Pathophysiology of

Ebola Virus
Disease
D R. R U T H M . S A N T O S

Ebola Virus can enter into:

Broken Skin
Mucous Membrane

Ebola Virus can Infect:

Endothelial Cells (Cells lining, B.V.)
Liver cells

Immune Cells
Macrophages, monocyte
Dendritic cells

Endotheli
al Cells

Immune
Cells

Within 3 days of
infection
Vascular Injury
Attributed to EBOV
glycoproteins

Macrophages 1st cells

infected
Carry virus to the
lymph nodes for
further replication.

When EBOV attacks the Immune

Cells:
Macrophages:
1st cells
infected

Infection results to
programmed cell death
with other WBC
Low concentration of
lymphocytes
Weaken immune
response

When the
The Virus is spread
virus is in
throughout the
lymph nodes
body through
for further
lymphatic system
and blood stream
replication

Vascular Injury Attributed to EBOV glycoproteins results to:

Viral particles
damage cells
from viral
budding out of
the cells. It also
release
chemicals TNFa
IL-6 & IL-8 which
are molecular
signals for fever
and
inflammation

Hemorrhage,Ed
ema and
hypovolemic
shock

Increase Synthesis
of Glycoprotein,
thus decreases
specific integration
(responsible for
cells adhesions to
intracellular
structure)
Damage Liver Cells
Improper clotting
and dysfunction in
bleeding and
clotting