1.

Recall the cells

of the immune
system.

2. To illustrate
the life history of
B cell.

3. To demonstrate the
stages in the
developmental process
of B cell maturation

B cell Maturation

Bone Marrow
IG Rearrangements
Pre B Cell Receptor
Selection of Immature Self Reactive B cells
Negative Selection
Rescue Editing of Light chain genes

B Cell Activation &

Proliferation

T dependent and T independent antigens

Origins of activating signals
Transduction of activating signals
B cell co-receptor complex
T helper cells
Formation of T-B conjugate
Mediation by CD-40
Induction of Progression signals
Negative Selection

B cell Activation

B cell Activation
Thymus-dependent (TD) antigens
B cell required direct contact with TH cell
B-2 B cells, majority of B cells
Thymus-independent antigens (TI)
These antigens activate B cells by pattern
recognition receptors (bacteria that might be in
high amount)
Type I (TI-1) lipopolysaccharide
Type 2 (TI-2) highly repititous molecules (bacterial
flagella)

B cell differentiation
Affinity Maturation
Somatic Hyper mutation
Antigen selection

Class switching
Plasma cells
Memory cells

4. Criticize the factors

involved in the B cell
development and
maturation.

Regulation

Humoral and cell-mediated branches must be heavily

regulated
Cytokines play important role
Antigenic competition
Previous encounter with antigen can render animal
tolerant or may result in formation of memory cells
Presence of antibody can suppress response to antigen
Some vaccines are given to babies after maternal IgG
(that was transferred across placenta) has left system
Vaccination before this will prevent proper response
and development of long-lasting memory cells

References
Thomas J. Kindt, Barbara A. Osborne and Richard
A. Goldsby, Kuby Immunology, W.H.
Freeman &
Company, 2006.
Melchers F and Rolink A, B-Lymphocyte
Development and Biology, Fundamental
Immunology, 4th Edition, Lippincott-Raven
Publishers, 1999