Kawasaki Disease

Luis A.Terron (MS4)

Foreword
Disease of unknown origin
Medium size vessel vasculitis
characterized by:
Fever
Swelling
Rash
Irritation of eyes and
mouth
Affects young children

Foreword
Other names:
Kawasaki Syndrome
Mucocutaneous Lymph
Node Syndrome
Named after Tomisaku
Kawasaki
1967

INTRODUCTION

Epidemiology

More active in winter

US 4000 per year
80% < 5 y/o
+ Comon in Boys than girls
Rarely > 8y/o

SIGNS AND SYMPTOMS

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Conjuntival Injection

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Strawberry tongue

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Swollen lips

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Erythematous rash perineum

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Erythematous rash perineum

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Edema of dorsa of hand

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Erythema of hands

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Erythema of feet

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Descamation of fingers

Click icon to add pictureCervical lymphadenopathy

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Sings
(A) Bilateral "conjunctival injection". (B)
Strawberry tongue and bright red, swollen lips with
vertical cracking and bleeding. (C) Erythematous rash
involving perineum. (D) Erythema of the palms, which
is often accompanied by painful, edema of the dorsa
of the hands. (E) Erythema of the soles, and swelling
dorsa of the feet. (F) Desquamation of the fingers. (G)
Erythema and induration at the site of a previous
vaccination with Bacillus Calmette-Gurin (BCG). (H)
Perianal erythematous desquamation.

COMPLICATIONS

Most feared complications

Myocarditis
Pericarditis
Arrythmia
Mithral valve problems
Coronary inflammation
Coronary aneurysm
Death 1%

Diferencial diagnosis
Rocky Mountain Spoted
Fever
Measles
Alergic Drug Reactions
Scarlet Fever
Juvenile Rheumatic Arthritis

Labs
CRP
ESR
CBC

Treatment

Aspirin
Intravenous gamaglobulin
Corticosteroids
TNF blockers
Plasmaphoresis

GRACIAS