PATHOPHYSIOLOGY OF MENIERES DISEASE

Etiology:
IDIOPATHIC
Predisposing Factors:
AUTOIMMUNITY
GENETIC
SUSCEPTIBILITY

Precipitating Factors:
ALLERGY
METABOLIC
DISTURBANCES
VIRAL ILLNESS

Increase in endolymphatic pressure
Physical Distention

Mechanical
Disturbance of the
Organ of Corti

Distortion of the
Basilar membrane,
inner and outer hair
cells

Tinnitus

Distortion of the
Cochlea (Apex part)

Low frequency
Hearing Loss

Breakage in Reissners
membrane

Mixture of Perilymph and
Endolymph

Bathe the vestibular
nerve receptors

Repolarization blockade

Change in the rate of
vestibular nerve firing

Vertigo

Tx:
Caroverine

Tx:
Hearing Aid

Tx:
Meclizine
Prochlorperazine
Gentamicin
Diazepam

Tx:
Diuretic (Water Pill)
Betahistine
Dexamethasone

Surgery:
Labyrinthectomy

Surgery:
Vestibular nerve
section

Inflammation Increase production and Decrease
excretion of endolymph