Freedom Meditech ~ Selected published peer-reviewed scientific and/or | 2043 medical journal articles Selected Journal Articles / References Selected published peer-reviewed scientific and/or medical journal articles covering discussions on relationship between Diabetes, Advanced Glycated Endproducts (AGEs), Fluorescence, Age and related lenticular deterioration Fluorescence and Diabetes 1.Mosier MA, Occhipinti JR, Burstein NL. Autofluorescence of the crystalline lens in diabetes. Arch Ophthalmol. Sep 1986;104(9):1340-1343. 2. Sparrow JM, Bron AJ, Brown NA, Neil HA. Autofluorescence of the crystalline lens in early and late onset diabetes. Br J Ophthalmol. Jan 1992;76(1):25-31. 3, Helve J, Nieminen H. Autofluorescence of the human diabetic lens in vivo. Am J Ophthalmol, Apr 1976;81(4):493-494. 4. Bleeker JC, van Best JA, Vrij L, van der Velde EA, Oosterhuis JA. Autofluorescence of the lens in diabetic and healthy subjects by fluorophotometry. Invest Ophthalmol Vis Sci. May 1986;27(5):791-794. 5. van Wirdum E, van Best J, Bruining GJ, de Beaufort C, Oosterhuis J. Bloodretinal and blood-aqueous barrier permeability, lens autofluorescence and transmission in insulin- dependent diabetic youngsters. Graefes Arch Clin Exp Ophthalmol. 989;227(1):26-29. 6. Mori F, Ishiko S, Abiko T, et al. Changes in corneal and lens autofluorescence and blood glucose levels in diabetics: parameters of blood glucose control. Curr Eye Res. Jun 1997;16(6):534-538. 7. Ishiko S, Yoshida A, Mori F, et al. Corneal and lens autofluorescence in young insulin- dependent diabetic patients. Ophthalmologica. 1998;212(5):301-305. 8. Liang JN. Fluorescence study of the effects of aging and diabetes mellitus on human lens alpha-crystallin. Curr Eye Res. Feb 1987;6(2):351-355, 9. Silva J, Freitas JP, Filipe P, Vendrell E, Rodrigo FG. [Fluorescent products in the crystalline lens of type ii diabetic patients]. Acta Med Port. Jul-Sep 1996;9(7-9):237-239. Woreeioetiniies Vision fora Hester Lite onder: Noto Be Dstbuted Wino te Expres Peston of Freedom Medtech in.Freedom Meditec! elected published pee viewed scientific and/or | 2013 medical journal articles 10. Bordat B, Arnaud C, Guirguis IR, Laudeho A. Fluorophotometric study of lens autofluorescence and the blood-retinal barrier in 56 diabetic patients. Eur J Ophthalmol. Jan-Mar 1995;5(1):13-18. 11. van Boekel MA, Hoenders HJ. Glycation of crystallins in lenses from aging and diabetic individuals. FEBS Lett. Dec 7 1992;314(1):1-4. 12. Lerman S. In vivo lens fluorescence as a cataract marker. Dev Ophthalmol. 1989;17:60- 64. 13. Kjer B, Larsen M, Bendtson I, Binder C, Dalgaard P, Lund-Andersen H. Lens autofluorescence in diabetes compared with the level of glycosylated hemoglobin Alc. Acta Ophthalmol Suppl. 1987;182(S182):100-102. 14. Koefoed Theil P, Hansen T, Larsen M, Pedersen O, Lund-Andersen H. Lens autofluorescence is increased in newly diagnosed patients with NIDDM. Diabetologia. Dec 1996;39(12):1524-1527. 15. Kessel L, Sander B, Dalgaard P, Larsen M. Lens fluorescence and metabolic control in type 1 diabetic patients: a 14 year follow up study. Br J Ophthalmol, Sep 2004;88(9):1169- 1172 16. Koefoed Theil P, Kessel L, Hansen T, Lund-Andersen H, Pedersen O, Larsen M. Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study. Curr Eye Res. Sep 2006;31(9):733-738. (2012 01 25 Freedom 510(k) Library) Page: 2 17. Larsen M, Kjer B, Bendtson |, Dalgaard P, Lund-Andersen H. Lens fluorescence in relation to metabolic control of insulin-dependent diabetes mellitus. Arch Ophthalmol. Jan 1989;107(1):59-62. 18. Larsen M, Kjer B, Bendtson I, Dalgaard P, Lund-Andersen H. Lens fluorescence in relation to nephropathy in insulin-dependent diabetes mellitus. Graefes Arch Clin Exp Ophthalmol. 