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Canine and Feline Nasal Neoplasia
Canine and Feline Nasal Neoplasia
Dogs
Nasal Carcinoma
Incidence and Clinical Signs
Carcinomas, including adenocarcinoma, squamous cell carcinoma, and undifferentiated carcinoma, comprise twothirds of intranasal cancer in dogs.1 The average age of patients with this form of cancer is 10 years, and a slight
predilection exists for male dogs.1 Medium- to large-breed
dogs seem to also be at a greater risk.1
The most common clinical signs secondary to intranasal
carcinoma are epistaxis, mucopurulent nasal discharge, facial
deformity, and occasionally epiphora.1,2 Potential differential
diagnoses for dogs with these clinical signs include systemic
hypertension, fungal or bacterial infections, and developmental anomalies.1 However, a strong presumptive diagnosis
of intranasal neoplasia can be formed for an older dog who
presents with a history of intermittent and progressive, unilateral epistaxis or nasal discharge.1 Certain dogs may present
Michigan State University, Department of Small Animal Clinical Sciences,
Lansing, MI.
Address reprint requests to: Dr. Christine Malinowski, Michigan State University, Department of Small Animal Clinical Sciences, 2016 Clifton
Avenue, Lansing, MI 48910. E-mail: cmmalinowski@michvet.com.
with concurrent neurologic deficits as well, which is consistent with extension of the cancer into the central nervous
system.1
Staging and Diagnosis
A definitive diagnosis of intranasal cancer requires evaluation
of a tissue biopsy. Before a biopsy procedure, a complete
work-up should be performed to rule out other forms of
systemic disease. A complete physical examination including
an ocular examination should be completed looking for evidence of retinal hemorrhage or tortuous retinal vessels. Accurate systemic blood pressure should be assessed along with
a complete blood count (CBC), serum biochemistry profile,
urinalysis, and clotting profile (PT/PTT or ACT).1
If these diagnostic tests are otherwise normal, three-view
thoracic radiographs should be completed and possibly skull
radiographs to assess the nasal cavity.1 The most beneficial of
the skull radiographs is commonly the open-mouth DV view
performed under anesthesia.1 In capturing this view, the exposure film is placed inside the mouth of the patient and
exposed in the DV plane. This view allows initial evaluation
of the nasal turbinates for extent of disease and for detection
of asymmetrical turbinate destruction.1 Other beneficial
views include the following: lateral, dorsoventral (entire
skull), ventro 15 rostral-dorsocaudal oblique, dorso 60
right-ventral left oblique, and dorso 60 left-ventral right
oblique.1,3 Thoracic radiographs are most often normal at the
time of diagnosis.1
Skull radiographs have an additional benefit in that they
offer direction as to where the most beneficial biopsy site
should be. A soft-tissue opacity superimposed over an area of
turbinate destruction in the caudal half of the nose most often
indicates nasal neoplasia.1 Nevertheless, the benefits of skull
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tential to be an important imaging modality for intranasal
cancer, as well. However, at this time, its limited availability
in veterinary medicine limits its practicality.
