lications o# ultrasonics<
ACOUSTICS O1 BUILDINGS0 !asic re?uirement o# acousticall$ good hall - 2e1er,eration and time o#
re1er,eration = Sa,ineHs #ormula #or re1er,eration time - %easurement o# a,sor'tion coe##icient o# a material
- "actors a##ecting the architectural acoustics and their remed$<
UNIT III
#AGNETIC PROPERTIES0 Permea,ilit$ - %agneti7ation - 6rigin o# magnetic moment = Classi#ication o#
magnetic materials - Dia4 'ara and #erro magnetism - 3$steresis cur1e - So#t and hard magnetic materials<
SUPERCONDUCTIVITY0 0eneral 'ro'erties - %eissner e##ect - Penetration de'th - /$'e & and /$'e &&
su'erconductors - "lu; ?uanti7ation = DC and -C Eose'hson e##ect =!CS /heor$ - -''lications o#
su'erconductors<
UNIT IV
CRYSTAL STRUCTURES AND .-RAY DI11RACTION0 &ntroduction -S'ace lattice - !asis - Cnit cell -
+attice 'arameter - !ra1ais lattices = Cr$stal s$stems - Structure and 'ac*ing #ractions o# Sim'le cu,ic -
!od$ centered cu,ic = "ace centered cu,ic cr$stals - Directions and 'lanes in cr$stals = %iller indices -
Se'aration ,et(een successi1e Wh * lX 'lanes - Di##raction o# Y-ra$s ,$ cr$stal 'lanes - !raggHs la( - +aue
method - Po(der method<
UNIT V
LASERS 0 &ntroduction - Characteristics o# lasers - S'ontaneous and stimulated emission o# radiation -
EinsteinHs coe##icients - Po'ulation in1ersion - 2u,$ laser - 3elium-5eon laser = C62 laser - Semiconductor
laser - -''lications o# lasers in industr$4 scienti#ic and medical #ields<
UNIT VI
1IBER OPTICS AND HOLOGRAPHY0 &ntroduction - Princi'le o# o'tical #i,er - -cce'tance angle and
acce'tance cone - 5umerical a'erture = /$'es o# o'tical #i,ers and re#racti1e inde; 'ro#iles = -ttenuation in
o'tical #i,ers - -''lication o# o'tical #i,ers = !asic 'rinci'les o# hologra'h$ = Construction and reconstruction
o# image on hologram = -''lications o# hologra'h$<
UNIT VII
DIELECTRIC PROPERTIES0 &ntroduction - Dielectric constant - Electronic4 ionic and orientational
'olari7ations - &nternal #ields in solids = Clausius - %ossotti e?uation = Dielectrics in alternating #ields =
"re?uenc$ de'endence o# the 'olari7a,ilit$ - "erro and Pie7o electricit$<
THER#AL PROPORTIES 0 &ntroduction - S'eci#ic 3eat o# Solids = Einstein %odel = De,$e %odel = +attice
9i,rations = Phonons = /hermal Conducti1it$<
UNIT VIII
SCIENCE E TECHNOLOGY O1 NANO#ATERIALS0 &ntroduction to 5ano materials - !asic 'rinci'les o#
5anoscience A /echnolog$ = "a,rication o# nano materials = Ph$sical A chemical 'ro'erties o#
nanomaterials = Car,on nanotu,es = -''lications o# nanotechnolog$<
35
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TE.T BOO/S 0
. P+C32*3 Vol<:( 2 ,$ 3allida$4 2esnic* and FraneM Eohn )ile$ A Son<
2. A77l2(8 P+C32*3 2
48
Edition ,$ Dr< P< -''ala 5aidu A Dr< %< Chandra She*ar 9<0<S< !oo* lin*s<
$. E4524(()245 P+C32*3 ,$ 2<F<0aur A S<+< 0u'taM Dhan'at 2ai and Sons<
RE1ERENCES0
. Na4ot(*+4olo5C ;C %ar* 2atner and Daniel 2atner4 Pearson Education<
2. I4t)o8<*t2o4 to 3ol28 3tat( 7+C32*3 ;C C< FittelM )ile$ Eastern +td.
$. #at()2al3 S*2(4*( a48 E4524(()245 ,$ 9< 2agha1anM Prentice-3all &ndia<
4. E4524(()245 P+C32*3 ,$ Dr< %< -rumugamM -nuradha -gencies<
!. Na4o:at()2al3 ,$ -<F< !and$o'adh$a$M 5e( -ge &nternational Pu,lishers<
". E4524(()245 P+C32*3 ,$ %<5< -1adhanulu A P<0< FshirasagarM S< Chand A Com'an$ +td<
36
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HYDERABAD
4,- % 4
BIOPROCESS ENGINEERING
UNIT I0 INTRODUCTION TO BIOPROCESSES
-n o1er1ie( o# traditional and modern a''lications o# ,iotechnolog$ industr$4 outline o# an integrated
,io'rocess and the 1arious @u'stream and do(n streamB unit o'erations in1ol1ed in ,io'rocesses4
generali7ed 'rocess #lo( sheets<
UNIT II0 1ER#ENTATION PROCESSES-I
0eneral re?uirements o# #ermentation 'rocesses4 !asic design and construction o# #ermentor and ancillaries4
%ain 'arameters to ,e monitored and controlled in #ermentation 'rocessesM
UNIT III0 1ER#ENTATION PROCESSES-II
-n o1er1ie( o# aero,ic and anaero,ic #ermentation 'rocesses and their a''lication in the ,iotechnolog$
industr$4 solid-su,strate4 slurr$ #ermentation and its a''lications4 (hole cell immo,ili7ation4 ,eha1iour o#
micro,es in di##erent reactors @air li#t4 #luidi7ed4 ,atch4 continuous #ed ,atch conditionB<
UNIT IV0 #EDIA DESIGN
%edium re?uirements #or #ermentation 'rocesses4 car,on4 nitrogen4 minerals4 1itamins and other com'le;
nutrients4 o;$gen re?uirements4 medium #ormulation #or o'timal gro(th and 'roduct #ormation4 e;am'les o#
sim'le and com'le; media4 design and usage o# 1arious commercial media #or industrial #ermentations
UNIT V0 0 #ETABOLIC STOICHIO#ETRY
Stoichiometr$ o# Cell gro(th and 'roduct #ormation4 elemental ,alances4 degrees o# reduction o# su,strate
and ,iomass4 a1aila,le electron ,alances4 $ield coe##icients o# ,iomass and 'roduct #ormation4 maintenance
coe##icients<
UNIT VI0 ENERGETICS
Energetic anal$sis o# micro,ial gro(th and 'roduct #ormation4 o;$gen consum'tion and heat e1olution in
aero,ic cultures4 thermod$namic e##icienc$ o# gro(th<
UNIT VII0 /INETICS O1 #ICROBIAL GROWTH AND PRODUCT 1OR#ATION
Phases o# cell gro(th in ,atch cultures4 Sim'le unstructured *inetic models #or micro,ial gro(th4 %onod
model4 0ro(th o# #ilamentous organisms< 0ro(th associated @'rimar$B and non - gro(th associated
@secondar$B 'roduct #ormation Finetics< +eude*ing-Piret models4 su,strate and 'roduct inhi,ition on cell
gro(th and 'roduct #ormation< &ntroduction to Structured %odels #or gro(th and 'roduct #ormation<
UNIT VIII0 ENJY#E PROCESSES
Production o# en7$mes in su,merged and solid-state 'rocesses4 e;traction and 'uri#ication o# en7$mes4
methods o# characteri7ation4 s'eci#ic acti1it$ and acti1it$ de#initions<
All )(l(>a4t <42t3 ?2ll +a>( ;a32* 4<:()2*al 7)o;l(:3.
TE.T BOO/S
1< %<+<Shuler and "< *argi !io'rocess engineering4 Prentice 3all o# &ndia 1KK2<
2< P<%< Doran4 !iochemical 'rocess 'rinci'les4 -cademic Press4 1KKG<
3< 3ar1e$ )< !lanch4 Douglas S< Clar* !iochemical Engineering4 %arcecel4 De**er4 2007<
4. !aile$ 6llis4 !iochemical Engineering #undamentals4 2
nd
edition4 %c0ra(-3ill4 1K86<
G< D<0<2ao4 &ntroduction to !iochemical Engineering4 %c0ra(-3ill4200G
37
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HYDERABAD
% $ 2
BIOPROCESS ENGINEERING LAB

. ENJY#E ISOLATION AND ASSAY O1 ENJY#ATIC= ACTIVITY
E;traction o# commerciall$ im'ortant en7$mes #rom natural source De1elo'ment o# en7$me assa$sM
?uanti#ication o# en7$me acti1it$ and s'eci#ic acti1it$<
2. ENJY#E /INETICS
Estimation o# %ichaelis-%enten 'arameters4 E##ect o# '3 and tem'erature on en7$me acti1it$4 *inetics o#
inhi,ition<
$. I##OBILIJED ENJY#E REACTIONS
/echni?ues o# en7$me immo,ili7ation - matri; entra'ment4 ionic and cross lin*ingM column 'ac*ingM anal$sis
o# mass trans#er e##ects on *inetics o# immo,ili7ed en7$me reactionsM ,iocon1ersion studies (ith immo,ili7ed
- en7$me 'ac*ed = ,ed reactors<
4. #ICROBIAL CULTURE STUDIES0
0ro(th o# microorganisms4 estimation o# monodHs 'arameters<
!. SCREENING O1 PROCESS VARIABLES
Plac*ett-!urman design 'ractice
". DE#ONSTRATION O1 REACTOR STUDIES
!atch4 #ed-,atch4 and continuous #lo( reactor anal$sis and residence time distri,ution<

EKUIP#ENTS
1< -utocla1e<
2< '3 %eter<
3< +aminar air #lo( cham,er<
< Centri#uge<
G< Com'ound microsco'e<
6< )ater ,ath<
7< Pac*ed-,ed reactor<
8< Sha*er-incu,ator<
K< +$o'hili7er<
10< S'ctro#lurimeter<
11< C<9< 9isi,le s'ectro'hotometer<
12< 3ot air o1en<
13< &ncu,ator<
1< Petri 'lates<
1G< %icro'i'ettes<
16< !ioreactor

38
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HYDERABAD
% $ 2
INSTRU#ENTAL #ETHODS O1 ANALYSIS LAB
1< Demonstration o# 1ia,le cells using 'hase contrast microsco'$<
2< 9eri#ication o# +am,ert = !eers +a( ,$ C9 = 9&S s'ectro'hotometer4 scanning<
3< Estimation o# di##erent macromolecules ,$ 1isi,le s'ectro'hotometer<
< Estimation o# tur,idit$ using C9-9&S s'ectro'hotometer<
G< Emission s'ectra o# -nthracene using S'ectro#luorimeter<
6< Estimation o# 'roteins A nucleic acids ,$ C<9< method<
7< Se'aration o# di##erent macromolecules ,$ Pa'er4 /hin la$er A 3P+C
chromatogra'h$<
8< %em,rane se'aration-dial$sis and ultra#iltration<
2E"E2E5CES
1< &<D<Cam',ell and 2</<D(e*4 !iological S'ectrosco'$4 !en8ameer Cunmei, A Co<4 1K86<
2< "< Settle< 3and,oo* o# &nstrumental /echni?ues #or -nal$tical Chemistr$4 Prence 3all4 1KK7<
3< )<!otton4 &nstrumentation and Process %easurements4 Cni1ersit$ Press4 1KK3<
EG<27:(4t3
1< C<9 <9isi,le s'ectro'hotometer
2< S'ectro#lourimeter<
3< 3P+C
< Chromatogra'hic cham,er<
G< %icrosco'e
6< Dial$sis ,ags<
7< %agnetic stirrer (ith magnetic ,eads
39
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HYDERABAD
III Y(a) B.T(*+ BT I-S(: T P C
4,- % 4
TRANSPORT PHENO#ENA IN BIOPROCESSES
U42t I0 #o:(4t<: T)a437o)t-I
%echanism o# %omentum /rans'ortJ 5e(tonHs +a( o# 9iscosit$4 5on- 5e(tonian #luids4 theor$ o# 1iscosit$ o#
li?uids4 time de'endant 1iscosit$4 1iscosit$ measurement @ cone-and-'late 1iscometer4 coa;ial c$linder
rotar$ 1iscometer4 im'eller 1iscometer B4 use o# 1iscometers (ith ,iological reaction #luids4 rheological
'ro'erties o# #ermentation ,roth4 #actors a##ecting ,roth 1iscocit$ @ cell concentration4 cell mor'holog$4
osmotic 'ressure4 'roduct and su,strate concentration B4 9elocit$ distri,ution in laminar #lo( and tur,ulent
#lo(
U42t II0 #o:(4t<: T)a437o)t-II
E?uation o# change #or isothermal s$stem @ e?uation o# continuit$4 e?uation o# motion4 e?uation o#
mechanical energ$ B4 inter'hase trans'ort in isothermal s$stems @ #riction #actors #or #lo( in tu,es and in
'ac*ed columns B mi;ing4 mi;ing mechanism4 'o(er re?uirements in ungassed 5e(tonian and 5on
