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Depression and Neurocognitive Performance in Portuguese Patients Infected With HIV
Depression and Neurocognitive Performance in Portuguese Patients Infected With HIV
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This study focused on neurocognitive disorders associated with HIV infection,
characterizes the most affected neuropsychological domains and their potential as factors
related with depression. 130 HIV-positive individuals with CD4 >200 cells/mm super(3),
undetectable viral load, treated with HAART and with all kinds of risk behaviors were
included. A structured interview composed by seven sections was used and relevant clinical
and laboratory data was assessed. For the neuropsychological and depression assessment
the HIV Neurobehavioral Research Center (HNRC) Battery and Hamilton Rating Scale for
Depression (HAM-D) were chosen. Univariate nonparametric statistics and multivariate
regression model were performed. Among 34% of depressed subjects, 20.7% had attempted
suicide, 45.4% were under psychiatric medication and only 19% had no diagnostic criteria
for HIV Associated Neurocognitive Disorders (HAND). The effect of depression on
cognitive function revealed a significant deterioration in five of the eight measures. In the
multivariate analysis, five variables significantly determined depression: sex, social class,
antidepressant medication, history of suicide attempt and Dexterity and motor speed
(neuropsychological test battery). Despite good patient adherence to treatment (HAART
and antidepressive) and good immune status, the prevalence of HAND and depression are
high and suggest a significant relation between severity of depression and cognitive
functioning.Original Abstract: Este estudio se centra en los trastornos neurocognitivos
asociados a la infeccion por el VIH, caracteriza los dominios neuropsicologicos mas
afectados y su potencial relacion con la depresion. Fueron incluidos en el estudio 130
individuos VIH-positivos con CD4 >200 celulas/mm super(3), carga viral indetectable,
medicados con HAART abarcando todos los comportamientos de riesgo. Fue utilizada una
entrevista estructurada compuesta por siete secciones y se evaluaron los datos clinicos y de
laboratorio. Para la evaluacion neuropsicologica y la depresion fueron elegidas la bateria de
lo HNRC (HIV Neurobehavioral Research Center) y la Escala de Hamilton para Depresion
(HAM-D). Se utilizaran estadisticas univariantes no parametricas y el modelo de regresion
multivariante. Entre el 34% de los sujetos deprimidos, el 20,7% habia intentado suicidarse,
el 45,4% hacian medicacion psiquiatrica, y solo el 19% carecia de criterios para el
diagnostico trastornos neurocognitivos asociado al VIH (HAND). El efecto de la depresion
sobre la funcion cognitiva revela un deterioro significativo en cinco de las ocho medidas.
En el analisis multivariado, cinco variables se asocian significativamente con la depresion:
Indexacin (detalles)
Citar
Materia
Immune status;
Depression;
Data processing;
Statistical analysis;
Suicide;
Hand;
Infection;
Cognition;
Antidepressants;
CD4 antigen;
Multivariate analysis;
Cognitive ability;
highly active antiretroviral therapy;
Regression analysis;
Sex;
Acquired immune deficiency syndrome;
social class;
cognitive ability;
Human immunodeficiency virus;
infection;
Drugs;
depression;
suicide
Clasificacin
R2 23110: Psychological aspects
V 22360: AIDS and HIV
Ttulo
Depression and Neurocognitive Performance in Portuguese Patients Infected with HIV
Autor
Braganca, Miguel 1 ; Palha, Antonio
1
miguelbraganca@netcabo.pt
Ttulo de publicacin
AIDS and Behavior
Tomo
15
Nmero
8
Pginas
1879-1887
Nmero de pginas
9
Ao de publicacin
2011
Ao
2011
Editorial
Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX
Netherlands
ISSN
1090-7165
eISSN
1573-3254
Tipo de fuente
Scholarly Journals
Artculos evaluados por expertos
S
Idioma del resumen
English
Idioma de la publicacin
English
Tipo de documento
Journal Article
Subarchivo
Virology & AIDS Abstracts; Risk Abstracts
DOI
http://dx.doi.org/10.1007/s10461-011-9973-3
Actualizar
2012-03-01
Nmero de acceso
16350736
ID del documento de ProQuest
926889874
URL del documento
http://search.proquest.com/docview/926889874?accountid=14598
ltima actualizacin
2013-09-09