While the patient is still under anesthesia from its imaging
procedures, rhinoscopy can be used to visualize the tumor
before a biopsy procedure. Although tissue samples are relatively easy to obtain through most endoscopes, this method is
not a recommended sampling procedure. Samples from endoscopically introduced forceps are generally limited to the
superficial layer of tissue due to the small size of the instrument.1,2 The superficial layer of most nasal neoplasms consists of septic inflammation and does not yield a diagnostic
sample of the tumor itself.1,2 Therefore, rhinoscopy should be
utilized as a visual tool only, and a nasal biopsy should be
collected using a closed nasal biopsy technique: a closed
suction technique, a bone curette, or alligator forceps.1
With the closed suction technique, a large-bore (3 to 5
mm) plastic cannula is directed into the nasal cavity and the
tumor while the patient is under anesthesia.1 Negative pressure is applied as the cannula is redirected at multiple angles.1 Care should be taken during any biopsy procedure not
to advance the biopsy tool beyond the level of the medial
canthus of the eye to prevent entering the cribriform plate
and the brain.1,2 This precaution can be taken by premeasuring the tool from the naris to the medial canthus and placing
a mark on the instrument. Mild-to-moderate hemorrhage is a
secondary complication of this and other biopsy procedures
and should be avoided in any patient for which there are
concerns about coagulopathies or high risk for anesthesia.2
Cytological analysis can be facilitated by using a small
cylindrical brush that is introduced into the nasal cavity via
endoscope and then brushed against the lesion.2 This procedure is less invasive than the previously mentioned biopsy
techniques, but again requires an anesthetic event. Unfortunately, the brush technique also has a higher likelihood of
being nondiagnostic as compared with evaluation of a biopsy
or an impression smear from a biopsy sample.1,2,5 More specifically, brush cytology can fail to reveal malignancy versus
benign disease in specimens with low cellularity.2,5 Research
examining the reliability of brush cytology found that the
most accurate results came from cell-rich samples.5 In the
case of a low cell harvest, the procedure should be repeated
or a histological biopsy recommended.2,5 Nasal flushing and
swabbing are additional although generally unreliable cytologic techniques and should not be used as a sole means of
diagnosis.1,5
Nasal carcinomas are locally aggressive tumors, as is demonstrated by their ability to extend through the cribriform
plate into the brain.1 Any patient with central nervous system
signs should have a sample of cerebrospinal fluid collected
and evaluated. Increased protein or cellularity is suggestive of
brain involvement.1 Although these tumors are rarely metastatic, local lymph node aspiration is diagnostic in about 10%
of patients with nasal carcinoma.1
Treatment
Treatment of nasal neoplasia is focused on local control in a
critical location, being adjacent to the brain and eyes.1 Clinical signs are not usually observed and a diagnosis is not
usually made until the tumor is advanced. Although surgery
alone has been attempted, it is rarely curative.1,3 Rhinotomy
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Nasal Sarcoma
Incidence and Clinical Signs
Sarcomas, including fibrosarcoma, chondrosarcoma, osteosarcoma, and undifferentiated sarcoma, comprise the remainder of common intranasal tumors in dogs.1 The average
age of patients with this form of cancer is again about 10
years; however, chondrosarcoma has been shown to occur
commonly in young dogs.1 Medium- to large-breed dogs
seem to be at a greater risk as well.1
The most common clinical signs occurring secondary to
intranasal sarcoma are epistaxis, mucopurulent nasal discharge, facial deformity, and occasionally epiphora1 (Fig. 2A
and B). The differential diagnoses for intranasal neoplasia
were listed in the Incidence and Clinical Signs of nasal
C. Malinowski
92
racic radiographs and imaging of the nasal tumor should be
completed.1 As with nasal carcinomas, thoracic radiographs
are often within normal limits at the time of diagnosis.1 CT is
the ideal diagnostic tool available to assess for the extent of
disease and the degree of bony involvement, but skull radiographs can be very beneficial in directing a biopsy procedure.1
A definitive diagnosis of intranasal cancer requires evaluation of a tissue biopsy. Rhinoscopy and endoscopic biopsy
instruments are limited in their function as it relates to nasal
sarcomas as well as nasal carcinomas. A nasal biopsy should
