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120712ChE128-7-LiqLiq Extract
120712ChE128-7-LiqLiq Extract
Basic principles
In liquid-liquid extraction, a soluble component (the solute) moves
from one liquid phase to another. The two liquid phases must be
either immiscible, or partially miscible.
usually isothermal and isobaric
can be done at low temperature (good for thermally fragile
solutes, such as large organic molecules or biomolecules)
can be very difficult to achieve good contact between poorly
miscible liquids (low stage efficiency)
extracting solvent is usually recycled, often by distillation
(expensive and energy-intensive)
Extraction equipment
Batch:
Continuous:
single-stage:
column:
separatory funnel
mixer-settler
rotating-disk contacter
a. agitator; b. stator disk
Design
Mixer-settlers, both as stand-alone and as incolumn type, are offered for special
applications. As implied by the name, the
mixer-settler-column is a series of mixersettlers in the form of a column. It consists of a
stages installed one on top of the
Mixer-settlers operate withnumber
a purelyofstageother,there
eachishydraulically
separated, and each
wise contact. After every mixer
a
with
a mixing
ettler. Mixer-settlers can be
operated
inand
a settling zone (see below).
This design
enables the elimination of some of
multistage, co- or countercurrent
fashion.
the main disadvantages of conventional mixersettlers, whilst maintaining stage-wise phase
contact.
The mechanical design of the mixer-settlercolumn is comparable to the agitated ECR
Khni column.
Key characteristics
For long residence times: >15 min
Extraction controlled by residence
time
Reactive extraction systems
Long phase separation
For extraction controlled by pH
(stage-wise pH adjustment)
Mixer-settler column
points
Agitated column
Stream labeling
feed
solvent
raffinate
mixture
extract
mixer
E, yA,1
settler
F, xA,0
1
SE
solvent flow rate
Solvent (S) extracts A (yA), creating the product = FS = constant
FR
diluent flow rate
= FD = constant
N
S, yA,N+1
R, xA,N
Kd = yA/xA
Note that yA does not refer to gas composition.
Usually specified:
yA,N+1, xA,0, FD/FS and xA,N.
McCabe-Thiele analysis:
Counter-current extraction with immiscible liquids
Equation of the operating line:
FD
FD
Y=
X + (Y1 X )
FS
FS 0
X0
R
R
y = x + (y1 - x0 )
E
E
Can also use Kremser eqns, if solutions
are dilute and equil. line is straight.
mE y N+1 - y 0 mE
ln 1+
R
y
y
R
1
0
N=
ln R
mE
2
3
(X0,Y1)
N=3
(XN,YN+1)
Cross-flow cascade
From mass balance around stage j:
R
R
y j = - xi + (y j,in + x j -1)
Ej
Ej
N=3
Uses much more solvent than countercurrent cascade (requires much more
solvent recovery)
A mixer-settler is just one cross-flow stage.
(x1,y1)
(x2,y2)
(x3,y3)
x3
(x2,y3,in)(x1,y2,in)
(x0,y1,in)
F
zA
zB
solvent 1
yA,N+1 = 0
yB,N+1 = 0
raffinate
xA,N
xB,N
absorbing
section
solvent 2
xA,0 = 0
xB,0 = 0
extract
yA,1
yB,1
stripping
section
A common situation:
R
R
y i = xi + (y i,1 - xi,0 )
E
E
yA,1
N = 4,
F
feed stage
1
6
xA,N
If yA,1 and xB,N are specified, vary NF (trial-and-error)
until N is the same for both solutes.
Center-cut extraction
When there are 3 solutes: A, B and C,
solvent 1
+A
solvent 2
solvent 3
+B
solvent 2
solvent 3
solvent 2
+C
and B is desired
(A and C may be > 1 component each)
Requires two columns:
column 1 separates A from B+C
column 2 separates B from C
F
zA, zB, zC
solvent 1
solvent 2
+B+C
check: xA + xB + xC = 1
Read the mole/mass fraction of each
component on the axis for that component,
using the lines parallel to the edge opposite the
corner corresponding to the pure component.