5e(tonian #luids4 gassed #luids4 interaction ,et(een cell and tur,ulent Eddies4 o'erating conditions #or
tur,ulent shear damage< %acrosco'ic !alances- mass4 momentum and mechanical energ$ ,alances<
U42t III0 E4()5C T)a437o)t-I
/hermal conducti1it$ and the mechanisms o# energ$ trans'ort- measurement o# thermal conducti1it$4
"ourierHs la(4 stead$ state conduction4 analog$ ,et(een heat and momentum trans#er
U42t IV0 E4()5C T)a437o)t-II
/em'erature distri,ution (ith more than one inde'endent 1aria,les- heating in a semi in#inite and #inite
sla,4tem'erature distri,ution in tur,ulent #lo(- re#erence to stirred tan* reactor4 relationshi' ,et(een heat
trans#er4 cell concentrations and stirring conditions
U42t V0 #a33 T)a437o)t I
Di##usi1it$4 theor$ o# di##usion4 analog$ ,et(een mass heat and momentum trans#er4 role o# di##usion in
,io'rocessing4 #ilm theor$4 concentration distri,ution (ith more than one inde'endent 1aria,le- unstead$
di##usion4 ,oundar$ la$er theor$4 concentration distri,ution in tur,ulent #lo(- Corrsin e?uation
U42t VI0 #a33 T)a437o)t II
De#inition o# ,inar$ mass trans#er coe##icients4 trans#er coe##icients at high mass trans#er rates- ,oundar$
la$er theor$4 'enetration theor$
U42t VII0 #a33 T)a437o)t III
Con1ecti1e mass trans#er4 +i?uid -solid mass trans#er4 li?uid-li?uid mass trans#er4 gas-li?uid mass trans#er
U42t VIII0 O@C5(4 T)a437o)t
6;$gen u'ta*e in cell cultures4 "actors a##ecting cellular o;$gen demand4 o;$gen trans#er #rom gas ,u,,les
to aero,ic culture4 o;$gen trans#er in #ermentors- ,u,,les4 #actors a##ecting o;$gen trans'ort- s'arging4
stirring4 medium 'ro'erties4 anti#oam agents4 tem'erature4 mass trans#er correlations4 measurements o# *+a
- o;$gen ,alance method4 d$namic method<
Not(0 I4 all <42t3 )(l(>a4t ;a32* 4<:()2*al 7)o;l(:3 3+o<l8 ;( 7)a*t2*(8
TE.T BOO/S
2<!<!ird4 )<E<Ste(art4 E<5<+ight#oot4 /rans'ort Phenomena4 Eohn (ile$ and sons4
Singa'ore 4 1KK
2 P<%<Doran4 !io'rocess Princi'les4 -cademic Press4 1KKG
3 3ar1e$ )< !lanch4 Douglas S< Clar* !iochemical Engineering4 %arcecel4 De**er4 2007<
RE1ERENCE BOO/
1 %<+<Shuler and "< Fargi4 !io'rocess EngineeringJ !asic conce'ts4 2
nd
edition4 Prentice 3all o# &ndia4 2003
40
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HYDERABAD
4,- % 4
BIOCHE#ICAL REACTION ENGINEERING -I
UNIT I0 1<48a:(4tal3 o9 )(a*t2o4 (4524(()245
J
Conce't o# order4 molecularit$ o# a reaction4searching a mechanism #or a reaction4 e1aluation o# rate
constants4 #actors a##ecting reaction rates- '34 tem'erature using -rrhenius e?uation<
U42t II0R(a*t2o43 24>ol>245 *(ll3-I
0ro(th Finetics- ,atch4 #ed-,atch and continuous mode o# o'eration in reaction s$stem4 e1aluation o# *inetic
'arameters %onodHs e?uation- 'arameters4 death rate o# cell-,atch and continuous sterili7ation<
<
UNIT III0 R(a*t2o43 24>ol>245 *(ll3-II
&n#luence o# cell age distri,ution on gro(th *inetics4 e##ect o# inhi,itors4 su,strate inhi,ition4 %odels #or
inhi,ition *inetics4 E1aluation o# 'arameters in 3an-+e1ens'iel model<
U42t IV0 R(a*t2o43 24>ol>245 *(ll3-III
Stoichiometr$ o# cell gro(th and 'roduct #ormation- elemental and a1aila,le electron ,alances4 degrees o#
reduction4 maintainance coe##icient4 online data anal$sis #or measurement o# ,iochemical 'arameters4 state
and 'arameter estimation techni?ue<
UNIT V0 #<lt27l( R(a*t2o43
Parallel series4 series = 'arallel reactions4 calculation o# $ield and selecti1it$4 role o# thermod$namic
'arameters4 meta,olic #lu; anal$sis4 ,asic conce'ts o# structured model and introduction to c$,ernetic
models4 Design 'rinci'les- non isothermal reactions and 'ressure e##ects4 conce'ts o# residence time
distri,ution4 micromi;ing and macromi;ing
U42t VI0 #(*+a423:3 a48 /24(t2*3 o9 E4MC:( A*t2o4
%echanisms o# En7$me -ctionM Conce't o# acti1e site and energetics o# en7$me Finetics4 su,strate com'le;
#ormationM S'eci#icit$ o# en7$me actionM Finetics o# single su,strate reactionsM turno1er num,erM estimation o#
%ichaelis-%enten 'arameters< &m'ortance o# F%4 %ulti-su,strate reaction mechanisms and *inetics< /$'es
o# &nhi,ition- *inetic modelsM Su,strate and Product &nhi,itionM -llosteric
regulation o# en7$mesM Deacti1ation *inetics<
U42t VII0 E4MC:( I::o;2l2Mat2o4
Ph$sical and Chemical techni?ues #or en7$me &mmo,ili7ation - adsor'tion< matri;
entra'ment4 enca'sulation< cross-lin*ing< co1alent ,inding - e;am'lesM -d1antages
and disad1antages o# di##erent &mmo,ili7ation techni?ues< o1er1ie( o# a''lications
o# immo,ili7ed en7$me s$stems4 e##ect o# '34 tem'erature on immo,ili7ed reaction *inetics<
U42t VIII0 #a33 T)a439() E99(*t3 I4 I::o;2l2M(8 E4MC:( SC3t(:3 a48 D(3254 o9
E4MC:( R(a*to)3
-nal$sis o# "ilm and Pore Di##usion E##ects on *inetics o# &mmo,ili7ed En7$me
2eactionsM "ormulation o# dimensionless grou's and calculation o# E##ecti1eness
"actors4 /hiele modulus
5oteJ &n all units rele1ant ,asic numerical 'ro,lems should ,e 'racticed<
41
www.jntuworld.com
TE.T BOO/S0
3ar1e$ )< !lanch4 Douglas S< Clar* !iochemical Engineering4 %arcecel4 De**er4 2007<
6<+e1ens'iel< Chemical 2eaction Engineering 3ed edition4 (ile$4 5e($or*4 1KKK<
P<%<Doran !io'rocess Engneering 'rinci'les4 academic Press4 +ondon4 1KKG<
D<0<2ao4 &ntroduction to !iochemical Engineering4 %c0ra(-3ill4200G
F<-< 0a1hane4 Chemical 2eaction Engineering =&4 5irali Pra*ashan42006
E< 5ielsen4 E< 9illadsen and 0< +iden4 !ioreaction Engineering Princi'les4 S'ringer &nternational4 2
nd
edition4 2003<
7< 0<3ammes4 /hermod$namics and *inetics #or the ,iological sciences4 )ile$ = 9C34 2000
RE1ERENCES0
1< 3< Scott "ogler4 Elements o# Chemical 2eaction Engineering4 && Edition4 Prentice 3all o# &ndia P1t< +td<
2<< E<%< Smith4 Chemical Engineering Finetics4 %c 0ra( 3ill4 1K81<
3< %<+< Shuler and "< Fargi !io'rocess EnggnerringJ ,asic conce'ts<
<< 3<E< "romm &nitial rate En7$me *inetics4 S'ringer-1erlog< !erlin 1K7G<
42
www.jntuworld.com
HYDERABAD
4,- % 4
BASIC INDUSTRIAL AND ENVIRON#ENTAL BIOTECHNOLOGY
U42t& 0 P)o8<*t2o4 o9 P)2:a)C #(ta;ol2t(3
- ,rie# outline o# 'rocesses #or the 'roduction o# some commerciall$ im'ortant 6rganic acids @e<g< citric acid4
lactic acid4 acetic acid4 gluconic acid4BM -mino acids @0lutamic acid4 l$sine4 as'artic acidAPhen$lalanineBM
and -lcohols @ethanol4 243- ,utanediolB
UNIT II0 S(*o48a)C #(ta;ol2t(3 0
Stud$ o# 'roduction 'rocesses #or 1arious classes o# lo( molecular (eight secondar$ meta,olitesJ
-nti,iotics-,eta-lactams @PenicillinsB4 semi s$nthetic Pencillins and Ce'halos'orins amino-gl$cosides
@stre'tom$cinB4 macrolids @er$throm$cinB4 ?uinines4 and aromatics< 9itamin @!12B and Steroids4 dual
or multi'le #ermentation<
U42t III0 P)o8<*t2o4 o9 Co::()*2allC I:7o)ta4t E4MC:(3
Proteases4 -m$lases +i'ases4 Cellulases4 Pectinases4 &somerases and other commerciall$ im'ortant<
En7$mes #or the #ood 'harmaceutical industriesM
UNIT IV 0 R(*o:;24a4t P)ot(243
Production o# recom,inant 'roteins @&nsulin4 &nterleu*in A &nter#eronHs B ha1ing thera'eutic and diagnostic
a''licationsM 'roduction o# 1accines<
U42t V 0 B2o 7)o8<*t3 a48 ot+() P)o*(33(3
5atural !io'reser1ati1es @5isinB4 and !io'ol$mers @Yanthan 0um and P3!BM Single Cell Protein4
2acemicall$-'ure Drug &ntermediates4 Steroid !iocon1ersionsM 3igh -"ructose Corn s$ru'M !iocon1ersion o#
9egeta,le 6ils4 !ioleaching<
U42t VI 0 B2olo52*al t)(at:(4t o9 ?a3t( Wat() ' A()o;2* a48 A4a()o;2* SC3t(:3
!iological 'rocesses #or domestic and industrial (aste (ater treatmentsM -ero,ic s$stems - acti1ated sludge
'rocess4 tric*ling #ilters4 ,iological #ilters4 rotating ,iological contractors @2!CB4 "luidi7ed ,ed reactor @"!2B4
e;'anded ,ed reactor4 &n1erse #luidi7ed ,ed ,io#ilm reactor @&"!!2B 'ac*ed ,ed reactors air- s'arged
reactors M -naero,ic S$stems - contact digesters4 'ac*ed column reactors4 C-S!<
U42t VII0 B2o)(:(82at2o4
&ntroduction4 constraints and 'riorities o# !ioremediation4 !iostimulation o# 5aturall$ occurring micro,ial
acti1ities4 !ioaugmentation4 in situ4 e; situ4 intrinsic A engineered ,ioremediation4Solid 'hase ,ioremediation
- land #arming4 're'ared ,eds4 soil 'iles4 Ph$toremediation< Com'osting4 !io1enting A !ios'argingM +i?uid
'hase ,ioremediation - sus'ended ,ioreactors4 #i;ed ,io#ilm reactors<
U42t VIII0 HaMa)8o<3 Wa3t( #a4a5(:(4t
&ntroduction - Yeno,iotic com'ounds4 recalcitrance< ha7ardous (astes - ,iodegradation o# Yeno,iotics <
!iological deto;i#ication - ha7ardous (aste management (ith at least 3 = E;am'les<
TE.T BOO/S0
!iotechnolog$4 3rd edition ,$ Eohn E< Smith< Cam,ridge lo( 'rice editions<
&ndustrial %icro,iolog$J - E< E< CasidaM
3 En1ironmental !iotechnolog$ ,$ S< F< -gar(al
!iodegradation A !ioremediation @1KKKB4 %artin -le;ander4 -cademic 'ress<
RE1ERENCES0
1<%icro,iolog$J - Prescott and Dunn<
2<%icro,ial ,iotechnolog$J 0la7er4 -<5< and 5i*aido4 3< 1KKG )<3< "reeman ACom'an$4 5e( Dor*<
3< &ndustrial %icro,iolog$J- -< 3< Patel<< Stanier 2< D<4 &ngram E<+<4 )heelis %<+<4 Painter 2<2<4 0eneral
%icro,iolog$ %c%illan Pu,lications4 1K8K<
< "oster C<"<4 Eohn )are D<-<4 En1ironmental !iotechnolog$4 Ellis 3or(ood +td<41K87<
G< Farrel$ D<4 Cha*ra,art$ F<4 6men 0<S<4 !iotechnolog$ and !iodegradation4
6< -d1ances in -''lied !iotechnolog$ Series4 9ol<4 0ul# Pu,lications Co< +ondon4 1K8K<
7< !ioremediation engineeringM design and a''lication 1KKG Eohn< /< coo*son4Er< %c 0ra( 3ill4 &nc<
8< En1ironmental !iotechnolog$ ,$ -<F< Chatter8ee
K< En1ironmental !iotechnolog$ ,$ S<5<Eogdand 3imala$a Pu,lishing
43
www.jntuworld.com
HYDERABAD
4,- % 4
GENETIC ENGINEERING
U42t I0 G(4( R(5<lat2o4 a48 E@7)(332o4 24 P)o6a)Cot(3
+actose4 -ra,inose and /r$'to'han o'erons4 2e'ressors and acti1ator4 Sigma s(itch in 3acillus subtilis.