be collected using a closed nasal biopsy technique.1 Mild-tomoderate hemorrhage should be expected; therefore, a biopsy procedure should be avoided in any patient for which
there are concerns about coagulopathies or high risk for anesthesia.2 Special attention should be given during any biopsy procedure not to advance the biopsy tool beyond the
level of the medial canthus of the eye to prevent entering the
cribriform plate and the brain.1,2
Local lymph node aspiration has had a limited amount of
success in detecting nasal sarcomas as these tumors are rarely
metastatic.1 Fluid analysis, nasal washing, and brush cytology have a high likelihood of being nondiagnostic when mesenchymal tumors are present as compared with evaluation of
a biopsy.1,2 These methods can fail to reveal malignancy versus benign disease.2
Treatment
Treatment of nasal sarcomas is focused on local control.1 As is
the case with nasal carcinoma, patient survival times are not
significantly different if surgery is performed or if no treatment is offered. Bone invasion occurs early, and although
surgery alone has been attempted, it is rarely curative and has
a high level of acute and chronic morbidity.1 The mean survival time is 3 to 6 months due to progression of local disease.1
Radiation therapy is the most effective treatment available
at this time.1,6 Used either alone or in combination with rhinotomy, survival times are increased to between 8 and 25
months depending on the treatment protocol followed.1,6
Nasal sarcoma has been treated with orthovoltage, high-energy megavoltage, and Cobalt radiation alone and in combination as was discussed for nasal carcinoma.1,6 During and
after the completion of these protocols, acute phase side effects of radiation on the mucosal surfaces and eyes were often
noted.1,6
Even if dogs have a resolution of clinical signs, few dogs are
considered cured if followed to necropsy.1 Despite the relatively nonmetastatic nature of nasal sarcoma in untreated
animals, metastatic lesions were found beyond the local site
in 40% of 285 cases given radiation therapy and followed to
necropsy.1 Most metastatic lesions were found in the lymph
node or lungs of those dogs and believed to be due to their
prolonged survival times.1 As more improvements in longterm survival are achieved, the true metastatic potential of
nasal neoplasia may be revealed.1 Chemotherapeutic agents,
especially platinum agents, seem to be effective adjunctive
treatments improving survival times when used as radiation
sensitizers.1
Overall, nasal sarcomas have a better long-term prognosis
Cats
Nasopharyngeal Polyps
Incidence and Clinical Signs
Nasopharyngeal polyps typically occur in cats less than 2
years of age. In one study, greater than 80% of affected cats
were less than 1 year of age.2 The most common clinical signs
were sneezing, snuffling, and upper airway stridor.1,2 Less
commonly, aural or nasal discharge was noted. This disease
of cats is less likely to be of neoplastic origin and more likely
of primary or secondary inflammatory origin.1 The polyps
generally arise from the mucosa of the tympanic bullae or
eustachian tube. The pedunculated mass then extends into
the oral cavity or external ear canal.1 Additional clinical signs
to note include head tilt, circling, and possible nystagmus.2
Staging and Diagnosis
Staging includes a minimum database of a CBC, serum biochemistry profile, urinalysis, FeLV/FIV serology, T4 testing,
and three-view thoracic radiographs. In addition, skull radiographs can assess for soft-tissue opacities within the tympanic bullae, indicating fluid or mass extension into the area.1
Open-mouth radiographs to assess each of the bullae are
recommended, but can give equivocal information. CT scan
of the skull would reveal the full extent of the mass.2
Treatment
Involvement of the bulla is an indication for treatment.2 In
that situation, bulla osteotomy with concurrent appropriate
sampling of the contents for bacteriologic culture and sensitivity should be performed. The patient should then be
treated appropriately in coordination with the results. The
owner should be warned about the likely development of
Horners syndrome postoperatively, which is likely a transient complication that resolves within a month of surgery.2
If involvement of the bulla is not noted, removal should be
sought by excision, including as much of the pedicle as possible or by placing traction on the mass leading to rupture of
the pedicle.2 Recurrence was noted after surgical removal in
about 20% of cases according to one study and can occur
anywhere from 1 month to 3 years after surgery.2 Regrowth
can occur multiple times.
