Pathophysiology of Respiratory Alkalosis

low partial pressure of oxygen in arterial blood

and abnormal range of PCO2

Increase rate and depth of ventilation

Hyperventilation

Hypocapnea

Hyponatremia

As the concentration of sodium decreases in ECF, fluid becomes hypo- osmolar

Water moves to the area of greater concentration

Intracellular edema

Brain stem herniation

Seizures

Respiratory arrest

DEATH
 Pathophysiology of
Respiratory Alkalosis

Submitted to:

Mrs. Leslie Marie C. Uyson

Submitted by:

Hanna Krisselle T. Luzano

Marren Fatima P. Matibag

BSN 142
 Modifiable Risk Factors Non- Modifiable Risk Factors
- hyperventilation - age
- hypoxia - gender
- fever
- disease (pneumonia, asthma)

Low partial pressure of oxygen in arterial blood

and abnormal range of PCO2

Peripheral chemoreceptor low blood flow

(shock)

Aortic Arch Carotid Bodies

Respiratory center
Alveolar-capillary membrane

Increase rate and depth of ventilation J Receptor

Thickening of the alveolar-capillary membrane

Changes in ionization of structural and regulatory proteins

Widespread organ dysfunction

Cellular shifts Increase binding of Ca 2+ to serum proteins

Electrolyte imbalance

Respiratory Alkalosis

Acute Respiratory Alkalosis Chronic Respiratory Alkalosis

Shifting of acid from intracellular Adaptive increase production Stimulation of

Glycolysis
 fluid into blood of lactic acid

Movement of HCO3- into cells in Decreased H+ secretion

exchange for Cl- as well as excretion of Renal compensation
excess filtered HCO3-