U42t II0 G(4( R(5<lat2o4 24 E<6a)Cot2* 3C3t(:
0ene regulation in Eu*ar$otic s$stem4 2e'etiti1e D5-4 0ene rearrangement4 Promoters4 enhancer
elements4 gene am'li#ication<
U42t III0 Pla3:283= T)a437o3o43 / V(*to)3 9o) G(4( T)a439()3
PlasmidsJ De#inition4 t$'es4 &denti#ication4 classi#ication and 'uri#ications and trans#er o# Plasmids< 3ost
restriction in trans#er< /rans'osa,le elementsJ De#inition4 detection o# trans'osition in ,acteria4 t$'es o#
,acterial trans'osons4 mechanisms o# trans'osition and e;cision4 a''lications o#
trans'osons< 2etrotrans'osons<
UNIT IV0 DNA T(*+4olo5C
Puri#ication o# genomic D5- #rom li1ing cells4 %ani'ulation o# 'uri#ied D5-M construction o# 'rotot$'e 1ector
@'!2 322B4 di##erent t$'es o# cloning 1ectors @'lasmid = 'CC 1K4 U 'hage4 cosmid4 %13B< En7$mes in1ol1ed
in genetic engineeringM cloning
strategies4 &ntroduction o# D5- into li1ing cells< %ethods o# 0ene trans#er4 2estriction ma''ing<
UNIT ' V E@7)(332o4 a48 D(t(*t2o4 o9 *lo4(3
Detection o# clones and its e;'ressionJ E;'ression o# cloned genes in $east A E. coli. !lot anal$sis -
Southern4 5orthern A )estern ,lotM dot and slot ,lot< &mmunological techni?ues< D5- meth$lation4 D5-
h$,ridi7ation< 0enomic and cD5- li,rar$ construction and a''lication< D5- se?uencing<
U42t VI0 PCR a48 2t3 a77l2*at2o4
Princi'les4 designing o# 'rimers4 PC2 methodolog$4 2/ - PC24 multi'le; PC24 identi#ication o# PC2 'roduct4
a''lication o# PC2 technolog$<
U42t VII0 #ol(*<la) :a)6()3
%olecular mar*ersJ 2"+P4 2-PD4 -"+P4 16s r-25- t$'ing4 gene chi' and micro arra$M a''lications in
disease 'ro#ile
U42t VIII0 A77l2*at2o43 o9 )-DNA T(*+4olo5C
0ene cloning in medicine @&nsulin4 !lood clotting #actor 9&&&B 3igh le1el e;'ression o# 'roteins in di##erent
host s$stems @E. coli4 $east4 &nsect4 mammalian cellsB +imitation and ad1antages and no1el technologies- #or
generation o# transgenic animals< &ntroduction to 0ene thera'$ @E; 1i1o A &n 1i1oB4 case stud$ o# -D- as an
e;am'le< -d1antages and limitations o# 0ene thera'$<
TE.T BOO/S0
1< 6ld 2)4 Primrose S!4 'rinci'les o# 0ene mani'ulation4 -n introduction to 0enetic engineering4 !lac*(ell
Scienti#ic Pu,lications4 1KK3
2< /<-< !ro(n4 0ene Cloning<
RE1ERENCES0
1< -nsu,el "%<4 !rent -4 Fingston -E4 %oore D64 Current 'rotocols in %olecular !iolog$4 0reene Pu,lishing
-ssociates4 5D4 1K88<
2< !erger S+4 Fimmer -24 %ethods in En7$molog$4 9ol 1G24 -cademic Press4 1K87<
3< %olecular Cell !iolog$ = 0erald Car'<
44
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HYDERABAD
4,- % 4
PLANT BIOTECHNOLOGY
UNIT I TISSUE CULTURE
&ntroduction to cell and tissue cultureM /issue culture media @com'osition4 're'arationBM &nitiation and
maintenance o# callus and cell sus'ension culture4 Somatic em,r$ogenesis4 organogenesisM Proto'last
isolation culture and #usionM
UNIT II TISSUE CULTURE APPLICATIONS I
Production o# ha'loids4 Somaclonal 1ariations4 0erm'lasm conser1ation @Cr$o'reser1ationBM
UNIT III TISSUE CULTURE APPLICATIONS II
Production o# secondar$ meta,olites #rom 'lant cell culturesM Processes #or enhancing the 'roduction o#
secondar$ meta,olites< /echnolog$ o# 'lant cell culture #or 'roduction o# chemicalsM !ioreactors s$stems and
models #or mass culti1ation o# 'lant cellsM
UNIT IV PLANT TRANS1OR#ATION TECHNOLOGY
-gro,acterium mediated gene trans#erM -gro,acterium ,ased 1ectors4 1iral 1ectors and their a''lication<
Direct gene trans#er methodsM chemical methods4 electro'oration4 microin8ection4 'article ,om,ardment<
UNIT V PLANT GENETIC ENGINEERING 1OR PRODUCTIVITY AND
PER1OR#ANCE I ABIOTIC STRESSB
3er,icide resistance4 &nsect resistance4 Disease resistance4 1irus resistance4<
UNIT VI PLANT GENETIC ENGINEERING 1OR PRODUCTIVITY AND
PER1OR#ANCE II AABIOTIC STRESSB
-,iotic stress tolerance MDrought4 tem'erature4 salt <
UNIT VII #OLECULAR 1AR#ING E INDUSTRIAL PRODUCTS
-''lication o# Plant ,iotechnolog$ #or the 'roduction o# ?ualit$ oil4 &ndustrial en7$mes4 /hera'eutic Proteins 4
-ntigens @edi,le 1accineB and 'lanti,odies<
UNIT VIII #ETABOLIC ENGINEERING
%eta,olic engineering #or 'lant 'rimar$ meta,olites and secondar$ meta,olites<
TE.T BOO/S0
1< 2o,erta Smith4 Plant /issue CultureJ /echni?ues and E;'eriments< 2nd ed<4 -cademic Press4 2000<
2< !ho8(ani4 S<S< and 2a8dan4 Plant /issue CultureJ /heor$ and Practice< 200
RE1ERENCES0
1< Cris'eels4 %<E< and Sada1a4 D<E<4 Plants4 0enes and Cro' !iotechnolog$4
Eones and !artlett Pu,lishers @2nd EditionB4 2003<
2< !ho(8(ani4 S<S<4 Plant /issue CultureJ -''lication and +imitations< -msterdam4
Else1ier41KK0<
3< Charles Cunningham and -ndre( E<2< Porter4 2ecom,inant Proteins #rom PlantsJ Production and
&solation o# Clinicall$
Cse#ul Com'ounds @%ethods in !iotechnolog$B4 3umana Press4 1KK7<
< !ernard 2< 0lic* and Eohn E< /hom'son4 %ethods in Plant %olecular !iolog$ and !iotechnolog$4 C2C
Press4 1KK3<
G< &< Potr$*us and 0< S'angen,erg4 4 0ene /rans#er to Plants @S'ringer +a, %anualB4 S'ringer 9erlag4 1KK7<
6< Peter %< 0ressho##4 Plant 0enome -nal$sisJ Current /o'ics in Plant %olecular !iolog$< C2C Press4 1KK<
7< Eohn 3ammond4 Peter %c0ar1e$4 9idadi Dusi,o14 Plant !iotechnolog$J 5e( Products and -''lications4
S'ringer 9erlag4 1KKK<
45
www.jntuworld.com
HYDERABAD
4,- % 4
#ANAGERIAL ECONO#ICS AND 1INANCIAL ANALYSIS
U42t I "ntroduction to #anagerial Economics!
De#inition4 5ature and Sco'e o# %anagerial Economics=Demand -nal$sisJ Demand Determinants4
+a( o# Demand and its e;ce'tions<
U42t II Elasticity o$ DemandJ De#inition4 /$'es4 %easurement and Signi#icance o# Elasticit$ o# Demand<
Demand "orecasting4 "actors go1erning demand #orecasting4 methods o# demand #orecasting
@sur1e$ methods4 statistical methods4 e;'ert o'inion method4 test mar*eting4 controlled
e;'eriments4 8udgmental a''roach to demand #orecastingB
U42t III T+(o)C o9 P)o8<*t2o4 a48 Co3t A4alC323J Production "unction = &so?uants and &socosts4 %2/S4
+east Cost Com,ination o# &n'uts4 Co,,-Douglas Production #unction4 +a(s o# 2eturns4 &nternal
and E;ternal Economies o# Scale<
Co3t A4alC3230 Cost conce'ts4 6''ortunit$ cost4 "i;ed 1s< 9aria,le costs4 E;'licit costs 9s<
&m'licit costs4 6ut o# 'oc*et costs 1s< &m'uted costs< !rea*-e1en -nal$sis @!E-B-Determination
o# !rea*-E1en Point @sim'le 'ro,lemsB- %anagerial Signi#icance and limitations o# !E-<
U42t IV I4t)o8<*t2o4 to #a)6(t3 E P)2*245 Pol2*2(30
#a)6(t 3t)<*t<)(30 /$'es o# com'etition4 "eatures o# Per#ect com'etition4 %ono'ol$ and
%ono'olistic Com'etition< Price-6ut'ut Determination in case o# Per#ect Com'etition and
%ono'ol$<
O;F(*t2>(3 a48 Pol2*2(3 o9 P)2*245- #(t+o83 o9 P)2*2450 Cost Plus Pricing4 %arginal Cost
Pricing4 Sealed !id Pricing4 0oing 2ate Pricing4 +imit Pricing4 %ar*et S*imming Pricing4
Penetration Pricing4 /(o-Part Pricing4 !loc* Pricing4 !undling Pricing4 Pea* +oad Pricing4 Cross
Su,sidi7ation<
U42t V B<324(33 E N(? E*o4o:2* E4>2)o4:(4tJ Characteristic #eatures o# !usiness4 "eatures and
e1aluation o# Sole Pro'rietorshi'4 Partnershi'4 Eoint Stoc* Com'an$4 Pu,lic Enter'rises and their
t$'es4 Changing !usiness En1ironment in Post-li,erali7ation scenario<
U42t VI Ca72tal a48 Ca72tal B<85(t245J Ca'ital and its signi#icance4 /$'es o# Ca'ital4 Estimation o# "i;ed
and )or*ing ca'ital re?uirements4 %ethods and sources o# raising #inance<
5ature and sco'e o# ca'ital ,udgeting4 #eatures o# ca'ital ,udgeting 'ro'osals4 %ethods o#
Ca'ital !udgetingJ Pa$,ac* %ethod4 -ccounting 2ate o# 2eturn @-22B and 5et Present 9alue
%ethod @sim'le 'ro,lemsB
U42t VII I4t)o8<*t2o4 to 124a4*2al A**o<4t2450 Dou,le-Entr$ !oo* Fee'ing4 Eournal4 +edger4 /rial
!alance- "inal -ccounts @/rading -ccount4 Pro#it and +oss -ccount and !alance Sheet (ith
sim'le ad8ustmentsB<
U42t VIII 124a4*2al A4alC323 t+)o<5+ )at2o30 Com'utation4 -nal$sis and &nter'retation o# +i?uidit$ 2atios
@Current 2atio and ?uic* ratioB4 -cti1it$ 2atios @&n1entor$ turno1er ratio and De,tor /urno1er
ratioB4 Ca'ital structure 2atios @De,t- E?uit$ ratio4 &nterest Co1erage ratioB4 and Pro#ita,ilit$
ratios @0ross Pro#it 2atio4 5et Pro#it ratio4 6'erating 2atio4 P:E 2atio and EPSB<
TE.T BOO/S0
1< -r$asriJ %anagerial Economics and "inancial -nal$sis4 2:e4 /%34 200G<
2< 9arshne$ A %ahes(ariJ %anagerial Economics4 Sultan Chand4 2003<
46
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RE1ERENCES0
1< -m,rish 0u'ta4 "inancial -ccounting #or %anagement4 Pearson Education4 5e( Delhi<
2< 3< Craig Peterson A )< Cris +e(is4 %anagerial Economics4 P3&4
th
Ed<
3< Suma Damodaran4 %anagerial Economics4 6;#ord Cni1ersit$ Press<
< +i'se$ A Chr$stel4 Economics4 6;#ord Cni1ersit$ Press<
G< S< -< Siddi?ui A -< S< Siddi?ui4 %anagerial Economics A "inancial -nal$sis4 5e( age &nternational S'ace
Pu,lications<
6< Domnic* Sal1atoreJ %anagerial Economics &n a 0lo,al Econom$4 th Edition4 /homson<
7< 5ara$anas(am$J "inancial -ccountingZ- %anagerial Pers'ecti1e4 P3&<
8< 2aghunatha 2edd$ A 5arasimhachar$J %anagerial EconomicsA "inancial -nal$sis4 Scitech<
K< S<5<%ahes(ari A S<F< %ahes(ari4 "inancial -ccounting4 9i*as<
10< /ruet and /ruetJ %anagerial EconomicsJ-nal$sis4 Pro,lems and Cases4 )ile$<
11< D(i1ediJ%anagerial Economics4 6th Ed<4 9i*as<
47
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HYDERABAD
% $ 2
#OLECULAR BIOLOGY AND GENETIC ENGINEERING LAB
1< &solation o# Plant and !acterial 0enomic D5- and Plasmid D5-<
2< -garose 0el Electro'horesis<
3< 2estriction En7$me digestion<
< Demonstration Chemical mutagenesis<
G< &solation and 1isuali7ation o# 'lasmid on -garose gel<
6< 2estriction ma''ing and ligation<
7< /rans#ormation4 screening #or recom,inants<
8< Characteri7ation o# secondar$ meta,olites ,$ Pol$acr$lamide gel
Electro'horesis< Sil1er staining o# 'rotein gels<
K< !lotting /echni?ues<
10< E;'ression o# !eta = galactosidase and assa$<
11< Cloning o# D5- into 'lasmid 1ector<
RE1ERENCES0
Current 'rotocols in %olecular !iolog$ ,$ %aniatis<
EKUIP#ENTS0
-utocla1e<
+aminar air #lo( cham,er<
)ater ,ath
!alance<
%icro#uge<
%icro'i'ettes
Su,marine gel electro'horesis unit (ith 'o(er 'ac*<
C<9</ransilluminator<
9ertical sla, gel electro'horesis e?ui'ment<

48
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HYDERABAD
% $ 2
ADVANCED ENGLISH CO##UNICATION S/ILLS LAB
. I4t)o8<*t2o4
/he introduction o# the English +anguage +a, is considered essential at 3
rd
$ear le1el< -t this stage the
students need to 're'are themsel1es #or their careers (hich ma$ re?uire them to listen to4 read4 s'ea* and
(rite in English ,oth #or their 'ro#essional and inter'ersonal communication in the glo,alised conte;t<
/he 'ro'osed course should ,e an integrated theor$ and la, course to ena,le students to use QgoodH
English and 'er#orm the #ollo(ingJ
0ather ideas and in#ormation4 to organise ideas rele1antl$ and coherentl$<
Engage in de,ates<
Partici'ate in grou' discussions<
"ace inter1ie(s<
)rite 'ro8ect:research re'orts:technical re'orts<
%a*e oral 'resentations<
)rite #ormal letters<
/rans#er in#ormation #rom non-1er,al to 1er,al te;ts and 1ice 1ersa<
/o ta*e 'art in social and 'ro#essional communication<
2. O;F(*t2>(30
/his +a, #ocuses on using com'uter-aided multimedia instruction #or language de1elo'ment to meet the
#ollo(ing targetsJ
/o im'ro1e the studentsH #luenc$ in English4 through a (ell-de1elo'ed 1oca,ular$ and ena,le them
to listen to English s'o*en at normal con1ersational s'eed ,$ educated English s'ea*ers and
res'ond a''ro'riatel$ in di##erent socio-cultural and 'ro#essional conte;ts<
"urther4 the$ (ould ,e re?uired to communicate their ideas rele1antl$ and coherentl$ in (riting<
$. SClla;<3J
/he #ollo(ing course content is 'rescri,ed #or the -d1anced Communication S*ills +a,J
"unctional English - starting a con1ersation = res'onding a''ro'riatel$ and rele1antl$ = using the
right ,od$ language = role 'la$ in di##erent situations<
9oca,ular$ ,uilding = s$non$ms and anton$ms4 (ord roots4 one-(ord su,stitutes4 're#i;es and
su##i;es4 stud$ o# (ord origin4 analog$4 idioms and 'hrases<
0rou' Discussion = d$namics o# grou' discussion 4 inter1ention4 summari7ing4 modulation o#
1oice4 ,od$ language4 rele1ance4 #luenc$ and coherence<
&nter1ie( S*ills = conce't and 'rocess4 're-inter1ie( 'lanning4 o'ening strategies4 ans(ering
strategies4 inter1ie( through tele and 1ideo-con#erencing<
2esumeH (riting = structure and 'resentation4 'lanning4 de#ining the career o,8ecti1e4 'ro8ecting
ones strengths and s*ill-sets4 summar$4 #ormats and st$les4 letter-(riting<
2eading com'rehension = reading #or #acts4 guessing meanings #rom conte;t4 scanning4 s*imming4
in#erring meaning4 critical reading<
/echnical 2e'ort (riting = /$'es o# #ormats and st$les4 su,8ect matter = organi7ation4 clarit$4
coherence and st$le4 'lanning4 data-collection4 tools4 anal$sis<
4. #242:<: R(G<2)(:(4t0
T+( E45l23+ La45<a5( La; 3+all +a>( t?o 7a)t30
i) T+( Co:7<t() a28(8 La45<a5( La; #or 60 students (ith 60 s$stems4 one master console4
+-5 #acilit$ and English language so#t(are #or sel#- stud$ ,$ learners<
ii) T+( Co::<42*at2o4 S62ll3 La; (ith mo1a,le chairs and audio-1isual aids (ith a P<- S$stem4
a /< 9<4 a digital stereo =audio A 1ideo s$stem and camcorder etc<
SC3t(: R(G<2)(:(4t A Ha)8?a)( *o:7o4(4tB0
omputer network with Lan with minimum 12 multimedia systems with the following specifications:
iiiB P = &9 Processor
aB S'eed = 2<8 03L
,B 2-% = G12 %! %inimum
cB 3ard Dis* = 80 0!
i1B 3ead'hones o# 3igh ?ualit$
49
www.jntuworld.com
!. S<55(3t(8 So9t?a)(0
/he so#t(are consisting o# the 'rescri,ed to'ics ela,orated a,o1e should ,e 'rocured and used<
S<55(3t(8 So9t?a)(0
Cla)2tC P)o4<4*2at2o4 Po?() = 'art &&
O@9o)8 A8>a4*(8 L(a)4()D3 Co:7a334 7
th
Edition
DELTAD3 6(C to t+( N(@t G(4()at2o4 TOE1L T(3t0 A8>a4*(8 S62ll P)a*t2*(.