1992;230(1):6-10. 19. Zeimer RC, Noth JM. A new method of measuring in vivo the lens transmittance, and study of lens scatter, fluorescence and transmittance. Ophthalmic Res. 1984;16(5):246-255. 20. Bailey AJ, Sims‘T), Avery NC, Halligan EP. Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose. Biochem J. Jan 15 1995;30S ( Pt 2):385-390. FreedomMeditech onfdeml Not tote Ditbuted Wihout th Express Permton freedom Made, Ine, “#00 for Mester LieFreedom Meditech - Selected published peer-reviewed scientific and/or | 2913 medical journal articles 21, Sell DR, Nemet I, Monnier VM. Partial characterization of the molecular nature of collagen-linked fluorescence: role of diabetes and end-stage renal disease. Arch Biochem Biophys. Jan 15 2010;493(2):192-206 22. Hashimoto H, Arai K, Yoshida S, Chikuda M, Obara Y. Pentosidine and autofluorescence in lenses of diabetic patients. Jpn J Ophthalmol. Sep-Oct 1997;41(5):274-277. 23. Mota MC, Carvalho P, Ramalho JS, Cardoso E, Gaspar AM, Abreu G. Protein glycation and in vivo distribution of human lens fluorescence. Int Ophthalmol, 1994;18(4):187-193, 24, Meerwaldt R, Graaff R, Oomen PH, et al. Simple non-invasive assessment of advanced glycation endproduct accumulation. Diabetologia. Jul 2004;47(7): 1324-1330. 25. Beneyto P, Alonso I, Perez TM, Lopez L, Fonseca A. Study of lens autofluorescence by fluorophotometry in pregnant patients with diabetes. Ophthalmology. May 1996;103(5):822-826. Fluorescence and AGEs/Glycation 1.Schmitt A, Schmitt J, Munch G, Gasic-Milencovic J. Characterization of advanced glycation end products for biochemical studies: side chain modifications and fluorescence characteristics. Anal Biochem. Mar 15 2005;338(2):201-215. 2, Ahmed N, Thornalley PJ. Chromatographic assay of glycation adducts in human serum. albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl- carbamate and intrinsic fluorescence. Biochem J. May 15 2002;364(Pt 1):15-24. 3. Munch G, Keis R, Wessels A, et al. Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. Sep 1997;35(9):669-677 4. Bhattacharyya J, Shipova EV, Santhoshkumar P, Sharma KK, Ortwerth BJ. Effect of a single AGE modification on the structure and chaperone activity of human alphaB- crystallin. Biochemistry. Dec 18 2007;46(50):14682-14692. 5. Das BK, Sun TX, Akhtar NJ, Chylack LT, Jr., Liang JJ. Fluorescence and immunochemical studies of advanced glycation-related lens pigments. Invest Ophthalmol Vis Sci. Oct 1998;39(11):2058-2066. FreedomMeditech Von fora Healer fe ‘Confident not to Be Dsrbute Without he Express Permission of Freedom Meech, neand/or | 2013 medical journal articles 6. van Boekel MA, Hoenders HJ. Glycation of crystallins in lenses from aging and diabetic individuals. FEBS Lett. Dec 7 1992;314(1):1-4. 7. Miyata T, Wada Y, Cai Z, et al. Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure. Kidney int. Apr 1997;51(4):1170-1181. 8, Meerwaldt R, Links TP, Graaff R, et al. Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy. Diabetologia. Aug 2005;48(8): 1637-1644. 9. Kessel L, Hougaard JL, Sander B, Kyvik KO, Sorensen TI, Larsen M. Lens ageing as an indicator of tissue damage associated with smoking and nonenzymatic glycation--a twin study. Diabetologia. Oct 2002;45(10):1457-1462. 10. Bailey AJ, Sims TJ, Avery NC, Halligan EP. Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose. Biochem J. Jan 15 1995;305 ( Pt 2):385-390. 11. Mota MC, Carvalho P, Ramalho JS, Cardoso E, Gaspar AM, Abreu G, Protein glycation and in vivo distribution of human lens fluorescence. Int Ophthalmol. 1994;18(4):187-193. 12. Cheng R, Lin B, Ortwerth BJ. Rate of formation of AGEs during ascorbate glycation and during aging in human lens tissue. Biochim Biophys Acta, May 21 2002;1587(1):65-74. 