1.

2.
FDA

(1,2)

1.
2.

Methylprednizolone
perostaperingmethylprednisolone

Interferonbeta1 a(30mcg)()
Interferonbeta1 a(22mcg44mcg)(
)
Interferonbeta1 (250microg(8MIU))(

x)
glatirameracetate(20mg)()

Interferon beta1 a(44mcg)( )

Interferonbeta1 (250microg(8MIU))(
x)

mitoxantrone(

:140mg/m)

(3)
(

MRI)

Natalizumab300mg()

Peros

Fingolimod0.5mg/24

mitoxantrone(
:140mg/m)

(4)

(1,2)

Interferonbeta1 a(30mcg)()
Interferonbeta1 a(44mcg)(
)
Interferonbeta1 (250microg(8MIU))(
x)
glatirameracetate(20mg)()

McDonald(Polmanetal)

2
2

2
1
1
2

1
1
()

( )

.(
)
MRIMRI
,
MRI

MRIMRI
MRI
()
: )MRI(22
VEP)
)MRI (2)

2
:
MRI(Barkhof)
34:
192

1
1
3
:1

:
IgG()
IgGindex

3
Natalizumab,Fingolimod

(
).
1
,9T2
1Gd
.

,.

,2
,1Gd

T2
.

4
:,
(CIS)

,

,
,

MRI

FD

FDA,

FDA,
,.

1.
1.Azathioprine2mg/kgperos
2.Methotrexate7.5mgperos
3.Mycophenolatemofetil2000mgperos
4.CyclosporineA5mg/kg/peros
5.Cyclophosphamide400500mg5
6.Rituximab:21000mg1and15
.:2
1000mg24and26and26),72

2.
01502g/kg
24

()(DEVIC)

1.

2.
1.Methotrexate7.5mgperos
2.Mycophenolatemofetil2000mgperos
3.Rituximab:21000mg1and
15.:2
1000mg24and26and26),72

3.
01502g/kg