L245<a TOE1L CBT I4328()4 ,$ Dreamtech
TOE1L E GRE@ F-P+-54 --2C6 A !-2265S4 CS-4 Crac*ing 02E ,$ C+&""SB
T+( 9ollo?245 3o9t?a)( 9)o: Nt)a2423<**(33.*o:D
P)(7a)245 9o) ;(245 I4t()>2(?(8=
Po32t2>( T+246245=
I4t()>2(?245 S62ll3=
T(l(7+o4( S62ll3=
T2:( #a4a5(:(4t
T(a: B<2l8245=
D(*232o4 :a6245
E45l23+ 24 #2484 3er,ert Puchta and Ee## Stran*s (ith %eredith +e1$4 Cam,ridge
". Boo63 R(*o::(48(80
1. E99(*t2>( T(*+42*al Co::<42*at2o44 %< -shra# 2i71i4 /ata %c< 0ra(-3ill Pu,lishing Com'an$
+td<
2. A Co<)3( 24 E45l23+ *o::<42*at2o4 ,$ %adha1i -'te4 Prentice-3all o# &ndia4 2007<
3. Co::<42*at2o4 S62ll3 ,$ +eena Sen4 Prentice-3all o# &ndia4 200G<
4. A*a8(:2* W)2t245- A P)a*t2*al 5<28( 9o) 3t<8(4t3 ,$ Ste'hen !aile$4 2ontledge "almer4 +ondon
A 5e( Dor*4 200<
5. E45l23+ La45<a5( Co::<42*at2o4 0 A R(a8() *<: La; #a4<al Dr - 2ama*rishna 2ao4 Dr 0
5atanam A Pro# S- San*aranara$anan4 -nuradha Pu,lications4 Chennai
6. Bo8C La45<a5(- Yo<) S<**(33 #a4t)a ,$ Dr< Shalini 9erma4 S< Chand4 2006<
7. DELTAD3 6(C to t+( N(@t G(4()at2o4 TOE1L T(3t0 A8>a4*(8 S62ll P)a*t2*(4 5e( -ge
&nternational @PB +td<4 Pu,lishers4 5e( Delhi<
8. !oo*s on TOE1L/GRE/G#AT/CAT ,$ !arronHs:cu'
9. IELTS 3()2(3 ?2t+ CD3 ,$ Cam,ridge Cni1ersit$ Press<
10. T(*+42*al R(7o)t W)2t245 To8aC ,$ Daniel 0< 2iordan A Ste1en E< Paule$4 !i7tantra Pu,lishers4
200G<
11. Ba32* Co::<42*at2o4 S62ll3 9o) T(*+4olo5C ,$ -ndra E< 2uther#ord4 2
nd
Edition4 Pearson
Education4 2007<
12. Co::<42*at2o4 S62ll3 9o) E4524(()3 ,$ Sunita %ishra A C< %urali*rishna4 Pearson Education4
2007<
13. O;F(*t2>( E45l23+ ,$ Edgar /hor'e A Sho(ic* /hor'e4 2
nd
edition4 Pearson Education4 2007<
14. Ca:;)285( P)(7a)at2o4 9o) t+( TOE1L /est ,$ Eolene 0ear A 2o,ert 0ear4
th
Edition<
15. T(*+42*al Co::<42*at2o4 ,$ %eena*shi 2aman A Sangeeta Sharma4 6;#ord Cni1ersit$ Press<
DISTRIBUTION AND WEIGHTAGE O1 #AR/SJ
Advanced Communication %&ills ab Practicals:
1< /he 'ractical e;aminations #or the English +anguage +a,orator$ 'ractice shall ,e conducted as 'er the
Cni1ersit$ norms 'rescri,ed #or the core engineering 'ractical sessions<
2< "or the English +anguage la, sessions4 there shall ,e a continuous e1aluation during the $ear #or 2G
sessional mar*s and G0 End E;amination mar*s< 6# the 2G mar*s4 1G mar*s shall ,e a(arded #or da$-to-da$
(or* and 10 mar*s to ,e a(arded ,$ conducting &nternal +a, /est@sB< /he End E;amination shall ,e
conducted ,$ the teacher concerned (ith the hel' o# another mem,er o# the sta## o# the same de'artment o#
the same institution<
50
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51
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HYDERABAD
III Y(a) B.T(*+ BT II-S(: T P C
4,- % 4
CO#PUTATIONAL #OLECULAR BIOLOGY
UNIT I0INTRODUCTION TO CO#PUTATIONAL #OLECULAR BIOLOGY
&ntroduction to acti1e areas o# research in Com'utational %olecular !iolog$4 "unctional
0enomics4 Com'arati1e 0enomics4 D$namic Programming4 0ra'hical re'resentation o# ,iochemical
s$stems4 S-s$stems e?uations4 stead$ state anal$sis4 %odel re#inements
UNIT II 0 GENO#ICS
D5- Se?uence assem,l$ and gene identi#ication< 3omolog$ ,ased gene 'rediction< S5Ps and a''lications<
%ethods o# stud$ing gene e;'ression4 ES/ a''roach4
UNIT-III #ICRO ARRAYS
!asics o# %icro arra$
UNIT IV0 PROTEO#ICS I
&ntroduction to 'roteins< Protein identi#ication4 structure and #unction determination< Structure com'arison
methods< Prediction o# secondar$ structure #rom se?uence<
UNIT V0 PROTEO#ICS II
Protein homolog$ modeling4 Protein threading< Protein a, initio structure 'rediction< Protein design
em'hasis on structural !ioin#ormatics<
UNIT VI0 TA.ONO#Y AND PHYLOGENY
!asic conce'ts in s$stematics4 %olecular e1olution4 De#inition and descri'tion o# Ph$logenetic trees and
t$'es o# trees
UNIT-VII0 DENDROGRA#S
Dendograms and its inter'retation
UNIT-VIII0 DRUG DESIGN
Drug disco1er$ c$cle4 2ole o# !ioin#ormatics in Drug disco1er$
TE.T BOO/S0
1< Da1id ) %ount< !ioin#ormatics- Se?uence and genome anal$sis< CS3+ Press<
2< Eonathan Pe1sner < !ioin#ormatics and "unctional 0enomics< - Ehon )iel$ A Sons4 &nc<4
Pu,lication
3< E<6<9oit Com'utational -nal$sis o# !iochemical s$stems4 Cam,ridge Cni1ersit$ Press
2000<
RE1ERENCES0
1< %ood$ P C E and - E )il*inson< Protein Engineering< &2+ Press<
2< Creighton / E4 Proteins< "reeman ) 3< Second edition 1KK3<
3< Eournal !&6&5"62%-/&CS @6;#ord Cni1ersit$B<
< !2-5D65D /66LE = Proteomics
52
www.jntuworld.com
HYDERABAD
4,- % 4
BIOCHE#ICAL REACTION ENGINEERING -II

UNIT I0BASIC CONCEPT
De#inition o# ,ioreactor4 #undamental 'rinci'les4 Conce't in energ$ and mass ,alances and in ,iological
reaction modeling<
UNIT II0
Classi#ication o# reactors and their con#igurations4 -''lication in su,merged #ermentation and solid state
#ermentation4 classi#ication ,ased schuegerl4 *a#aro1 com'onents o# ,ioreactors and o'eration o#
,ioreactors<
UNIT III0 ANALYSIS O1 IDEAL REACTORS
Conce'ts o# reactors ,ased on #lo( characteristics4 design o# ideal reactors using material and energ$
,alance< !atch ,ioreactor design<
UNIT IV0 CHE#OSTAT ANALYSIS
De#inition o# chemostat4 tur,idostat4 single #lo( single stage chemostat4 single #lo( multistage chemostat4
rec$cle #lo( in chemostat4 conce'ts o# dilution rate 'roducti1it$ anal$sis<
UNIT V 0 PLUG 1LOW REACTION SYSTE#
Plug #lo( ,eha1ior4 design o# 'lug #lo( reactor4 com'arison o# 'roducti1it$ in 'lug #lo( and single stage
single #lo( chemostat<
UNIT VI0 NON-IDEAL BEHAVIOUR IN REACTION SYSTE#S
2easons #or non-idealit$4 conce't o# macro using =2/D anal$sis @E-C-" #unctionsB4 diagnosing the ills o#
non-ideal ,ioreactors<
UNIT VII 0 DESIGN AND ANALYSIS O1 ENJY#E REACTORS
-''lication tu,ular reactor conce't in immo,ili7ed 'ac*ed ,ed reactors4 #luidi7ed ,ed reactors<
UNIT VIII0 SPECI1IC BIOREACTORS ANALYSIS AND SCALE-UP
Design and anal$sis o# #ed-,atch and air-li#t ,ioreactors< -''lication in animal cell culture< !asic conce't o#
scale-u'4 non-dimensional anal$sis<
T(@t Boo630
1. 6<+e1ens'iel4 Chemical 2eaction Engineering< 3
rd
edition4 )ile$ 5e($or*41KK2<
2< D<0<2ao4 &ntroduction to !iochemical Engineering4 %c0ra(-3ill4200G
3< 3<Scott "ogler Elements o# chemical reaction Engineering 3
rd
edition 4Prentice-
3all o# &ndia '1t ltd4 200
R(9()(4*(30
1< P<%<Doran !io'rocess Engineering Princi'les4 -cademic Press4 1KKG<
2< Eens 5ielsen 4Eohan 1illadsen40unnar liden4 !ioreaction Engineering 'rinci'les 2
nd
edition s'ringer 2007
53
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HYDERABAD
4,- % 4
HEAT TRANS1ER IN BIOPROCESSES
UNIT-I0BASICS O1 HEAT TRANS1ER
9arious modes o# heat trans#ers4 conduction4 con1ection4 and radiation< %echanism o# heat trans#er ,$
conduction4 conducti1e heat trans#er through a series o# resistances<
UNIT-II0CONDUCTIVE HEAT TRANS1ER0
Stead$ state and unstead$ state heat trans#er ,$ conduction< 3eat trans#er through sla, and c$linder<
Conce't o# log mean radius #or trans#er through 'i'es< E;tended sur#ace heat trans#er through #ins etc<
UNIT-III
Con1ection=Dimensional anal$sis4 "orced con1ection in 'i'e and other geometries
UNIT-IV
5atural con1ection - 1arious correlation #or e1aluating heat trans#er coe##icients<
UNIT-V
!oiling and condensations< %echanism o# ,oilingJ "ilm and nucleate ,oiling<
UNIT-VI0HEAT TRANS1ER EKUIP#ENTS
Dou,le 'i'e heat e;changers4 Shell and tu,e heat e;changers4 'in#in heat e;changers-61erall trans#er
coe##icient< 61er1ie( o# 1arious t$'es o# heat e;changers and conce't o# +%/D<
UNIT- VII
Single and %ulti'le e##ect e1a'orators and 'ro,lems on e1a'orators< Steam econom$4 Steam ca'acit$4
e1a'orators 'er#ormance (ith 1arious #eedings 1i74 #or(ard4 ,ac*(ard and 'arallel<
UNIT-VIII
-nalog$ ,et(een heat4 mass and momentum trans#er< -''lications o# heat trans#er in ,io'rocessing-,atch
sterili7ation and design o# continuous sterili7er<
* 2ele1ant ,asic numerical 'ro,lems should ,e dealt in the units<
TE.T BOO/S0
1< )<+< %c Ca,e and EC Smith4 Cnit 6'erations o# Chemical Engineering4 %c 0ra( 3ill4 G
th
edition4 1KK3<
2< P<%< Doran4 !io'rocess Engineering Princi'les4 -cademic Press4 1KKG<
RE1ERENCE BOO/S0
!&6/6+ SeriesJ /rans'ort 'henomena in ,io'rocesses4 9erlag
D<0<2ao4 &ntroduction to !iochemical Engineering4 /ata %c 0ra( 3ill4 200G<
3<)<!lanch and DS Clar*4 !iochemical Engineering4 %arced De*a1 &nc< 5e( Dor*4 1KK6<
54
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HYDERABAD
4,- % 4
INSTRU#ENTATION AND BIOPROCESS CONTROL
UNIT I0 PROCESS DYNA#ICS
Process 1aria,les-+oad 1aria,les-D$namics o# sim'le 'rocesses< "lo(4 le1el4 tem'erature and 'ressure
UNIT II0
&nteracting and non-interacting s$stem4 continuous and ,atch 'rocess-sel# - regulation-Ser1o and regulator
o'eration 'ro,lems<
UNIT III0 CONTROL ACTIONS AND CONTROLLERS
!asic control actions-characteristics o# t(o 'osition4 three 'osition4 'ro'ortional4 single s'eed #loating<
&ntegral and deri1ati1e control modes- P+&< P+D and P+&+D control modes<Pro,lems on 'neumatic4
h$draulic and electronic controllers to reali7e 1arious control actions<
UNIT IV0 OPTI#U# CONTROLLER SETTINGS
E1aluation criteria4 1:th deca$ ratio4 &-E< &SE4 &/-E- determination o# o'timum settings #or mathematicall$
descri,ed 'rocess using time res'onse and #re?uenc$ res'onse<
UNIT V0
/uning 'rocess reaction cur1e method-continuous4 oscillation method-dam'ed oscillation method-'ro,lems<
UNIT VI0 1INAL CONTROL ELE#ENT
&:P Con1erter-'neumatic4 electric and h$draulic actuators- 1al1e 'ositioner- control 1al1es-characteristics o#
control 1al1es-1al1e ,od$-0lo,e4 ,utter#l$4 dia'hragmM !all 1al1es- Control 1al1e si7ing-Ca1itation4 #lashing
'ro,lem<
UNIT VII0 #ULTI LOOP CONTROL SYSTE#
"eed #or(ard control-2atio control-Cascade control-S'lit range-%ulti1aria,le control and e;am'les #rom
distillation column A !oiler s$stem<
UNIT VIII0BIOSENSORS
/$'es4 /ransducers in ,iosensors- calorimetric4 o'tical4 'otentiometric : am'lometric4 conductometric:
resistometric4 'ie7oelectric4 semi conductor4 mechanical and molecular electromics ,ased4 molecular (ires
and s(itches4 de1elo'ment o# molecular arra$s as memor$ stores4 design #or a ,iomolecular 'hotomic
com'uters- in#ormation 'rocessing<
TE.T BOO/S0
1< Process control4 Pollard -< 3einemann4 Educational !oo*s< +ondon4 1K71<
2< Process control4 3arriott P<4 /ata %c0ra(- 'u,lishing Co< 5e( Delhi< 2e'rint 1KK1<
3< E<2< +eighJ %odeling and control in ,io'rocesses
< EE Pearson4 - 0ill and P< 9adgama4 -nal$tical as'ects o# ,iosensors4 -nnual Clinical !iochemistr$ 374
11K-1G<
< Patrana,is4 Process Control $earU
G< F2 2ogers4 %< %ascion4 !iosensors #or anal$tical monitoring EP A ,iosensors $ear
6< Donald 2< Coughano(r4 Process S$stems -nal$sis and Control4 %c0ra(-3ill41KK1