13. Scalbert P, Birlouez-Aragon I Relationship between lens protein glycation and membrane structure in human cataract. Exp Eye Res. Mar 1993;56(3): 335-340. 14, McPherson JD, Shilton BH, Walton DJ. Role of fructose in glycation and cross(2012 01 25 Freedom 510(k) Library) Page: 2 linking of proteins. Biochemistry. Mar 22 1988;27(6):1901-1907. 15. Meerwaldt R, Graaff R, Oomen PH, et al. Simple non-invasive assessment of advanced glycation endproduct accumulation. Diabetologia. Jul 2004;47(7): 1324-1330, 16. Meerwaldt R, Hartog JW, Graaff R, et al. Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. Journal of the American Society of Nephrology : JASN. Dec 2005;16(12):3687-3693. FreedomMeditech ion fra Healthier ite Confident! Not to Be Distributed Without he Express ermiton of Freedom Medtech, ne.jewed scientific and/or | 2013 medical journal articles Diabetes and AGEs/Glycation Vidal P, Cabezas-Cerrato J. Accumulation of glycation products in alpha-H pig lens crystallin and its bearing to diabetic cataract genesis. Acta Ophthalmol (Copenh). Oct 1988;66(5):589-592. 2. Basta G, Schmidt AM, De Caterina R. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res. Sep 1 2004;63(4):582-592. 3. Zarina S, Zhao HR, Abraham EC. Advanced glycation end products in human senile and diabetic cataractous lenses. Mol Cell Biochem. Jul 2000;210(1-2): 29-34. 4. Gul A, Rahman MA, Salim A, Simjee SU. Advanced glycation end products in senile diabetic and nondiabetic patients with cataract. / Diabetes Complications. Sep-Oct 2009;23(5):343-348. 5. Yu Y, Thorpe SR, Jenkins AJ, et al. Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes. Diabetologia. Oct 2006;49(10):2488-2498. 6. Nicholl ID, Bucala R. Advanced glycation endproducts and cigarette smoking, Cell Mol Biol (Noisy-le-grand). Nov 1998;44(7):1025-1033. 7. Pokupec R, Kalauz M, Turk N, Turk Z. Advanced glycation endproduets in human diabetic and non-diabetic cataractous lenses. Graefes Arch Clin Exp Ophthalmol. May 2003;241(5):378-384. 8. Meerwaldt R, Links T, Zeebregts C, Tio R, Hillebrands JL, Smit A. The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes. Cardiovasc Diabetol. 2008;7(1):29. 9, Stevens A. The contribution of glycation to cataract formation in diabetes. J Am Optom Assoc. Aug 1998;69(8):519-530, 10. Ramalho J, Marques C, Pereira P, Mota MC. Crystallin composition of human cataractous lens may be modulated by protein glycation. Graefes Arch Clin Exp Ophthalmol. Aug 1996;234 Suppl 1:232-238. FreedomMeditech Vision fr» Healthier Lite Confinti! not to Be Dtbvted Without te Expres Permision of freedom Medtech IeFreedom Meditech - Selected published peer-reviewed scientific and/or | 2013 medical journal articles 11, Lyons T], Bailie KE, Dyer DG, Dunn JA, Baynes JW. Decrease in skin collagen glycation with improved glycemic control in patients with insulindependent diabetes mellitus. J Clin Invest. Jun 1991;87(6):1910-1915. 12. Beranek M, Novakova D, Rozsival P, Drsata J, Palicka V. Glycation and advanced glycation end-products in laboratory experiments in vivo and in vitro. Acta Medica (Hradec Kralove). 2006;49(1):35-39. 13. Oimomi M, Maeda Y, Hata F, etal. Glycation of cataractous lens in nondiabetic senile subjects and in diabetic patients. Exp Eye Res. Mar 1988;46(3):415-420, 14. van Boekel MA, Hoenders HJ. Glycation of crystallins in lenses from aging and diabetic individuals. FEBS Lett. Dec 7 1992;314(1):1-4. 15. Swamy MS, Abraham A, Abraham EC. Glycation of human lens proteins: preferential glycation of alpha A subunits. Exp Eye Res. Mar 1992;54(3): 337-345. 16. Cooper ME. Importance of advanced glycation end products in diabetes( 2012 01 25 Freedom 510(k) Library) Page: 2 associated cardiovascular and renal disease. Am J Hypertens. Dec 2004;17(12 Pt 2):31S-388. 