Schizophrenia

Definition
Chronic psychotic disorder that show marked
disturbance in mood,thought, and behavior that
lead to impaired function and deterioration of
personality.

Epidemiology
Equally prevalent in men and women
Lifetime prevalance = 1%
Peak age of onset
male: 15-25
female :25-33

Symptoms
Positive

Delusion
Hallucination
= usually respond
to typical
antipsychotic

Negative
Motor behaviour
Avolition
Emotion
Flattening of affect
Marked social
withdrawal.
= improve on atypical
anti psychotic,
psychotherapy,
rehabilitation therapy.

Diagnosis
Disturbance that last for at least 6 month duration
+ at least one month of active phase symptoms.
Active phase symptom= presence of at least 2 or
more domains abnormalities with at least one of
the highlighted domain of .
Domains.
Delusion
hallucination,
disorganized thinking
Grossly disorganize/abnormal behaviour
(eg=catatonia)
Negative symptoms

Types
Type

Symptoms

Paranoid

One or more delusion

Frequent hallucination
Disorganize speech,behaviour,affect not prominent
Social and occupational deterioration lesser than others

Disorganiz
ed

All symptoms present

Delusions are bizarre,fragmented
Formal thought disorder
Behaviour are grossly disorganized
Marked social and occupational deterioration

Catatonic

Catatonic feature predominate

Other symptoms may present
Profound social and occupational deterioration

Type

Symptoms

Undifferentiated

Intermediate between paranoid and

disorganized
Lesser symptoms than paranoid
( delusion,hallucination ) and disorganized
(disorganization)
Occupational and social
deterioration=intermediate

Residual

Lesser symptoms than undifferentiated

Result of partial improvement of treatment

Simple

No positive symptoms
Only vague thinking,flat affect,social withdrawal
Very gradual occupational deterioration
Start early adolescence
Early onset,slow progressive course
Family usually recognize the changes after many
years of deterioration
One of most malignant type.