RE1ERENCES0
1< -utomatic 'rocess control4 Ec*man D<P<4 )ile$ Eastern +td< 5e( Delhi< 1KK3<
2< Chemical Process Control Ste'hanou'oulis4 0<4 Prentice 3all4 5e( Delhi<
1KK0<
55
www.jntuworld.com
HYDERABAD
4,- % 4
I##UNOLOGY
UNIT I0 THE I##UNE SYSTE#
&ntroduction4 Ph$logen$ o# the &mmune s$stem4 &nnate and ac?uired immunit$< I::<4o*+(:23t)C0
&mmunogens4 antigens4 their chemical nature4 Pro'erties in#luencing immunogenicit$4 3a'tens4 ad8u1ants<
UNIT II0 BIOLOGY O1 THE I##UNE SYSTE#
C(ll3 o9 t+( IS0 3aemato'oiesis4 l$m'hoc$te lea##ic*ing4 /4 !4 %acro'hases4 Dendritic cells4 5atural *iller
cells4 Eosino'hils4 5eutro'hils4 %ast cells and Phasoc$losis<
UNIT III0ORGANS O1 THE I.S. 0
Primar$ and Secondar$ organs o# &<S< @/h$mus4 S'leen4 +$m'hnode4 l$m'hoid #o *icle4 %-+/4 C-+/4 S-+/
UNIT IV0 HU#ORAL I##UNITY-I
!-l$m'hoc$tes4 their lineage4 &mmunoglo,ulins4 their structure #unction4 classes4 su, classes4 genetic control
o# a, 'roduction< @%aturation o# ! cellB &sot$'e4 allot$'es4 &diot$'es< -ntigen--nti,od$ intereactions4
h$'ersensiti1it$<
UNIT V0 HU#ORAL I##UNITY -II
-cti1ation o# ! cells4 their di##erentiation and e##ector #unctions< 3$,ridoma /echnolog$ %onoclonal
anti,odies their a''lication< &mmunoto;ing chimeric anti,odies and a,7$mes<
UNIT VI0 CELL #EDIATED I##UNITY
/-cells su,classes their lineage4 maturation /C2 di1ersit$4 %3C4 -g 'rocessing and 'resentation4 /-cell
arti1ation4 e##ector #unctions<
UNIT VII0 HC7()3(432t2t>2tC
3$'ersensiti1it$J /$'es o# h$'ersensiti1it$4 Princi'le4 mechanisms their rele1ance A signi#icance< 2ole o#
immune s$stem in trans'lantation4 autoimmunit$4 tumors<
UNIT VIII0 Rol( o9 2::<4( 3C3t(: 24 t)a437la4tat2o4= a<to2::<42tC= t<:o)3
/rans'lantation- 0ra#t re8ection e1idence and mechanisms o# gra#t re8ection 4're1ention o# gra#t re8ection4
immuno su''ressi1e drugs4 -utoimmunit$ = e;'erimental models o# autoimmune disease treatment o#
autoimmune disorders and /umor immunolog$<
TE.T BOO/S0
1<E< 2oitt Essential &mmunolog$4 9accines con1entional4 su,unit and
recom,inant4 antidiot$'ic 1accine4 !lac*(ell Scienti#ic 'u,lications4 6;#ord4
1KK1<
2< Fu,$ &mmunolog$4 Gth Edition < 2ichard - 0olds,$4 /homas E Findt !ar,ara -
6s,orne < ) 3 "reeman and Com'an$<
RE1ERENCES0
1< !en8amin E and +es*o(it7 S4 immunolog$ - short Course< )ile$ +&SS 5D4
1KK1<E+&S- &mmunological /echni?ues< D5- 1accines &mmunotechnolog$
2< Cellular %olecular &mmunolog$< -,ul -,,as and +itchman< 2003<
56
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HYDERABAD
4,- % 4
PROBABILITY AND STATISTICS
UNIT-I
)robability: Sample space and events 4 )robability 4 !he a"ioms of probability 4 Some
Elementar$ theorems - Conditional 'ro,a,ilit$ = !a$eHs theorem<
UNIT-II
2andom 1aria,les = Discrete and continuous = Distri,ution = Distri,ution #unction< Distri,ution
UNIT-III
!inomial and 'oison distri,utions 5ormal distri,ution = related 'ro'erties<
UNIT-IV
Sam'ling distri,utionJ Po'ulations and sam'les - Sam'ling distri,utions o# mean @*no(n and un*no(nB
'ro'ortions4 sums and di##erences<
UNIT-V
EstimationJ Point estimation = inter1al estimation - !a$esian estimation<
UNIT-VI
/est o# 3$'othesis = %eans= 3$'othesis concerning one and t(o means= /$'e & and /$'e && errors< 6ne
tail4 t(o-tail tests<
UNIT-VII
/ests o# signi#icance = StudentHs t-test4 "-test4
2
test< Estimation o# 'ro'ortions<
UNIT-VIII
>ueuing /heor$J Pure !irth and Death Process %:%:1 %odel and Sim'le Pro,lems<
T(@t Boo630
1. Pro,a,ilit$ A Statistics4 /< F< 9< &$engar4 !< Frishna 0andhi and 6thers4 S< Chand A Com'an$<
2< - te;t ,oo* o# Pro,a,ilit$ A Statistics4 Shahna7 !athul4 9< 0< S< !oo* +in*s<
R(9()(4*(30
1< Pro,a,ilit$ A Statistics4 -rnold 6< -llen4 -cademic Press<
2< Pro,a,ilit$ A Statistics #or Engineers4 %iller and Eohn E< "reund4 Prentice 3all o# &ndia<
3< Pro,a,ilit$ A Statistics4 %endan 3all4 !ea1er /homson Pu,lishers<
< Pro,a,ilit$ A Statistics4 D< F< %urugeson A P< 0uru S(am$4 -nuradha Pu,lishers<
57
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HYDERABAD
% $ 2
PLANT TISSUE CULTURE LAB
1< Pre'aration o# %edia
2< Sur#ace sterili7ation
3< Callus induction
< 6rgan culture
G< Proto'last isolation4 culture and C$tological e;amination
6< Agrobacterium mediated gene trans#er4 selection o# trans#ormants4 re'orter
gene @0CSB assa$s<
RE1ERENCE0
Plant !iotechnolog$J Practical %anual4 C<C<0iri A -rchana 0iri4 &F &nternational4 2007<
EKUIP#ENTS0
1< -utocla1e<
2< '3 %eter<
3< +aminar air #lo( cham,er<
< !<6<D< &ncu,ator<
58
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4,- % 4
I##UNOLOGY LAB
1<&mmuno'reci'itation
aB 6uchterlon$Hs immuno di##usion techni?ue<
,B Counter current immuno electro'horesis<
2< -gglutinationJ 3aemagglutination A !lood t$'ing : grou'ing<
3< En7$me lin*ed immunosor,ant assa$@E+&S-B
< &mmunoglo,ulins 'uri#ication<
G< Di##erential @&denti#ication o# cell t$'esB A /otal leu*oc$te counts o# ,lood
6< &solation A 9ia,ilit$ determination o# +$m'hoc$tes #rom 'eri'heral ,lood<
7< +$m'hoc$te 'roli#eration (ith mitogen and migration (ith ca'illar$ tu,es<
8< &denti#ication o# cell t$'es ,$ rece'tors = &mmuno#luorsence<
K< 2aising o# anti,odies in animals = Pol$clonal anti,odies<
EG<27:(4t30
1< 3aemoc$tometer
2< E+&S- reader
3< Centri#uge
< Electro'horesis unit
G< %icrosco'e
59
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HYDERABAD
IV Y(a) B.T(*+ BT I-S(: T P C
4,- % 4
BIOIN1OR#ATICS
UNIT I0 INTRODUCTION TO BIOIN1OR#ATICS
Sco'e o# !ioin#ormatics4 Elementar$ commands and 'rotocols4 #t'4 telnet4 htt'< Primer on in#ormation theor$<
UNIT-II0 INTRODUCTION TO HO#OLOGY
&ntroduction to 3omolog$ @(ith s'ecial mention to Charles Dar(in4 Sir 2ichard 6(en4 )illie 3enning4 -l#red
2ussel )allaceB<
UNIT III0 SPECIAL TOPICS IN BIOIN1OR#ATICS
D5- ma''ing and se?uencing4 %a' alignment4 +arge scale se?uencing methods Shotgun and Sanger
method<
UNIT IV 0 SEKUENCING ALIGN#ENT AND DYNA#IC PROGRA##ING
3euristic -lignment algorithms< 0lo,al se?uence alignments-5eddleman-)unsch -lgorithm Smith-
)aterman -lgorithm-+ocal se?uence alignments @-mino acid su,stitution %atrices @P-%4 !+6SC%B<
UNIT V0 PRI#ARY DATABASE AND THEIR USE
&ntroduction to !iological data,ases4 6rgani7ation and management o# data,ases< Searching and retrie1al
o# in#ormation #rom the )orld )ide )e,< Structure data,ases - PD! @Protein Data !an*B4 %olecular
%odeling Data,ases @%%D!B< Primar$ Data,ases 5C!+4E%!+4 DD!E<
UNIT-VI0 SECONDARY DATABASES
&ntroduction to Secondar$ Data,ases 6rgani7ation and management o# data,ases S(iss'rot4 P&24FE00
UNIT-VII0 BIOCHE#ICAL DATA BASES
&ntroduction to !ioChemical data,ases-organi7ation and %anagement o# data,ases< FE004 EY0ESCD4
!2E5D-4 )&/<
UNIT VIII0 EVOLUTIONARY TREES AND PHYLOGENY
%ulti'le se?uence alignment and 'h$logenetic anal$sis<
TE.T BOO/S0
1< !ioin#ormatics !asics< -''lications in !iological Science and %edicine ,$ 3ooman 3< 2ashidi and +u*as
F<!uehler C-C Press 2000<
2< -lgorithms on Strings /rees and Se?uences Dan 0us#iled< Cam,ridge Cni1ersit$ Press 1KK7<
RE1ERENCES0
1< !ioin#ormaticsJ - %achine +earning -''roach P< !aldi< S< !runa*4 %&/ Press 1K88<
2< !ioin#ormatics< Da1id %ount4 2000< CS3 Pu,lications
3< De1elo'ing !ioin#ormatics S*ills< C$nthia 0i,,as A Per Eam,er*
< 0enomics and Proteomics-"unctional and Com'utational as'ects< S'ringer Pu,lications< Editior-Sandor
Suhai<
G< !ioin#ormatics- %ethods and Protocols-3uman Press< Ste'hen %isener4 Ste'hen -< Fra(et7<
6< Com'utational !iochemistr$ = C<Stan 4/S-& )&+ED Pu,lications<
7< !ioin#ormatics = - Practical guide to the -nal$sis o# 0enes and Proteins = -5D2E-S D<!-YE9-5&S4
!<"< "2-5C&S 6CE++E//E<
8< !ioin#ormatics = Princi'les and -''lications = 3arsha(ardhan P<!al /-/- %E02-) 3&++<
K< !+-S/ J -n Essential guide &an For#4 6H2eill$ 'u,lishers<
10< !ioin#ormatics Com'uter s*ills C$nthia 0i,as 6H2eille 'u,lishers<
60
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HYDERABAD
4,- % 4
BIOETHICS= BIO SA1ETY AND INTELLECTUAL PROPERTY RIGHTS
UNIT I0 BIOETHICS
&ntroduction to !ioethics< Social and ethical issues in !iotechnolog$
UNIT II0 BIOSA1ETY I
De#inition o# !iosa#et$< !iosa#et$ #or human health and en1ironment< Social and ethical issues<
UNIT III0 BIOSA1ETY II
Cse o# geneticall$ modi#ied organisms and their release in to the en1ironment< S'ecial 'rocedures #or r-D5-
,ased 'roducts
UNIT IV0 REGULATORY A11AIRS
2egulator$ re?uirements #or drugs and !iologics< 0+P< 0%P
UNIT V0 INTELLECTUAL PROPERTY RIGHTS I
&ntellectual 'ro'ert$ rights4 and &ntellectual Pro'ert$ 'rotection4 'atents and methods o# a''lication o#
'atents4
UNIT VI0 INTELLECTUAL PROPERTY RIGHTS II
/rade Secrets co'$rights4 /rade %ar*s4 legal im'lications4 #armers rights4 'lant ,reederHs rights<
UNIT VII0 INTELLECTUAL PROPERTY RIGHTS III
&nternational and 5ational con1entions on ,iotechnolog$ and related areas<
UNIT VIII
)/6 guidelines
TE.T BOO/S0
1< Sasson -4 !iotechnologies and De1elo'ment4 C5ESC6 Pu,lications4 1K88<
2< Sasson -< !iotechnologies in de1elo'ing countries 'resent and #uture4
C5ESC6 'u,lishers4 1KK3<
RE1ERENCE0
1< Singh F< &ntellectual Pro'ert$ 2ights on !iotechnolog$4 !Cll4 5e( Delhi<
61
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HYDERABAD
4,- % 4
DOWNSTREA# PROCESSING
UNIT I0 ROLE O1 DOWNSTREA# PROCESSING IN BIOTECHNOLOGY
2ole and im'ortance o# do(nstream 'rocessing in ,iotechnological 'rocesses< Pro,lems and re?uirements
o# ,io'roduct 'uri#ication< Economics o# do(nstream 'rocessing in !iotechnolog$4 cost-cutting strategies4
characteristics o# ,iological mi;tures4 'rocess design criteria #or 1arious classes o# ,io'roducts @high 1olume4
lo( 1alue 'roducts and lo( 1olume4 high 9alue 'roductsB
UNIT-II0
Ph$sico-chemical ,asis o# ,io-se'aration 'rocesses< 2ecent de1elo'ment in 'roduct
&solation @#or e;< one ste' 'uri#ication4 re1erse %icro cellular e;traction on line mem,rane se'arationB<
UNITIII0 PRI#ARY SEPARATION AND RECOVER PROCESS
Cell disru'tion methods #or intracellular 'roducts4 remo1al o# insolu,le4 ,iomass @and 'articulate de,risB
se'aration techni?ues4 #locculation and sedimentation4 centri#ugation and #iltration methods<
UNIT IV0 #E#BRANE SEPARATIONS
%em,rane-,ased se'arations @micro and ultra#iltrationB4 theor$4 design and con#iguration o# mem,rane
se'aration e?ui'ment a''lications4
UNIT V0 ENRICH#ENT OPERATIONS
Preci'itation methods @(ith salts4 organic sol1ents4 and 'ol$mers4 e;tracti1e se'arations4 a?ueous t(o-
'hase e;traction4 su'ercritical e;tractionB4 in situ 'roduct remo1al4 integrated ,io'rocessing<
UNIT VI0 ELECTROPHORESIS
Electro'horesis o# 'roteins and nucleic acids4 1D-2D 0els4 /$'es o# Electro'horetic techni?ues @Ca'illar$
and Pulse #ieldB<
