Scribd Logo
Upload

Welcome to Scribd!

  • Calcularea Target-Limits Labquality

    Uploaded by

    f.baxy
    24 views23 pages
    The document discusses target limits for external quality assessment (EQA) schemes and how they are determined. It explains that target limits are set as the target value plus or minus the total error, which includes imprecision and bias. Target limits can be based on clinical needs, state of the art methods, biological variation, and statistical methods. The document provides examples of quality specifications and target limits used in Labquality clinical chemistry surveys. It notes that Labquality's target limits are educational and not administrative, and are generally quite tight.

    Original Description:

    target-limits

    Original Title

    Calcularea Target-limits Labquality

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The document discusses target limits for external quality assessment (EQA) schemes and how they are determined. It explains that target limits are set as the target value plus or minus the total error, which includes imprecision and bias. Target limits can be based on clinical needs, state of the art methods, biological variation, and statistical methods. The document provides examples of quality specifications and target limits used in Labquality clinical chemistry surveys. It notes that Labquality's target limits are educational and not administrative, and are generally quite tight.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    24 views23 pages

    Calcularea Target-Limits Labquality

    Uploaded by

    f.baxy
    The document discusses target limits for external quality assessment (EQA) schemes and how they are determined. It explains that target limits are set as the target value plus or minus the total error, which includes imprecision and bias. Target limits can be based on clinical needs, state of the art methods, biological variation, and statistical methods. The document provides examples of quality specifications and target limits used in Labquality clinical chemistry surveys. It notes that Labquality's target limits are educational and not administrative, and are generally quite tight.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 23

    LABQUALITY

    Om Analytisk Imprecision
    och
    Analysers Totalfel
    Vrmte
    Lule 250505
    Teddy Weber
    LABQUALITY
    Do the current target limits of EQA
    schemes serve participants well enough?
    interpretation of results
    conclusions on analytical
    performance
    LABQUALITY
    Target limits
    = target value total error
    imprecision
    bias
    method group mean
    or
    reference method value
    LABQUALITY
    - clinical needs
    - state of the art
    - statistical methods
    - within- and between-subject biological
    variation
    - suitable part of reference intervals
    Different considerations can lead to different
    target limits.
    The priority may be maximal allowable error or
    educational quality goals.
    Approaches for defining permissible total error
    LABQUALITY
    imprecision
    less than a half of the within-subject biological variation
    bias
    less than of the biological variation (within + between-
    subject variation)
    or
    less than 1/16 of the reference interval
    Biological variation
    Common reference intervals
    Components of total error are based on
    LABQUALITY
    Target value (bias + 1.65 * imprecision)
    Target value ( CV
    bt
    + 1.65 * CV
    bw
    )
    bt = total biological variation
    bw= within-subject biol.variation
    The target limits are set so that when the methods are
    performing correctly, the result will be within the target limits
    with 95% probability
    LABQUALITY
    sometimes
    biological variation approach would lead to too
    demanding analytical goals (e.g. Na total error
    0.9%)
    total error 2%
    CV%-target from the analytical performance
    LABQUALITY
    sometimes
    biological variation approach would lead to too wide
    analytical goals (enzymes e.g. CK 27%, ALT 36%)
    CV%-target for enzymes from the analytical
    performance
    total error 12%
    LABQUALITY
    Examples of Quality specifications in
    Labquality clinical chemistry surveys
    Albumin 5 % Ca-Ion 3 % CRP 15 %
    ALP 12 % Cholesterol 5 % Free T4 12 %
    ALT 12 % Chol-HDL 10 % Sodium 2 %
    Bilirubin 12 % CK 12 % Triglyserides 15 %
    Calcium 3 % Creatinine 8 % TSH 12 %
    LABQUALITY
    Labqualitys target limits are educational
    and not administrative.
    Labqualitys target limits are quite tight.
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY
    LABQUALITY

    You might also like