Nasal Carcinomas
Although tumors of the nasal planum, especially squamous
cell carcinoma (SCC), should be considered when evaluating
a patient with facial deformity, sneezing, or upper airway
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patient for which there are concerns about coagulopathies or
high risk for anesthesia.2
Although metastases are uncommon, fine-needle aspiration of an enlarged local lymph node can give valuable cytologic information in combination with cytology or histopathology performed on the gross mass.1,2 Brush cytology is a
fairly noninvasive procedure that can be used in cats to provide valuable information. Caution should be used when
interpreting results as is described in Staging and Diagnosis
of canine nasal carcinomas.2,5
Treatment
Cats have a poor tolerance for rhinotomy.1 Surgery alone for
nasal carcinoma has been reported in a small number of cats
and was correlated with relatively fast tumor recurrence (1 to
12 weeks).2 When surgery was combined with orthovoltage
radiation therapy in six cats with nasal carcinoma, the results
were much improved.2 No recurrence was noted in four of
the cats, two of which died 5 months after therapy of unrelated causes and two of which remained disease-free at 26
and 40 months after therapy.2 Recurrence was noted in the
other two cats 21 and 62 months after therapy.2 Treatment
with surgery and Cobalt-60 irradiation has had less success
with tumor recurrence within 1 year of treatment for each of
three cats.2
Cats treated with Cobalt-60, orthovoltage, or megavoltage
alone experienced moderate success, but all had either local
tumor regrowth or distant metastasis (local lymph node or
lungs) within 11 months of treatment.2 The acute side effects
of radiation therapy were mild overall.2 The degree of moist
desquamation and ocular effects were less than those noted
in similarly treated dogs.2 These relatively mild side effects
could be a sign that cats may be tolerant of larger doses of
radiation.2 Their higher tolerance for radiation therapy may
prove beneficial and should be examined in future reports.
Multiple chemotherapeutic agents including mitoxantrone, carboplatin, cyclophosphamide, and vincristine
have been used without surgery.2 Unfortunately, the latter
two drugs did not cause any noticeable remission.2 Carboplatin appears to be the most promising option for chemotherapeutic treatment of feline nasal carcinoma.
Finally, supportive care is an important treatment that
should not be overlooked. Affected cats will have a reduced
ability to smell and should be treated with appetite stimulants and have their food heated to entice them to eat.1 If oral
nutrition is not of an adequate amount, placement of an
enteral feeding tube should be considered if therapy is likely
to be prolonged.2 In addition, topical eye care will be necessary on a short-term and possibly long-term basis in conjunction with radiation therapy.2
Nasal Sarcomas
Limited reports of intranasal sarcomas have described intranasal fibrosarcoma, chondrosarcoma, osteosarcoma, hemangiosarcoma, and undifferentiated sarcoma.2 Two cats with
chondrosarcoma were treated with surgery alone and both
experienced regrowth of the tumor 6 months later.2 An intranasal osteosarcoma was also treated with surgery alone
twice over a 14-week period and was insufficient to control
tumor growth.2 Six cats with nasal fibrosarcoma or an undifferentiated form of sarcoma were treated with radiation therapy alone and had good results similar to cats with nasal
C. Malinowski
94
carcinoma.2 The median survival for this group was 10
months.2 As can be speculated for cats with nasal carcinoma,
cats with nasal sarcoma that are to be treated with radiation
therapy alone may be able to be treated with larger doses of
radiation than those previously used.2
Olfactory Neuroblastoma
Also referred to as sympathicoblastoma and esthesioneuroblastoma, olfactory neuroblastoma appears to be induced by
the feline leukemia virus (FeLV).2 The most common clinical
signs in addition to nasal discharge and sneezing are CNS
signs including circling, ataxia, behavior changes, and paresis.2 This tumor originates from the neuroectoderm and the
clinical signs appear to stem from the extension of the tumor
into the CNS.8 Support for the role of FeLV in the induction
of this neoplasm is in the presence of FeLV DNA in the tumor
of CNS affected cats correlated with its absence in normal
brain tissue of the same cats.2 As opposed to other intranasal
neoplasia, this tumor is highly metastatic. Initial treatment
with radiation therapy appears to be the most effective, but
early recurrence is expected.2 Follow-up treatment with chemotherapeutics, doxorubicin and carboplatin, may be effective, but is often complicated by the concurrent FeLV infection.2 Prognosis is generally poor.
