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  • Drug Examples of Usual Doses Toxicity Interactions, Issues Direct DNA-Interacting Agents Alkylators

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    This document provides examples of usual drug doses, toxicity, and interactions for several direct DNA-interacting agents including alkylators. Some key drugs discussed include cyclophosphamide, which is commonly used at doses of 400-2000 mg/m2 IV or 100 mg/m2 orally daily and can cause marrow toxicity and cystitis. Melphalan is another alkylating agent usually given at 2-6 mg/m2 orally daily or weekly and can cause marrow toxicity with delayed nadirs. Carmustine has a usual dose of 200 mg/m2 IV or 100 mg/m2 orally and can lead to marrow toxicity with delayed nadirs at higher doses as well as renal toxicity.

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    chemo

    Original Title

    Alkylating Agents

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    This document provides examples of usual drug doses, toxicity, and interactions for several direct DNA-interacting agents including alkylators. Some key drugs discussed include cyclophosphamide, which is commonly used at doses of 400-2000 mg/m2 IV or 100 mg/m2 orally daily and can cause marrow toxicity and cystitis. Melphalan is another alkylating agent usually given at 2-6 mg/m2 orally daily or weekly and can cause marrow toxicity with delayed nadirs. Carmustine has a usual dose of 200 mg/m2 IV or 100 mg/m2 orally and can lead to marrow toxicity with delayed nadirs at higher doses as well as renal toxicity.

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    18 views1 page

    Drug Examples of Usual Doses Toxicity Interactions, Issues Direct DNA-Interacting Agents Alkylators

    Uploaded by

    docbin
    This document provides examples of usual drug doses, toxicity, and interactions for several direct DNA-interacting agents including alkylators. Some key drugs discussed include cyclophosphamide, which is commonly used at doses of 400-2000 mg/m2 IV or 100 mg/m2 orally daily and can cause marrow toxicity and cystitis. Melphalan is another alkylating agent usually given at 2-6 mg/m2 orally daily or weekly and can cause marrow toxicity with delayed nadirs. Carmustine has a usual dose of 200 mg/m2 IV or 100 mg/m2 orally and can lead to marrow toxicity with delayed nadirs at higher doses as well as renal toxicity.

    Copyright:

    © All Rights Reserved
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    Drug Examples of

    Usual Doses
    Toxicity Interactions, Issues
    Direct DNA-Interacting Agents
    Alkylators
    Cyclophosphamide 4002000 mg/m
    2
    IV
    100 mg/m
    2
    PO
    qd
    Marrow (relatie
    platelet spari!g"
    Cystitis
    Commo!
    al#ylator
    a
    Cardiac (high
    dose"
    $ier meta%olism req&ired to actiate
    to phosphoramide m&stard ' acrolei!
    Mes!a protects agai!st (high)dose(
    %ladder damage
    Mechlorethami!e * mg/m
    2
    IV day
    1 a!d day +

    Marrow
    Vesica!t
    ,a&sea
    -opical &se i! c&ta!eo&s lymphoma
    Chloram%&cil 1. mg/m
    2
    qd
    PO

    Marrow
    Commo!
    al#ylator
    a

    Melphala! + mg/m
    2
    qd / 01
    PO

    Marrow (delayed
    !adir"
    2I (high dose"
    3ecreased re!al 4&!ctio! delays
    cleara!ce
    Carm&sti!e
    (5C,6"
    200 mg/m
    2
    IV
    100 mg/m
    2
    PO
    Marrow (delayed
    !adir"
    2I1 lier (high
    dose"
    7e!al

    $om&sti!e (CC,6" 100.00 mg/m
    2

    PO

    Marrow (delayed
    !adir"

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