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  • Drug Examples of Usual Doses Toxicity Interactions, Issues Direct DNA-Interacting Agents Alkylators

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    The document lists several examples of common drugs used as direct DNA-interacting agents for their usual doses, toxicity risks, and important drug interactions or issues. Some of the alkylating agents mentioned include cyclophosphamide, mechlorethamine, chlorambucil, and melphalan, which can cause bone marrow suppression and other toxicities. Iphosphamide is also reviewed as an isomeric analogue of cyclophosphamide that requires co-administration with mesna to reduce bladder toxicity risks.

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    chemo

    Original Title

    Alkylating Agents

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    The document lists several examples of common drugs used as direct DNA-interacting agents for their usual doses, toxicity risks, and important drug interactions or issues. Some of the alkylating agents mentioned include cyclophosphamide, mechlorethamine, chlorambucil, and melphalan, which can cause bone marrow suppression and other toxicities. Iphosphamide is also reviewed as an isomeric analogue of cyclophosphamide that requires co-administration with mesna to reduce bladder toxicity risks.

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    17 views1 page

    Drug Examples of Usual Doses Toxicity Interactions, Issues Direct DNA-Interacting Agents Alkylators

    Uploaded by

    docbin
    The document lists several examples of common drugs used as direct DNA-interacting agents for their usual doses, toxicity risks, and important drug interactions or issues. Some of the alkylating agents mentioned include cyclophosphamide, mechlorethamine, chlorambucil, and melphalan, which can cause bone marrow suppression and other toxicities. Iphosphamide is also reviewed as an isomeric analogue of cyclophosphamide that requires co-administration with mesna to reduce bladder toxicity risks.

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    © All Rights Reserved
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    of 1

    Drug Examples of

    Usual Doses
    Toxicity Interactions, Issues
    Direct DNA-Interacting Agents
    Alkylators
    Cyclophosphamide 4002000
    mg/m
    2
    IV
    100 mg/m
    2
    PO
    qd
    Marrow (relatie
    platelet spari!g"
    Cystitis
    Commo! al#ylator
    a
    Cardiac (high dose"
    $ier meta%olism req&ired to
    actiate to phosphoramide m&stard
    ' acrolei!
    Mes!a protects agai!st (high)
    dose( %ladder damage
    Mechlorethami!e * mg/m
    2
    IV day
    1 a!d day +

    Marrow
    Vesica!t
    ,a&sea
    -opical &se i! c&ta!eo&s
    lymphoma
    Chloram%&cil 1. mg/m
    2
    qd
    PO

    Marrow
    Commo! al#ylator
    a

    Melphala! + mg/m
    2
    qd / 01
    PO

    Marrow (delayed
    !adir"
    2I (high dose"
    3ecreased re!al 4&!ctio! delays
    cleara!ce
    Carm&sti!e
    (5C,6"
    200 mg/m
    2
    IV
    100 mg/m
    2
    PO
    Marrow (delayed
    !adir"
    2I1 lier (high dose"
    7e!al

    $om&sti!e (CC,6" 100.00 mg/m
    2

    PO

    Marrow (delayed
    !adir"

    I4os4amide 182 g/m
    2
    per day
    qd / 0 ' mes!a

    Myelos&ppressie
    5ladder
    ,e&rologic
    Meta%olic acidosis
    ,e&ropathy
    Isomeric a!alog&e o4
    cyclophosphamide
    More lipid sol&%le
    2reater actiity s testic&lar
    !eoplasms a!d sarcomas
    M&st &se mes!a

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