UNIT VII0 PRODUCT RESOLUTION / 1RACTIONATION
Chromatogra'hic techni?ues- Pa'er4 /+C4 -dsor'tion4 &on e;change4 0el #iltration4 a##init$ chromatogra'hic
se'aration 'rocesses4 0C4 3P+C4 "P+C4 Chromato#ocusing electro'horetic se'arations<
UNIT VIII0 NEW AND E#ERGING TECHNOLOGIES
Dial$sis4 Cr$stalli7ation Per1a'oration4 su'er li?uid e;traction #oam ,ased se'aration case stud$ (ith
e;am'les #or 'rocessing o# /(o &ndustrial Products @Citric acid : Penicillin and +o( 1olume high 1alue
'roduct li*e recom,inant 'roteinsB<
TE.T BOO/S0
1< )an*at PC< 2ate controlled se'arations4 Else1ier4 1KK0<
2< !elter P- and Cussler E< !iose'arations4 )ile$ 1K8G<
RE1ERENCES0
1< Product 2eco1er$ in !io'rocess /echnolog$4 !&6/6+<H Series4 9C34 1KK0<
2< -sen8o E<%< Se'aration 'rocesses in !iotechnolog$4 1KK34 %arcel De**ere &nc
3< %<2<+adisch4 !iose'aration engineeringJ Princi'les4 Practice and Economics4 )ile$ &nterscience 2001
62
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HYDERABAD
4,- % 4
BIOSENSORS AND BIOELECTRONICS
)hat are !iosensorsU -d1antages and limitations4 1arious com'onents o# ,iosensors
UNIT II TYPES O1 BIOSENSORS
!iocatal$sis ,ased ,iosensors4 ,ioa##init$ ,ased ,iosensors A microorganisms ,ased ,iosensors4
,iologicall$ acti1e material and anal$te< /$'es o# mem,ranes used in ,iosensor constructions<
UNIT III0 TRANSDUCERS IN BIOSENSORS I
9arious t$'es o# transducersM 'rinci'les and a''lications - Calorimetric4 o'tical4 'otentiometric :
am'erometric conductrometric:resistormetric4
UNIT IV0 TRANSDUCERS IN BIOSENSORS II
Pie7oelectric4 semiconductor4 im'edimetric4 mechanical and molecular electronics ,ased transducers<
Chemiluminiscene - ,ased ,iosensors<
UNIT V0 APPLICATION AND USES O1 BIOSENSORS I
!iosensors in clinical chemistr$4 medicine and health care4 ,iosensors #or 1eterinar$4 agriculture and #ood
UNIT VI0 APPLICATION AND USES O1 BIOSENSORS II
+o( cost- ,iosensor #or industrial 'rocesses #or online monitoringM ,iosensors #or en1ironmental monitoring<
UNIT VII0 #OLECULAR ELECTRONICS I
Potential ad1antages A De1elo'ments to(ards a ,iomolecular com'uter4 de1elo'ment o# molecular arra$s
as memor$ storesM molecular (ires and s(itchesM mechanisms o# unit assem,l$M
UNIT VIII0 DESIGN 1OR A BIO#OLECULAR PHOTONIC CO#PUTER
-ssem,l$ o# 'hotonic ,iomolecular memor$ storeM &n#ormation 'rocessingM commercial 'ros'ects #or
,iomolecular com'uting s$stems<
TE.T BOO/S0
1< -,oul - Enein4 3< 9<4 Ste#an4 2< and 9an Staden4 @1KKKB Chemiluminiscence -
,ased ,iosensors - -n o1er1ie( crit 2e1< -nal< Chem< 2K4 323-331<
2< Pearson4 E<E< 0ill4 -<4 and 9adgama4 P< @2000B -nal$tical as'ects o# ,iosensors
-nn Clin !iochem 374 11K-1G<
RE1ERENCES0
1< 2oger4 F<2< and 0erlach4 C<+< 1[KK< C'date on en1ironmental #or ,iosensors<
En1< Sci< /echnoP 33 G00- - G06-<
2< !ilite(s*i4 C< /urner4 -<P<"< 2000 !iosensors #or en1ironmental monitoring
3ar(ood4 -msterdam<
3< %oses4 9 and Ca'e4 2<E< 1KK14 !iotechnolog$ the science and ,usiness4
3ar(ood4 -cademic Pu,lisher +ondon
< 2ogers4 F<2< and %ascini4 %< 2001< !iosensors #or anal$tical monitoring EP-
,iosensors grou'<
63
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HYDERABAD
4,- % 4
BIO#ATERIAL SCIENCE AND TECHNOLOGY
AEl(*t2>( IB
De#inition o# 'ol$mers and ,iomaterials4 #unctionalit$4 'ol$mer isomerism
UNIT II0 SELECTION O1 BIO#ATERIALS
Selection criteria4 #i,er #olding4 mem,rane lamination4 in situ 'ol$meri7ation
UNIT III0 BIOLOGICALLY DERIVED BIO#ATERIALS
Pol$h$dro;ial*anoates4 'ol$lactides- characteri7ation4 s$nthesis in organism and e;traction
UNIT IV0 #ATERIALS 1OR TISSUE ENGINEERING
Case studies (ith regenerated 'ol$mers
UNIT V0 TRENDS IN BIOCO#POSITE
!iodiode 4 'ol$mer coated ,lood4 'ol$mer 'recursor s$nthesis and characteri7ation
UNIT VI0 I#PROVED 1UNCTIONS O1 BIOPOLY#ERS
0enetic and molecular !iolog$ as'ects o# s$nthesis
UNIT VII0 1ER#ENTATIVE PRODUCTION
!io'ol$ester4 micro,ial 'ol$saccharides4 micro,ial cellulose4 ,ioadhesi1e4 'ol$glutamic acid
UNIT VIII0 OPTI#IJATION O1 PRODUCTION /INETICS= SEPARATION
Statistical o'timi7ation o# 'ro,a,le 1aria,les #or 'roduction o# ,iomaterials4 use o# reactors4 *inetic anal$sis
#or 'roduction4 se'aration o# !iomaterials ,$ cell digestion and e;traction
BOO/S0
. D< !$rom4 !iomaterials =no1el materials #rom ,iological sources4 Stoc*ton 'ress4 5e( Dor*4 1KK1<
2. E<!<Par*4 !iomaterials science and engineering4 Plenum Pulo4 1K8<
RE1ERENCE BOO/0
1< -< Stein,uechel = !io'ol$mers<
64
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HYDERABAD
4,- % 4
CELL SIGNALING
AEl(*t2>( B
UNIT I0 INTRACELLULAR SIGNALING.
&ntroduction4 2ece'tor-+igand interactions<
UNIT II0 ROLE O1 RECEPTORS 'I
E;tra Cellular 2ece'tors4 Cou'lng to di##erent signal transducing s$stems<
UNIT III 0 ROLE O1 RECEPTORS 'II
/$'e o# intracellular rece'tors4 steroid rece'tors4 structure and #unction<
UNIT IV0SPECI1IC #OLECULES
2ole and #unctions o# 0-'roteins4 C2E! 'roteins4 Calcium channels4 second messengers-inositol4 diac$l
gl$cerol
UNIT V0 #ECHANIS#
Signal transduction4 mechanism and in1ol1ement o# molecules<
UNIT VI0 RECEPTORS
2egulations o# rece'tor #unction4modi#ication and ada'tation o# cells<
UNIT VII 0PATHWAYS
Signal transduction 'ath(a$s4 a''lications in de1elo'ment and diseases<
UNIT VIII 0ROLE O1 DE1ECTIVE SIGNALING
De1elo'ment o# a,normalities4 signal transducing machiner$ as targets #or 'otential drugs<
T(@t;oo63
1< 0<Posil and S</< Croo*e4 %echanism o# rece'tor regulations4 Plenum Press41K8G<
2< 2<3 0et7en,erg and E<E< !ittar4 Cell structure and signaling4 Else1ier Science4 1KK7<
65
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HYDERABAD
4,- % 4
STRUCTURAL BIOLOGY
AEl(*t2>( - IB
+e1els o# structures in !iological macromolecules4 the chiralit$ o# ,iomolecules4 'roteins4 nucleic acids4
car,oh$drates and li'ids4 co#actors4 1itamins and hormones<
UNIT II0 CON1OR#ATIONAL ANALYSIS
"orces that determine Protein and 5ucleic acid structure4 ,asic 'ro,lems< Pol$'e'tide chainsM geometric4
'otential energ$ calculations4 o,ser1ed 1alues #or rotation angles4 h$drogen ,onding4 h$dro'ho,ic
interactions and (ater structuresM ionic interactions4 disul'hide ,onds<
UNIT III0 PROTEIN 1OLDING
/$'es o# 'roteins and interactions that go1ern 'rotein #olding4 'rotein structure4 /he 'rotein glo,ule and
h$dro'hic interactionsorgani7ed #olds4 #olding mechanisms4 mem,rane 'roteins4 heli;-coil transitions4
UNIT IV0 BIO#OLECULAR INTERACTIONS
%olecular recognition4 su'ramolecular interactions4 "unctional im'ortance o# Protein'rotein and 'rotein-
nucleic acid interactions< S'eci#ic and non-s'eci#ic D5--'rotein com'le;es<
UNIT V0 STRUCTURAL ANALYSIS O1 #ACRO#OLECULES
Prediction o# 'rotein structureM Se?uence-structure relationshi's4 5ucleic acidsM general characteristics o#
nucleic acid structure4 geometric4 gl$cosidic ,ond rotational isomers ,ac*,one rotational isomers and ri,ose
'uc*ering #orces sta,ili7ing ordered #orms4 ,ase 'airing4 ,ase stac*ingM tertiar$ structure o# nucleic acids<
UNITI VI0 /INETICS O1 LIGAND INTERACTIONSJ
!iochemical Finetics studies4 uni-molecular reactions4 sim'le ,imolecular multi'le intermediates4 stead$
state *inetics4 catal$tic e##icienc$ rela;ation s'ectrometr$4 ri,onuclease as an e;am'le<
UNIT VII0 TECHNIKUES 1OR THE STUDY O1 BIOLOGICAL STRUCTURE E 1UNCTION I
Si7e and sha'e o# micro moleculesJ 'hotons4 chromo'hores4 transition di'ole moments4 a,sor,ance4 and
concentration< circular dichroismJ molecular chiralit$ and structural transitions o# macromolecules4 methods
o# direct 1isuali7ationmacromolecules as h$drod$namic 'articles - macromolecular di##usion ultra
centri#ugation 1iscometr$<
UNIT VIII0 TECHNIKUES 1OR THE STUDY O1 BIOLOGICAL STRUCTURE E 1UNCTION II
Y- ra$ cr$stallogra'h$M determination o# molecular structures4 Y- ra$ #i,er di##ractionelectron microsco'$M
neutron scattering - light scattering4 5%2 s'ectrosco'$<
T(@t Boo60
1< /inoco4 &<4 Er<4 Sauer4 F<4 )ang4 E< C<4 A Puglisi4 E< D< @2001B Ph$sical Chemistr$J
Princi'les and -''lications in !iological Sciences4 th ed< Prentice 3all<
R(9()(4*(3 0
1< &ntroduction to Protein -rchitecture4 ,$ -<%< +es*
2< &ntroduction to Protein Structure4 ,$ !randen and /oo7e
66
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HYDERABAD
4,- % 4
CANCER BIOLOGY
AEl(*t2>(-IB
UNIT I0 1UNDA#ENTALS O1 CANCER BIOLOGY
2egulation o# Cell c$cle4 mutations that cause changes in signal molecules4 e##ects on rece'tor4 signal
s(itches4
UNIT II0 TU#OR SUPPRESSION
tumour su''ressor genes4 modulation o# cell c$cle in cancer< Di##erent #orms o# cancers4 Diet and cancer<
UNIT III0 PRINCIPLES O1 CARCINOGENESIS I
Chemical Carcinogenesis4 %eta,olism o# Carcinogenesis4 5atural 3istor$ o# Carcinogenesis4 /argets o#
Chemical Carcinogenesis
UNIT IV0 PRINCIPLES O1 CARCINOGENESIS II
Princi'les o# Ph$sical Carcinogenesis4 Y - 2a$ radiation - mechanism o# radiation Carcinogenesis<
UNIT V0 #OLECULAR CELL BIOLOGY O1 CANCER
6ncogenes4 &denti#ication o# 6ncogenes4 2etro1iruses and 6ncogenes4 detection o# 6ncogenes4 0ro(th
"actor and 0ro(th "actor rece'tors that are 6ncogenes< 6ncogenes : Proto 6ncogene acti1it$< 0ro(th
#actors related to trans#ormations<
UNIT VI0 PRINCIPLES O1 CANCER #ETASTASIS
Clinical signi#icances o# in1asion4 heterogeneit$ o# metastatic 'henot$'e4 %etastatic cascade4 !asement
%em,rane disru'tion4 /hree-ste' theor$ o# &n1asion4 Proteinases and tumour cell in1asion<
UNIT VII0 DETECTION O1 CANCER
Detection o# Cancers4 Prediction o# aggressi1eness o# Cancer4 -d1ances in Cancer detection<
UNIT VIII0 NEW #OLECULES 1OR CANCER THERAPY
Di##erent #orms o# thera'$4 Chemothera'$4 radiation /hera'$4 and &mmuno thera'$J ad1antages and
limitations<
TE.T BOO/S
1< %al$ !<)<E< 9irolog$ a 'ractical a''roach4 &2+ Press4 6;#ord4 1K87<
2< Scienti#ic Pu,lications< 6;#ord4 1K88<-n &ntroduction to Cellular and %olecular !iolog$ o# Cancer4 6;#ord
%edical 'u,lications4 1KK1<
RE1ERENCE0
1< Dunmoc* 5<E and Primrose<S<!<4 &ntroduction to modern 9irolog$4 !lac*(el
67
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HYDERABAD
4,- % 4
CREATIVITY= INNOVATION AND PRODUCT DEVELOP#ENT
AEl(*t2>( - IIB
UNIT I INTRODUCTION
/he 'rocess o# technological inno1ation4 #actors contri,uting to success#ul technological inno1ation
UNIT II CREATIVITY
/he need #or creati1it$ and inno1ation4 creati1it$ Qand 'ro,lem sol1ing4 ,rain storming- di##erent techni?ues<
UNIT III PROJECT SELECTION AND EVALUATION
Collection o# ideas and 'ur'ose o# 'ro8ect<- Selection criteria - screening ideas #or ne( 'roducts @e1aluation
techni?uesB<
UNIT IV NEW PRODUCT DEVELOP#ENT
2esearch and ne( 'roduct de1elo'ment Patents - 'atent search
UNIT V0 PATENT LAWS