17. Franke $, Dawezynski J, Strobel J, Niwa T, Stahl P, Stein G. Increased levels of advanced glycation end products in human cataractous lenses. J Cataract Refract Surg. May 2003;29(5):998-1004. 18. Yamagishi S, Matsui T, Nakamura K. Kinetics, role and therapeutic implications of endogenous soluble form of receptor for advanced glycation end products (sRAGE) in diabetes. Curr Drug Targets. Oct 2007;8(10): 1138-1143, 19. Vidal P, Fernandez-Vigo J, Cabezas-Cerrato J. Low glycation level and browning in human cataracts. Acta Ophthalmol (Copenh). Apr 1988;66(2): 220-222. 20. Tessier FJ. The Maillard reaction in the human body. The main discoveries and factors that affect glycation. Pathol Biol (Paris). Jun 2010;58(3):214-219. 21. Mendez JD, Xie J, Aguilar-Hernandez M, Mendez-Valenzuela V. Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases. Mol Cell Biochem. Nov 2010;344(1-2):185-193. 22. Bailey AJ, Sims TJ, Avery NC, Halligan EP. Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose. Biochem J. Jan 15 1995;305 ( Pt 2):385-390. FreedomMeditech Confident Nott Be Distributed Without the Expres Pemtsion of redem Medtech ine, | Wlon fra Healthier Life23. Garlick RL, Mazer JS, Chylack LT, jr, Tung WH, Bunn HF. Nonenzymatic glycation of human lens crystallin. Effect of aging and diabetes mellitus. J Clin invest. Nov 1984;74(5):1742-1749. 24. Krantz S, Lober M, Henschel L. The nonenzymatic glycation of proteins and nucleic acids, their importance for the development of diabetic complications, possible molecular basis of aging and autoimmunological processes. Exp Clin Endocrinol. Dec 1986;88(3):257- 269. 25. Mota MC, Carvalho P, Ramalho JS, Cardoso E, Gaspar AM, Abreu G. Protein glycation and in vivo distribution of human lens fluorescence. int Ophthalmol, 1994;18(4):187-193. 26. Ulrich P, Cerami A. Protein glycation, diabetes, and aging. Recent Prog Horm Res. 2001;56:1-21. 27. Sims TJ, Rasmussen LM, Oxlund H, Bailey AJ. The role of glycation crosslinks in diabetic vascular stiffening, Diabetologia. Aug 1996;39(8):946-951. 28. Ramalho JS, Marques C, Pereira PC, Mota MC. Role of glycation in human lens protein structure change. Eur J Ophthalmol. Apr-Jun 1996;6(2):155-161, 29, Meerwaldt R, Graaff R, Oomen PH, et al. Simple non-invasive assessment of advanced glycation endproduct accumulation. Diabetologia. Jul 2004;47(7): 1324-1330. 30. Liang JN, Chylack LT, Jr. Spectroscopic study on the effects of nonenzymatic glycation in human alpha-crystallin. Invest Ophthalmol Vis Sci. May 1987;28(5):790-794. 31. Brown SM, Smith DM, Alt N, Thorpe SR, Baynes JW. Tissue-specific variation (2012 01 25 Freedom 510(k) Library) Page: 3 in glycation of proteins in diabetes: evidence for a functional role of amadoriase enzymes. Ann N Y Acad Sci. Jun 2005;1043:817-823. Aging and AGEs/Glycation 1.Gul A, Rahman MA, Salim A, Simjee SU. Advanced glycation end products in senile diabetic and nondiabetic patients with cataract. J Diabetes Complications. Sep-Oct 2009;23(5):343-348, 2. Horiuchi S, Araki N. Advanced glycation end products of the Maillard reaction and their relation to aging, Gerontology. 1994;40 Suppl 2:10-15. ‘FreedomMeditech Confident Hot to Be Dstrbuted Wrhout the xpress Perms of Freedom Medtech In, Vio fora Heather LifeFreedom Meditecl viewed scientific and/or | 2013 medical journal articles 3. Yu Y, Thorpe SR, Jenkins AJ, et al. Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes. Diabetologia. Oct 2006;49(10):2488-2498. 4. Nicholl ID, Bucala R. Advanced glycation endproducts and cigarette smoking. Cell Mol Biol (Noisy-le-grand). Nov 1998;44(7):1025-1033. 5. de La Rochette A, Birlouez-Aragon |, Silva E, Morliere P. Advanced glycation endproducts as UVA photosensitizers of tryptophan and ascorbic acid: consequences for the lens. Biochim Biophys Acta. jun 11 2003;1621(3): 235-241. 