Small water

soluble solutes
< 500 d
Asymmetric
dimethylarginine
Benzylalcohol
-Guanidinopropionic
acid
Cytidine
Creatinine
Guanidinosuccinic acid
-Lipotropin
Guanidine
Guanidinoacetic acid
Hypoxanthine
Malondialdehyde
Methylguanidine
Myoinositol
Orotic acid
Orotidine
Oxalate
Pseudouridine
Symmetric
dimethylarginine
Urea
Uric acid
Xanthine

Protein-bound
solutes
< 500 d
3-Deoxyglucosone
carboxy-methyl-propylfuranpropionic acid
Fructoselysine
Homocysteine
Hippuric acid
Indoxyl sulfate
Glyoxal
Hydroquinone
Indole-3-acetic acid
Kinurenine
Kynurenic acid
Methylglyoxal
N-carboxymethyllysine
P-cresol
Pentosidine
Phenol
P-OHhippuric acid
Quinolinic acid
Spermidine
Spermine

Middle molecules
> 500 d
Adrenomedullin
Atrial natriuretic peptide
2-Microglobulin
Clara cell protein
Cholecystokinin
Degranulation inhibiting
protein I
-Endorphin
Complement factor D
Cystatin C
Delta-sleep-inducing
peptide
Endothelin
Hyaluronic acid
Interleukin 1
Interleukin 6
Kappa-Ig light chain
Lambda-Ig light chain
Leptin
Methionine-enkephalin
Neuropeptide Y
Parathyroid hormone
Retinol binding protein
Tumor necrosis factor alpha

Vanholder R. et al New insights in uremic toxins. Kidney Int. (2003) 63; 84: S6S10