Patent la(s &nternational code #or 'atents - &ntellectual 'ro'ert$ rights @&P2B<
UNIT VI NEW PRODUCT PLANNING I
Design o# 'roto t$'e - testing - ?ualit$ standards
UNIT VII NEW PRODUCT PLANNING II
%ar*eting research - introducing ne( 'roducts< 0%P
UNIT VIII LABORATORY
Creati1e design - %odel Pre'aration - /esting = cost = e1aluation4 Patent a''lication- 0+P<
TE.T BOO/S
1< 3-22D !<)-//65 - 5e( Product Planning< Prentice-3all &nc< 1KK2<
2< P<5<F3-5D)-++- - "ourth E$e @E;cellence through Creati1it$B - )heeler
Pu,lishing4 -llaha,ad4 1KK2<
RE1ERENCES
1< 3-22D 5DS/26% - Creati1it$ and inno1ation -Eohn )ile$ A Sons4 1K7K<
2< !2-&5 /)&SS4 %anaging technological inno1ation4 Pitman Pu,lishing +td4
1KK2<
3< &<P<2< !ulletins< /&"-C4 5e( Delhi4 1KK7<
68
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HYDERABAD
4,- % 4
NANO BIOTECHNOLOGY
AEl(*t2>( IIB
UNIT I0 BASIC CONCEPT
De#inition o# nano scale (ith re#erence to ,ios$stems4 Sco'e and #uture 'ros'ects<
UNIT II0 TOOLS O1 NANOSCIENCE
Scanning 'ro,e instrument4 s'ectrosco'$4 electron microsco'$<
UNIT III0 TOOLS 1OR NANOSTRUCTRE
%olecular s$nthesis4 Sel# assem,l$4 Pol$merisation4 5anoscale lithogra'h$4 e-,eam lithogra'h$<
UNIT IV0 S#ART #ATERIALS
3eterogenous nano structre and com'osites4 nanoscale ,iostructres<
UNIT V0 HYBRID CO#PUTERS
Protein-h$,rid com'uters4 role o# geneticall$ engineered 'ol$mer 'roteins<
UNIT VI0 DIRECTED SYNTHESIS
%olecular ,iolog$ o# ,ios$nthesis and molecular design<
UNIT VII0 APPLICATIONS
Drugs-Photod$namic thera'$4 molecular motors4 neuroelecronic inter'hases4 de1elo'ment o#
nanoluminiscent tags<
UNIT VIII0 BIOSYNTHESIS O1 DESIGNER CO#POUNDS
Designer ,io'ol$mers4 Procollagen4 D5- Pol$node4 25- to'oisomerase4 Protein =magnetic materials<
T(@t;oo630
1< %<2atner and D<2atner45anotechnolog$ =a gentle introduction to the ne;t ,ig idea4 Pearson education 4
2007<
2< 2<2<!irge4 Proetin ,ased com'uters4 Scienti#ic -merican 4 1KKG<
R(9()(4*(30
1< +<E<"oster4 5anotechnolog$-Science4 &nno1ation and o''ortunit$ 4 Person eduction inc4 2007<
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#ETABOLIC ENGINEERING
AEl(*t2>( ' IIB
UNIT I 0 INTRODUCTION
I8(4t292*at2o4 o9 :(ta;ol2* )(5<lat2o4 23 a 6(C 7o24t 24 :(ta;ol2* (4524(()245<
!asic conce'ts o# %eta,olic Engineering = 61er1ie( o# cellular meta,olism = Di##erent models #or cellular
reactions4 induction = Eaco, %onod model and its regulation4 Di##erential regulation ,$ isoen7$mes4 "eed
,ac* regulation<
UNIT II 0 SYNTHESIS O1 PRI#ARY #ETABOLITES
-mino acid s$nthesis 'ath(a$s and its regulation at en7$me le1el and (hole cell le1el4 -lteration o# #eed
,ac* regulation4 +imiting accumulation o# end'roducts<
UNIT III 0 BIOSYNTHESIS O1 SECONDARY #ETABOLITES
2egulation o# secondar$ meta,olite 'ath(a$s4 'recursor e##ects4 'ro'hase4 idio'hase relationshi'4
Cata,olite regulation ,$ 'assing control o# secondar$ meta,olism4 'roducers o# secondar$ meta,olites4
a''lications o# secondar$ meta,olites<
UNIT IV 0 BIOCONVERSIONS
-''lications o# !iocon1ersions4 "actors a##ecting ,iocon1ersions4 S'eci#icit$4 Dields4 Co meta,olism4 Product
inhi,ition4 mi;ed or se?uential ,iocon1ersions4 Con1ersion o# insolu,le su,stances<
UNIT V 0 REGULATION O1 ENJY#E PRODUCTIO4
Strain selection4 0enetic im'ro1ement o# strains4 0ene dosage4 meta,olic 'ath(a$ mani'ulations to
im'ro1e #ermentation4 "eed ,ac* re'ression4 Cata,olite 2e'ression4 o'timi7ation and control o# meta,olic
acti1ities< /he modi#ication o# e;isting - or the introduction o# entirel$ ne( - meta,olic 'ath(a$s
UNIT VI 0 #ETABOLIC 1LU.
&ntegration o# ana,olism and cata,olism4 meta,olic #lu; distri,ution anal$sis,io'rocess4 material ,alance4
*inetic t$'es4 e?uili,rium reaction< E;'erimental determination method o# #lu; distri,ution4 %eta,olic #lu;
anal$sis and its a''lications4 /hermod$namics o# cellular 'rocesses
UNIT VII 0 #ETABOLIC ENGINEERING WITH BIOIN1OR#ATICS
%eta,olic 'ath(a$ modeling4 -nal$sis o# meta,olic control and the structure
meta,olic net(or*s4 %eta,olic 'ath(a$ s$nthesis algorithms4
UNIT VLLL 0 APPLICATIONS O1 #ETABOLIC ENGINERRING
-''lication in 'harmaceuticals4 chemical ,io'rocess4 #ood technolog$4 agriculture4
en1ironmental ,ioremediation and ,iomass con1ersion<
TE.T BOO/S0
1< )ang<D<&<C Coone$ C<+<4 Demain -<+<4 Dunnil<P< 3um'hre$ -<E< +ill$ %<D<4
"ermentation and En7$me /echnolog$4 Eohn )ile$ and sons 1K80<
2< Stan,ur$ P<"<4 and )hita*er -<4 Princi'les o# "ermentation /echnolog$4
Pergamon Press4 1K8<
R(9()(4*(3 0
Lu,a$ 0<4 !iochemistr$4 %acmillan Pu,lishers4 1K8K<
htt'J::oc(<osa*a-u<ac<8':contents:1K:%E00G12<'d# "or unit 9l A 9ll
htt'J::oc(<osa*a-u<ac<8':contents:1K:%E0021<'d# "or unit 9l
htt'J::oc(<osa*a-u<ac<8':contents:1K:%E00G26<'d# "or unit 9ll
htt'J::oc(<osa*a-u<ac<8':contents:1K:%E00602<'d# "or unit 9l A 9ll
htt'J::(((<,ioin#o<de:is,:gc,01:'oster:hurle,aus<html
3o( (ill ,ioin#ormatics in#luence meta,olic engineeringU !iotechnol !ioeng< 1KK8
-'r 20-%a$ GMG8@2-3BJ162-K< "or unit 9ll
70
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% $ 2
BIOIN1OR#ATICS LAB
1B Demonstration o# !+-S/4 "-S/- and other search engines
2B Clustering and contig assem,l$ tool
3B %ulti'le se?uence alignment and 'h$logenetic anal$sis<
B 0ene #inder @PredictionB
GB 2estriction site anal$sis tools
6B Protein 1isuali7ation tools @2-S%6+B
EKUIP#ENTS0
1< Com'uters
2< &nternet #acilit$
3< !ioin#ormatics so#t(are
71
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DOWNSTREA# PROCESSING LABORATORY
C(ll 823)<7t2o4 t(*+42G<(3.
Solid se'aration methods-#iltration4 sedimentation4 centri#ugation4 'roduct enrichment o'erations4
'reci'itation4 ultra #iltration4 t(o-'hase a?ueous e;traction4 high-resolution 'uri#ication4 're'arati1e li?uid
chromatogra'hic techni?ues4 'roduct cr$stalli7ation and dr$ing<
EG<27:(4t3
1< /angential #lo( #iltration unit
2< Cltra #iltration mem,rane
3< Centri#uge
< Chromatogra'hic matri;
G< Chromatogra'hic columns
6< C9-9is s'ectro'hotometer
7< se'arating #unnels
8< +$o'hili7er
K< %agnetic stirrer
72
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IV Y(a) B.T(*+ BT II-S(: T P C
4,- % 4
ANI#AL CELL SCIENCE AND TECHNOLOGY
U42t I0
Structure and 6rgani7ation o# animal cellM E?ui'ments and materials #or animal cell culture technolog$M
Primar$ and esta,lished cell line culturesM &ntroduction to the ,alanced salt solutions and sim'le gro(th
medium4
U42t II0
!rie# discussion on the chemical4 'h$sical and meta,olic #unctions o# di##erent constituents o# culture
medium< 2ole o# car,on dio;ide< 2ole o# serum and su''lementsM Serum A 'rotein #ree de#ined media and
their a''lication<
U42t III0
%easurement o# 1ia,ilit$ and c$toto;icit$M !iolog$ and characteri7ation o# the cultured cells4 measuring
'arameters o# gro(thM
U42t IV0
!asic techni?ues o# mammalian cell culture in 1itroM disaggregation o# tissue and 'rimar$ culture4
maintenance o# cell cultureM cell se'aration<
U42t V0
Cell s$nchroni7ationM Cell cloning and micromani'ulationM Cell trans#ormationM -''lication o# animal cell
cultureM Scaling-u' o# animal cell culture<
U42t VI0
Stem cell cultures4 em,r$onic stem cells and their a''licationsM Cell culture ,ased 1accines4 Somatic cell
genetics<
U42t VII0
6rgan and histot$'ic culturesM %easurement o# cell deathM -'o'tosisM
U42t VIII0
/hree dimensional culture and tissue engineering<
TE.T BOO/S0
1< Culture o# -nimal Cells4 @3rd EditionB4 "1< &an "roshne$< )ile$-+iss<
2< -nimal Cell Culture = Practical -''roach4 Ed< Eohn 2<)< %asters4 6Y"62D<
RE1ERENCES
1< Cell Culture +a, "a;< Eds< %< !utler A %< Da(son4 !ios Scienti#ic Pu,lications
+td<4 6;#ord<
2< -nimal Cell Culture /echni?ues< Ed< %artin Cl$nes4 S'ringer<
3< %ethods in Cell !iolog$4 9ol< G74 -nimal Cell Culture %ethods< Ed< Eenni P<
%ather and Da1id !arnes< -cademic Press<
< Cell 0ro(th and Di1isionJ - Practical -''roach< Ed< 2< !asega4 &2+ Press<
73
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1OOD SCIENCE E TECHNOLOGY
AEl(*t2>(-IIIB
UNIT - INTRODUCTION TO 1OOD SCIENCE E TECHNOLOGY
"undamentals and -ims o# #ood science and technolog$< &nterdisci'linar$ a''roach4 5utriti1e 1alue o# #oods4
"ood as a source o# energ$4 "ood 3ealth and disease<
UNIT -2 1OOD CHE#ISTRY
"ood chemistr$-de#inition and im'ortance4 (ater in #ood4 (ater acti1it$ and shel# li#e
o# #ood< Car,oh$drates- #unctional 'ro'erties o# sugars and 'ol$saccharides in #oods< +i'idsJ use o# li'ids in
#oods4 'h$sical and chemical 'ro'erties4 e##ects o# 'rocessing on #unctional 'ro'erties and nutriti1e 1alue<
Protein and amino acidsJ 'h$sical and chemical 'ro'erties4 distri,ution4 amount and #unctions o# 'roteins in
#oods4 #unctional 'ro'erties4 e##ect o# 'rocessing<-+osses o# 1itamins and minerals due to 'rocessing<
UNIT -$ 1OOD #ICROBIOLOGY
%icro,ial gro(th 'attern4 /$'es o# micro-organism normall$ associated (ith #ood-mold4 $east4 and ,acteria<
%icro-organisms in natural #ood 'roducts< Contaminants o# #oods-stu##s4 "isheries4 mil* and meat during
handling and 'rocessing< !iochemical changes caused ,$ micro-organisms4 deterioration o# 1arious t$'es o#
#ood 'roduct< "ood 'oisoning and micro,ial to;ins4 standards #or di##erent #oods< "ood ,orne into;icants and
m$coto;ins<
UNIT -4 1OOD P)(3()>at2o4
Princi'les o# #ood 'reser1ationJ Ph$sical 4chemical 4and ,iological methods o# 'reser1ations< !io'rocessing
o# meat4 "isheries4 1egeta,les4 diar$ 'roducts< &rradiated #oods<
UNIT -! 1oo8 B2ot(*+4olo5C
!iotechnolog$ in relation to #ood industr$4 En7$mes in #oods and #ood industr$4 5ature and t$'e o#
starters42ole o# starters in "ermented #oods4 "ermentation o# %il* 'roducts-"ermented so$ and 'eanut mil*4
"ruit and cereal ,ased ,e1erages4 5on ,e1erage 'lant 'roducts< %$co'rotein 'roduction<
UNIT -" 1OOD A882t2>(3 a48 ANALYSIS
Sam'ling techni?ues and theor$ and 'ractice o# chemical and 'h$sical methods o# #ood anal$sis #or
determination o# #ood com'ositionM Pigments in #ood4 #ood #la1ours4 #ood additi1es and to;icants< 5atural
s(eeteners and arti#icial s(eeteners and their role in controlling diseases and de#iciencies4 5utraceuticals4
and "unctional "oods
UNIT -H 1OOD PROCESSING
!asic 'rinci'les4 unit o'erations4 and e?ui'ment in1ol1ed in the commerciall$ im'ortant #ood 'rocessing
methods and unit o'erationsM materials and containers used in #ood 'ac*aging<
UNIT -& 1OOD KUALITY ASSURANCE
6,8ecti1es4 im'ortance and #unctions o# ?ualit$ control< %ethods o# ?ualit$4 assessment o# #ood materials-
#ruits4 1egeta,les4 cereals4 dair$ 'roducts4 meat4 'oultr$< "ood regulations4 grades and standards4 Conce't
o# Code; -lmentarious:3-CCP:CS"D-:&S6 K000 series etc< "ood la(s and standards<
1 Ea$ E<%< 1K86< %odern "ood %icro,iolog$< 3rd Edn< 9524 5e( Dor*<