6. Pokupec R, Kalauz M, Turk N, Turk Z. Advanced glycation endproducts in human diabetic and non-diabetic cataractous lenses. Graefes Arch Clin Exp Ophthalmol. May 2003;241 (5):378-384. 7. Jiaan DB, Seftel AD, Fogarty J, et al. Age-related increase in an advanced glycation end product in penile tissue. World J Urol. 1995;13(6):369-375. 8. Verzijl N, DeGroot J, Ben ZC, et al. Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis and rheumatism. Jan 2002;46(1):114-123. 9. Ramalho J, Marques C, Pereira P, Mota MC. Crystallin composition of human cataractous lens may be modulated by protein glycation. Graefes Arch Clin Exp Ophthalmol. Aug 1996;234 Suppl 1:5232-238. 10. Munch G, Keis R, Wessels A, et al. Determination of advanced glycation end products in serum by fluorescence spectroscopy and competitive ELISA. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. Sep 1997;35(9):669-677. 11. Verzijl N, DeGroot J, Thorpe SR, et al. Effect of collagen turnover on the accumulation of advanced glycation end products. J Biol Chem. Dec 15 2000;275(50):39027-39031. 12. Beranek M, Novakova D, Rozsival P, Drsata J, Palicka V. glycation end-products in laboratory experiments in vivo an Kralove). 2006;49(1):35-39. lycation and advanced vitro, Acta Medica (Hradec FreedomMeditech Confident! Not to Be Dstrbates Without the xpress Prmistion of Freedom Meitec, ne, Vion for # Healthier LifeSelected published peer-reviewed scientific and/or | 2013 medical journal articles 13. Linetsky M, Shipova E, Cheng R, Ortwerth BJ. Glycation by ascorbic acid oxidation products leads to the aggregation of lens proteins. Biochim Biophys Acta. Jan 2008;1782(1):22-34. 14. Oimomi M, Maeda Y, Hata F, et al. Glycation of cataractous lens in nondiabetic senile subjects and in diabetic patients. Exp Eye Res. Mar 1988;46(3):415-420. 15. van Boekel MA, Hoenders HJ. Glycation of crystallins in lenses from aging (2012 01 25 Freedom 510(k) Library) Page: 2 and diabetic individuals. FEBS Lett, Dec 7 1992;314(1):1- 4. 16, Duhaiman AS. Glycation of human lens proteins from diabetic and (nondiabetic) senile cataract patients. Glycoconj J. Oct 1995;12(5):618-621. 17. Swamy MS, Abraham A, Abraham EC. Glycation of human lens proteins: preferential glycation of alpha A subunits. Exp Eye Res. Mar 1992;54(3): 337-345. 18. Araki N, Ueno N, Chakrabarti B, Morino Y, Horiuchi S, Immunochemical evidence for the presence of advanced glycation end products in human lens proteins and its positive correlation with aging. J Biol Chem. May 25 1992;267(15):10211-10214. 19. Ling X, Sakashita N, Takeya M, Nagai R, Horiuchi S, Takahashi K. Immunohistochemical distribution and subcellular localization of three distinct specific molecular structures of advanced glycation end products in human tissues. Laboratory investigation; a journal of technical methods and pathology. Dec 1998;78(12):1591-1606. 20. Meerwaldt R, Links TP, Graaff R, et al. Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy. Diabetologia. Aug 2005;48(8): 1637-1644 21. Franke S, Dawczynski J, Strobel J, Niwa T, Stahl P, Stein G. Increased levels of advanced glycation end products in human cataractous lenses. J Cataract Refract Surg, May 2003;29(5):998-1004, 22. Nicholl ID, Stitt AW, Moore JE, Ritchie AJ, Archer DB, Bucala R. Increased levels of advanced glycation endproducts in the lenses and blood vessels of cigarette smokers. Mol Med. Sep 1998;4(9):594-601. 