R
E
M
mixer
settler
coord.:
(yD,yA)
mixing line
F
E
M
tie-line
coord.:
(xD,xA)
Co-linearity
F
S
mixer
solve for coordinates of M: (xA,M, xD,M)
TMB:
F+S=M
rearrange
FxA,F + SxA,S
xA,M =
F +S
xD,M =
xA,M - xA,S
xD,M - xD,S
FxD,F + SxD,S
F +S
xA,F - xA,M
xD,F - xD,M
CMBD
CMBA
F (xD,F, xA,F)
M (xD,M, xA,M)
S (xD,S ,xA,S)
MS
MF
similar triangles
EM
similar triangles
M
MR
M=R+E
R xA,M - y A,E ME
=
=
M xA,R - y A,E RE
S1
F = R0
1
E1
R1
R2
E1
E1
M1
E2
M2
R1
R2
R1
EN
S
mixer
separator
(column)
mixing line
EN
xA,1
M
NOT a
tie-line
R1
Stage-by-stage analysis
R1
xA,1
S = E0
yA,0
stage 1 TMB:
E0 R1 = E1 R2 = E2 R3 etc.
1
E1
R2
F = RN+1
xA,N+1
E 0 + R2 = E 1 + R1
EN
yA,N+1
E0 y A,0 - R1xA,1
D
xD,D =
E0 y D,0 - R1xD,1
D
F = RN+1
EN
S = E0
R1
EN
E2
E1
S = E0
F = RN+1
R3
R2
R1
Stop when you reach or pass EN.
1
extract
compositions
A
yA
xA
0
0
raffinate
compositions
P
equilibrium line ends at P
yA
0
0
xA
S = E0
yA,0
A
yN
xN+1
x1
y0
E0
EN
RN+1
N
F = RN+1
xA,N+1
1
EN
yA,N+1
yA
P
(xN+1, yN)
0 (x1, y0)
xA
A
F
M
Mmin
Mmax
It is not easy to locate this pinch point on a McCabe-Thiele diagram, since the
operating line curvature changes as S changes.
On a Hunter-Nash diagram, Dmin (corresponding to Mmin) occurs when a mixing
line and a tie-line coincide.
N,min
min
1.
2.
3.
4.
5.
min
min
min
N,min
Strategy:
1. Plot S = E0, F = RN+1, R1
2. Join S and F
3. Extend SR1 mixing line
4. Locate several tie-lines
5. Extend tie-lines to SR1
mixing line
6. Find tie-line which gives
closest intersection to S;
this locates Dmin
7. Draw mixing line from Dmin
through F to locate EN,min
8. Connect R1 and EN,min to
complete mass balance
R1
F1
FT
F2
1
mixer 1
R1
M
mixer 2
EN
separator
F2
Feed balance: F1 + F2 = FT
R
N
F1 = RN+1
EN
Overall balance:
hypothetical mixed feedstream FT is co-linear with F1, F2
Stage-by-stage analysis:
mass balance changes where F2 enters the column
upper and lower sections have different sets of operating
lines different D-points
F1
FT
EN
S = E0
F2
R1
Stage-by-stage analysis
E0 = S
R1
1
E
F2
E
N
F1 = RN+1
Overall balance:
F2 + RN+1 + E0 = EN + R1
F2 = (EN RN+1) + (R1 E0) = D1 + D2
j
R
EN
feed-line
EN
F1
feed line
R2
R1
D1
F2
FT
E2
E1
D2
R1
1
makeup solvent
extract reflux
R
E0
R1
N
F1 = RN+1
xA,N+1
EN
yA,N
recovered
solvent
N
RN+1
SR
EN
solvent
separator
PE
product extract
recovered
solvent
N
L0
SR
D
RN+1
reflux
EN
solvent
separator
PE
product extract
Stage-by-stage balances
Similar to 2-feed liq-liq extraction column:
- two D-points (mass balance above and below feed stage)
- if F, E0, R1 and RN+1 are specified, same stage-by-stage analysis
But RN+1 is an internal stream, usually not specified.
Usually specified:
F, xA,F, xD,F
yA,0, yD,0
xA,1
xA,PE, xD,PE
rates)
yA,SR, yD,SR
RN+1/PE
plot F
plot E0
plot R1 on satd raffinate curve
plot PE (same location as RN+1 and Q, different flow
plot SR
EN = Q + SR
solvent
separator
= RN+1 + PE + SR
Q
PE
EN SR RN+1
S
=
+ 1+ R
SR PE
PE
PE
EN
SR
E0
PE, Q, RN+1
F
R1
RN+1
+1
PE
R
E
P
SR
N+1 = N - E - 1
=
SR
SR SR
EN
PE
1
S
R
EN y A,N - RN+1xA,N+1
EN - RN+1
D1 = E0 - R1
D1
F = D1 + D2
Proceed to step off stages.
PE, Q, RN+1
SREN
E0
R1