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  • CMN Group:: Unusual Cell Wall Lipids (Mycolic Acids, Etc.)

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    Ratu Rosaline Megawiranto Putri
    9 views15 pages
    This document discusses Mycobacterium, a genus of bacteria that includes pathogens like M. tuberculosis and M. leprae. It covers topics like the unusual lipid composition of the mycobacterial cell wall containing mycolic acids; acid-fast staining techniques used to identify mycobacteria; clinical syndromes caused by pathogenic mycobacterial species; the formation of granulomas in the lungs during tuberculosis infection; laboratory diagnosis methods including nucleic acid probes and sequencing; M. leprae infections and the clinical manifestations of lepromatous and tuberculoid leprosy depending on immune response.

    Original Description:

    mycobacterium

    Original Title

    Lecture Pp 25 My Co Bacterium

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    This document discusses Mycobacterium, a genus of bacteria that includes pathogens like M. tuberculosis and M. leprae. It covers topics like the unusual lipid composition of the mycobacterial cell wall containing mycolic acids; acid-fast staining techniques used to identify mycobacteria; clinical syndromes caused by pathogenic mycobacterial species; the formation of granulomas in the lungs during tuberculosis infection; laboratory diagnosis methods including nucleic acid probes and sequencing; M. leprae infections and the clinical manifestations of lepromatous and tuberculoid leprosy depending on immune response.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    9 views15 pages

    CMN Group:: Unusual Cell Wall Lipids (Mycolic Acids, Etc.)

    Uploaded by

    Ratu Rosaline Megawiranto Putri
    This document discusses Mycobacterium, a genus of bacteria that includes pathogens like M. tuberculosis and M. leprae. It covers topics like the unusual lipid composition of the mycobacterial cell wall containing mycolic acids; acid-fast staining techniques used to identify mycobacteria; clinical syndromes caused by pathogenic mycobacterial species; the formation of granulomas in the lungs during tuberculosis infection; laboratory diagnosis methods including nucleic acid probes and sequencing; M. leprae infections and the clinical manifestations of lepromatous and tuberculoid leprosy depending on immune response.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 15

    Lipid-Rich Cell Wall of Mycobacterium

    Mycolic acids

    CMN Group:
    Unusual cell wall
    lipids (mycolic
    acids,etc.)
    (Purified Protein Derivative)

    Acid-Fast (Kinyoun) Stain of


    Mycobacterium

    NOTE: cord growth (serpentine


    arrangement) of virulent strains

    Pathogenic Mycobacterium spp.

    BCG

    AIDS
    patients

    Mycobacterial Clinical Syndromes

    Diagram
    of a
    Granuloma
    NOTE: ultimately a
    fibrin layer develops
    around granuloma
    (fibrosis), further
    walling off the
    lesion.
    Typical progression
    in pulmonary TB
    involves caseation,
    calcification and
    cavity formation.

    Laboratory Diagnosis of
    Mycobacterial Disease

    Nucleic acid probes


    Nucleic acid sequencing

    Mycobacterium leprae

    Mycobacterium leprae Infections

    Mycobacterium leprae Infections (cont.)

    Tuberculoid vs. Lepromatous Leprosy


    Clinical Manifestations and Immunogenicity

    Lepromatous vs. Tuberculoid Leprosy

    Lepromatous Leprosy (Early/Late Stages)

    Lepromatous Leprosy Preand Post-Treatment

    Clinical Progression of Leprosy

    Effect of Cell-Mediated Immunity on


    Leprosy Clinical Outcome

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