23. Kessel L, Hougaard JL, Sander B, Kyvik KO, Sorensen TI, Larsen M. Lens ageing as an indicator of tissue damage associated with smoking and nonenzymatic glycation--a twin study. Diabetologia. Oct 2002;45(10):1457-1462 FreedomMeditech Confer Nott Be Ditibvted Without the Expres Perms of redo Mediech reFreedom Meditech - Selected published peer-reviewed scientific and/or | 2013 medical journal articles 24. Vidal P, Fernandez-Vigo J, Cabezas-Cerrato J. Low glycation level and browning in human cataracts. Acta Ophthalmol (Copenh). Apr 1988;66(2): 220-222. 25. Tessier F]. The Maillard reaction in the human body. The main discoveries and factors that affect glycation. Pathol Biol (Paris). Jun 2010;58(3):214-219. 26. Ahmed N, Thornalley PJ, Dawezynski J, et al. Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins. Invest Ophthalmol Vis Sci. Dec 2003;44(12):5287-5292 27. Reddy S, Bichler J, Wells-Knecht KJ, Thorpe SR, Baynes JW. N epsilon- (carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins. Biochemistry. Aug 29 1995;34(34):10872-10878. 28. Bailey AJ, Sims T], Avery NC, Halligan EP. Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose. Biochem J. Jan 15 1995;305 ( Pt 2):385-390. 29, Garlick RL, Mazer JS, Chylack LT, Jr., Tung WH, Bunn HF, Nonenzymatic (2012 01 25 Freedom 510(k) Library) Page: 3 glycation of human lens crystallin. Effect of aging and diabetes mellitus. J Clin Invest, Nov 1984;74(5):1742-1749. 30. Krantz S, Lober M, Henschel L. The nonenzymatic glycation of proteins and nucleic acids, their importance for the development of diabetic complications, possible molecular basis of aging and autoimmunological processes. Exp Clin Endocrinol. Dec 1986;88(3):257- 269. 31, Mota MC, Carvalho P, Ramalho JS, Cardoso E, Gaspar AM, Abreu G. Protein glycation and in vivo distribution of human lens fluorescence. Int Ophthalmol, 1994;18(4):187-193, 32. Ulrich P, Cerami A. Protein glycation, diabetes, and aging. Recent Prog Horm Res, 2001;56:1-21. 33. Cheng R, Lin B, Ortwerth BJ. Rate of formation of AGEs during ascorbate glycation and during aging in human lens tissue. Biochim Biophys Acta, May 21 2002;1587(1):65-74. 34, Scalbert P, Birlouez-Aragon I. Relationship between lens protein glycation and membrane structure in human cataract. Exp Eye Res. Mar 1993;56(3): 335-340. 35. Sims TJ, Rasmussen LM, Oxlund H, Bailey AJ. The role of glycation crosslinks in diabetic vascular stiffening. Diabetologia. Aug 1996;39(8):946-951. FreedomMeditech Confident! Not to Be isibuted Without the Expres Rermlsion of Freedom Medtech In.” Vin ora Heater Lifeelected published pes jewed scientific and/or | 2043 medical journal articles 36. Lee AT, Cerami A. Role of glycation in aging. An NY Acad Sci. Nov 21 1992;663(1):63- 70. 37. Ramalho JS, Marques C, Pereira PC, Mota MC. Role of glycation in human lens protein structure change. Eur J Ophthalmol. Apr-Jun 1996;6(2):155-161 38, Lyons TJ, Silvestri G, Dunn JA, Dyer DG, Baynes JW. Role of glycation in modification of lens crystallins in diabetic and nondiabetic senile cataracts. Diabetes. Aug 1991;40(8):1010-1015. 39. Frye EB, Degenhardt TP, Thorpe SR, Baynes JW. Role of the Maillard reaction in aging of tissue proteins. Advanced glycation end productdependent increase in imidazolium cross- links in human lens proteins. J Biol Chem. Jul 24 1998;273(30):18714-18719. 40. Meerwaldt R, Graaff R, Oomen PH, et al. Simple non-invasive assessment of advanced glycation endproduct accumulation. Diabetologia. jul 2004;47(7): 1324-1330. 41, Meerwaldt R, Hartog JW, Graaff R, et al. Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. Journal of the American Society of Nephrology : JASN. Dec 2005;16(12):3687-3693. 42, Liang JN, Chylack LT, Jr. Spectroscopic study on the effects of nonenzymatic glycation in human alpha-crystallin. Invest Ophthalmol Vis Sci. May 1987;28(5):790-794. FreedomMeditech Vion fora Helier Lite Confidemil not to Be Dizbute Wihout he xpress Parmition of Freedom Mec, ne