Nasal Lymphoma
Incidence and Clinical Signs
Nasal lymphoma is the most common cause of nasopharyngeal disease in cats.2 The median age of affected cats among
60 case reports was 8 years old, but ranged from 2 to 19
years.2 Clinical signs vary in duration and are similar to those
reported for other forms of nasal neoplasia in cats: nasal
discharge, dyspnea, epistaxis, stertor, facial deformity, and
anorexia.2,9
Staging and Diagnosis
A minimum database including a CBC, serum biochemistry
profile, urinalysis, FeLV/FIV serology, T4 testing, and threeview thoracic radiographs should be collected along with an
abdominal ultrasound, nasal CT or MRI, and bone marrow
aspiration.1,2 Most affected cats do not have a concurrent
FeLV infection; however, those who are FeLV-positive have a
higher risk of developing systemic disease.2
Brush cytology was used in the previously mentioned reports to correctly identify nasal lymphoma in five of six cats.2
Rhinotomy or nasal biopsy, as described for feline nasal carcinoma, may still be needed to obtain an accurate diagnosis.2
Treatment
In cats without systemic involvement, radiation therapy can
be curative.2 Radiation therapy and chemotherapeutics have
been used alone and in combination to successfully treat
feline lymphoma limited to the nasal cavity.2 A study that
compared the efficacy of the two modalities alone or in combination in a group of 14 cats revealed no statistically different survival times.2 The most important prognostic factor
was not the treatment protocol that was followed, but the
patients FeLV antigenemia. Immunoblastic histologic phenotype and FeLV antigenemia were associated with poor survival rates.2 Patients with systemic disease required chemotherapy, preferably multidrug treatments, including
vincristine, cyclophasphamide, and methotrexate, to achieve
long-term survival.2
As with all feline nasal neoplasms and especially those
patients undergoing radiation therapy or chemotherapy,
supportive care is key. Maintaining adequate nutrition by
supplementing with appetite stimulants, antiemetics, or
placing a feeding tube is very important.1,2 Topical eye care
should be maintained in the acute phase of radiation therapy
to the head.2
Conclusion
Diagnosis of intranasal neoplasms in our dog and cat patients
employs relatively simple diagnostic procedures that can be
completed in a general practice. In most instances, the nature
of radiation therapy then requires referral of the patient to a
specialty facility to administer the most effective treatments.
References
1. Lana SE, Withrow SJ: Tumors of the respiratory systemnasal tumors,
in Withrow SJ, MacEwen EG (eds): Small Animal Clinical Oncology (ed
3). Philadelphia, PA, Saunders, 2001, pp 370-377
2. Moore AS, Ogilvie, GK: Tumors of the respiratory tract, in Ogilvie GK,
Moore AS (eds): Feline Oncology: A Comprehensive Guide to Compassionate Care. Trenton, NJ, Veterinary Learning Systems, 2001, pp 368384
3. Park RD, Beck ER, LeCouteur RA: Comparison of computed tomography and radiography for detecting changes induced by malignant nasal
neoplasia in dogs. J Am Vet Med Assoc 201(11):1720-1724, 1992
4. Codner EC, Lurus AG, Miller JB, et al: Comparison of computed tomography with radiography as a noninvasive diagnostic technique for
chronic nasal disease in dogs. J Am Vet Med Assoc 202(7):1106-1110,
1993
5. Caniatti M, Roccabianca P, Ghisleni G, et al: Evaluation of brush cytology in the diagnosis of chronic intranasal disease in cats. J Small Anim
Pract 39:73-77, 1998
6. Morris JS, Dunn KJ, Dobson JM, et al: Effects of radiotherapy alone and
surgery and radiotherapy on survival of dogs with nasal tumours. J Small
Anim Pract 35:567-573, 1994
7. Adams WM, Bjorling DE, McAnulty JF, et al: Outcome of accelerated
radiotherapy alone or in accelerated radiotherapy followed by exenteration of the nasal cavity in dogs with intranasal neoplasia: 53 cases (19902002). J Am Vet Med Assoc 227(6):936-941, 2005
8. Thon AP, Peaston AE, Madewell BR, et al: Irradiation of nonlymphoproliferative neoplasms of the nasal cavity and paranasal sinuses in 16
cats. J Am Vet Med Assoc 204(1):78-83, 1994
9. Vail DM, Moore AS, Ogilvie GK, et al: Feline lymphoma (145 cases):
proliferation indices, cluster of differentiation 3 immunoreactivity, and
their association with prognosis in 90 cats. J Vet Intern Med 12:349-354,
1998