2 "ood 'rocessing and Preser1ation P3& 'ri1ate ltd45e( Delhi
3 "ood %icro,iolog$ #ourth edition )illiam C<"ra7ier4 /ata %c 0ra( 3ill
"ood %icro,iolog$ 2
nd
Edition4 %ichael P<Do$le 4-S% 'ress
G "ennema4 6<2< Ed< 1K76< Princi'les o# "ood ScienceJ Part-& "ood Chemistr$< %arcel De**er4 5e( Dor*<
6 %e$er4 +<3< 1K73< "ood Chemistr$< East-)est Press P1t< +td<4 5e( Delhi<
7 Charalam,ous4 0< and &nglett4 0< 1K81< /he >ualit$ o# "oods and !e1erages< @2 1ol< setB< -cademic
Press4 5e( Dor*<
8 Frammer4 -< and /(igg4 !<-< 1K70< >ualit$ Control #or the "ood &ndustr$< 3rd Edn< -9&4 )est'ort<
K 2anganna4 S< 1K86< 3and,oo* o# -nal$sis and >ualit$ Control #or "ruits and 9egeta,le Products< /ata
%c0ra( 3ill4 5e( Delhi<
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4,- % 4
#OLECULAR #ODELING AND DRUG DESIGN
AEl(*t2>( IIIB
UNIT I0 INTRODUCTION TO #OLECULAR #ODELLING
&ntroduction to %olecular %odelling< )hat are models used #orU -reas o# a''lication = Single
molecule calculation4 assem,lies o# molecules< 2eaction o# the molecules< Dra(,ac*s o#
mechanical models as com'ared to gra'hical models< Co-ordinate s$stems t(o = matri;4
'otential energ$ sur#ace<
UNIT II ' KUANTU# #ECHANICS
Postulates o# ?uantum mechanics4 electronic structure calculations4 a, initio4 semi-em'irical
and densit$ #unctional theor$ calculations4 molecular si7e 1ersus accurac$< -''ro;imate
molecular or,ital theories<
UNIT III0 E#PIRICAL 1ORCE 1IELD #ODELS
%olecular %echanisms4 energ$ calculations4 !ond stretch4 angle ,ending4 torsional term<
Electrostatic interaction- 9an der (aals interactions< %iscellaneous interaction<
UNIT IV ' #OLECULAR DYNA#ICS
&ntroduction4 %olecular D$namics using sim'le models< D$namics (ith continuous 'otentials<
Constant tem'erature and constant d$namics< Con#ormation searching4 S$stematic search<
-''lications to 'rotein #olding
UNIT V ' CO#PARATIVE PROTEIN #ODELING
%odelling ,$ 3omolog$-the alignment4 construction o# #rame (or* 4selecting 1aria,le regions4
side chain 'lacement and re#inement4 1alidation o# 'rotein models =2amchandran 'lot4
threading and a, initio modeling<
UNIT VI0 ANALOG BASED DRUG DESIGN
&ntroduction to >S-2< lead module4 linear and nonlinear modeled e?uations4 ,iological
acti1ities4 'h$sicochemical 'arameter and molecular descri'tors4 molecular modelling in
drug disco1er$<
UNIT VII0 STRUCTURE BASED DRUG DESIGN
3D 'harmaco'hores 4molecular doc*ing4 De no1o +igand design4 "ree energies and sol1ation4
electrostatic and non-electrostatic contri,ution to #ree energies<
UNIT VIII0 1URTHER APPLICATIONS ON THE DESIGN O1 NEW #OLECULES
3D data ,ase searching and 1irtual screening4 Sources o# data4 molecular similarit$ and
similarit$ searching4 com,inatorial li,raries = generation and utilit$4
TE.TBOO/S
1< Princi'les and a''lications o# modelling ,$ +each
2< %olecular %odelling ,$ 3ans Pieter43elt8e A 0erd "ol*ens4 9C3<
RE1ERENCES0
1< Chemical -''lications o# %olecular %odelling ,$ Eonathan 0oodman<
2< Com'utational Chemistr$ ,$ 0u$ 34 0rant A )< 0raham 2ichards4 6;#ord Cni1ersit$
Press< -'ril 1K8G
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BIOPROCESS ECONO#ICS E PLANT DESIGN
AEl(*t2>( - IIIB
UNIT I0 PROCESS DESIGN DEVELOP#ENT
/echnical #easi,ilit$ sur1e$4 'rocess de1elo'ment4 #lo( diagrams4 e?ui'ment design
and s'eci#ications<
UNIT II0 GENERAL DESIGN CONSIDERATION
%ar*eta,ilit$ o# the 'roduct4 a1aila,ilit$ o# technolog$4 ra( materials4 e?ui'ments4 human resources4 land
and utilities4 site characteristics4 (aste dis'osal4 go1t< regulations and other legal restrictions4 communit$
#actors and other #actors a##ecting in1estment and 'roduction costs<
UNIT III0 COST ESTI#ATION I
Ca'ital in1estments- #i;ed ca'ital in1estments including land4 ,uilding4 e?ui'ments and utilities4 installation
costs @including e?ui'ments4 instrumentation4 'i'ing4 electrical installation and other utilitiesB4 (or*ing ca'ital
in1estments<
UNIT IV0 COST ESTI#ATION II
%anu#acturing costs- Direct Production costs @including ra( materials4 human resources4 maintenance and
re'air4 o'erating su''lies4 'o(er and other utilities4 ro$alties< etc<B4 #i;ed charges @including de'reciation4
ta;es4 insurance4 rental costs etc<B4
UNIT V0 PLANT OVERHEADS
-dministration4 sa#et$ and other au;iliar$ ser1ices4 'a$roll o1erheads4 (arehouse and storage #acilities etc<
UNIT VI0 PRO1ITABILITY ANALYSIS
Pro#ita,ilit$ -nal$sis- return on original in1estment4 interest rate o# return4 accounting #or uncertaint$ and
1ariations and #uture de1elo'ments<
UNIT VII0 OPTI#IJATION
6'timi7ation techni?ues - +inear and D$namic 'rogramming4 6'timi7ation strategies<
UNIT VIII0 PATENTS= IPR AND IPP
Patent conce't and its com'osition and 'rotection o# right and their limitation and &P2 @&ntellectual 'ro'ert$
rightsB< &ntellectual 'ro'ert$ 'rotection<
TE.T BOO/S0
1< Peters and /immerh*us4 Plant design and Economics #or Chemical Engineers4 %c0ra( 3ill th Edition4
1K8K<
2< 2udd and )atson4 Strateg$ o# Process Engineering4 )ile$< 1K87
RE1ERENCE0
1< 0earing C' "or Patents4 /he &ndian Scenario4 Cni1ersities Press !$ 0anguli<
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4,- % 4
BIOPHAR#ACEUTICAL TECHNOLOGY
El(*t2>(-IV
UNIT I0 INTRODUCTION TO PHAR#ACEUTICALS
3istor$ A De#inition o# Drugs< Sources o# Drugs - Plant4 -nimals4 %icro,es and %inerals< Di##erent dosage
#orms< 2outes o# drug administration<
UNIT II0 PHAR#ACODYNA#ICS
Ph$sico-Chemical Princi'les4 Pharmacod$namics- %echanism o# drug action4 drug rece'tors4 and
Ph$siological rece'torsJ structural and #unctional #amilies<
UNIT III0 PHAR#ACO/INETICS
Pharmaco*inetics- Drug a,sortion4 #actors that a##ect the a,sortion o# drugs4 Distri,ution o# drugs4
!iotrans#ormation o# drugs4 !ioa1aila,ilit$ o# drugs<
UNIT IV0 DRUG #ANU1ACTURING PROCESSES I
0ood manu#acturing 'ractices4 manu#acturing #acilities4 sources o# !io'harmaceuticals4
UNIT V0 DRUG #ANU1ACTURING PROCESSES II
Production A anal$sis o# !io'harmaceuticals<
UNIT VI0 PRODUCTION O1 BIOPHAR#ACEUTICALS
Production o# /hera'eutic Proteins4 3ormones4 C$to*ines - &nter#erons4 &nterleu*ins & A &&4 /umor 5ecrosis
"actor @/5"BM 5ucleic acids<
UNIT VII0 APPLICATIONS O1 BIOPHAR#ACEUTICALS
2ole o# !io'harmaceuticals in treatment o# 1arious health disorders
UNIT VIII0 DRUG DELIVERY SYSTE#S= BIO#ATERIALS AND THEIR APPLICATIONS
Controlled and sustained deli1er$ o# drugs< !iomaterial #or the sustained drug deli1er$< +i'osome mediated
drug deli1er$< Drug deli1er$ methods #or thera'eutic 'roteins<
R(9()(4*(0
1< !io'harmaceuticalsJ !iochemistr$ A !iotechnolog$4 0ar$ )alsh @1KK8B4 Eohn )ile$ A
Sons +td<
2< 2emingtonHs Pharmaceutical sciences4 @%ar* Pu,lications A Com'an$ eston P- B $ear 1K80<
3< /heor$ A Practice o# &ndustrial Pharmac$4 @3rd ed<B +eon +achman4 +ea A
"e,iger @1K86B
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PHYTOCHE#ICALS AND HERBAL #EDICINE
AELECTIVE ' IVB
UNIT I0 CRUDE DRUGS
Crude Drugs = Sco'e A &m'ortance4 Classi#ication @/a;onomical4 %or'hological Chemical4
PharmacologicalBM Culti1ation4 Collection A 'rocessing o# Crude Drugs<
UNIT II0 #EDICINAL E ARO#ATIC PLANTS
Culti1ation and Ctili7ation o# %edicinal A -romatic Plants in &ndia< 0enetics as a''lied to %edicinal her,s<
UNIT III0 TISSUE CULTURE O1 #EDICINAL PLANTS
Plant /issue Culture as source o# medicines4 Plant /issue Culture #or enhancing secondar$ meta,olite
'roduction @)ithania somni#era4 2au(ol#ia ser'entina4 Catheranthus roseus4 -ndrogra'his 'aniculata4
Dioscorea s'<BM -nticancer drugs4 !iogenesis o#
Ph$to'harmaceuticals<
UNIT IV0 ANALYSIS O1 PHYTOCHE#ICALS
%ethods o# Drug e1aluation @%or'hological4 %icrosco'ic4 Ph$sical A ChemicalB< Preliminar$ screening4
-ssa$ o# Drugs = !iological e1aluation : assa$s4 %icro,iological methods
U42t V0 C+(:2*al #(t+o83 o9 A4alC323 a48 D(t(*t2o4 o9 A8<lt()a4t30 Chemical estimations4
S'ectro'hotometr$ A "luorescene anal$sis< Drug adulteration = /$'es o# adulterants<
UNIT VI0 TYPES O1 PHYTOCHE#ICALS_I
Car,oh$drates A deri1ed 'roductsM 0l$cosides - e;traction methods @Digitalis4 -loe4 Dioscorea4BM /annins
@3$drol$sa,le A Condensed t$'esBM 9olatile 6ils - e;traction methods
@Clo1e4 %enthaBM
UNIT VII 0 TYPES O1 PHYTOCHE#ICALS_II
-l*aloids - e;traction methods @/a;us4 Pa'a1er4 CinchonaBM "la1onoids- e;traction methods4 2esins-
e;traction methods<
UNIT VIII0 APPLICATIONS O1 PHYTOCHE#ICALS
-''lication o# 'h$tochemicals in industr$and healthcareM !iocides4 !io#ungicides4 !io'esticides<
T(@t Boo630
1< Pharmacognos$4 C< F< Fo*ate4 -< P< Purohit A S< !< 0o*hale @1KK6B4 5irali Pra*ashan4 th Ed<
2< 5atural Products in medicineJ - !ios$nthetic a''roach @1KK7B4 )ile$<
R(9()(4*(3
1< 3orno*4+< @ed<B @1KK2B< Culti1ation A Processing o# %edicinal Plants4 Chichister4 C< FJ
E< )ile$ A Sons<
2< /rease A E1ans4 Pharmacognos$ = )illiam Charles E1ans4 1th ed< @1K8KB4 3arcourt
!race A Com'an$<
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BIOPROCESS OPTI#IJATION
AEl(*t2>( IVB
UNIT I0 BASIC CONCEPT
61er1ie( o# e;'erimental design in ,iological 'rocesses4 understanding o# 1aria,les in ,iological 'rocesses<
UNIT II0 OPTI#IJATION APPROACHES
5on-statistical4 statistical and numerical o'timi7ation-#undamental theor$<
UNIT III0 STATISTICAL OPTI#IJATION
"irst order and second order designs4 di##erences in a''roaches4 general res'onse sur#ace anal$sis<
UNIT IV0 1IRST ORDER DESIGNS
Statistical e;'erimental 'rocedures #or 'lc*ett-,urman taguchiHs designs<
CNIT V0 DETER#INATION O1 OPTI#AL CONDITIONS
%ethod o# 2idge anal$sis4 5elder-%ead sim'le; method4 o'timi7ation o# multi res'onse ,iological s$stems<
UNIT VI0 #I.TURE DESIGNS AND ANALYSIS
Sim'le4 latis arrangement and their associated models<
UNIT VII0 VARIANCE AND DESIGN
9ariance minimi7ing design4 mi;ed 1aria,le and multi res'onse generali7ed distance #unction a''roaches
#or multires'onse o'timi7ation<
UNIT VIII0 NON-STATISTICAL OPTI#IJATION AND E.A#PLES
Sel# =directing o'timi7ation4 case studies (ith single res'onse and multi res'onse anal$sis<
!66FS
1<!<1oles*$ and E<1otru,a4%odelling o'timi7ation o# #ermentation 'rocesses4Else1ier4-msterdam41KK2<
2<-<&<Fhruri and E<-<Cornell42es'onse sur#ace = design and o'timi7ation45e($or*41K87<
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INDUSTRY ORIENTED #INI PROJECT
80
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SE#INAR
81
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PROJECT WOR/
82
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CO#PREHENSIVE VIVA
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2007-2008

JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY

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