Benzathine penicillin G secara intra muskular alergi? doksisiklin 100 mg per
oral 2x sehari selama 14 hari atau tetrasiklin 500 mg per oral 4x sehari selama 14 hari. Sumber: Rolfs R.T., Joesoef M.R., Hendershot E.F.,1997., The Syphilis and HIV Study Group, A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection, N Engl J Med;337:30714.