Pertemuan Ilmiah Tahunan Perdami ke-40

Animal Models in Glaucoma

Nurwasis MD, Dept. Of Ophthalmology, Dr. Soetomo Hospital/
Faculty of Medicine Airlangga University, Surabaya
Abstract
Glaucoma is a progressive neurodegenerative disorder that affects
the retinal ganglion cells and their axons. Increased intraocular pressure is
a major risk factor in the disease.
Acute and chronic elevation of intraocular pressure specifically
induced the death of retinal ganglion cells. The therapeutic control of IOP
in many patients is not sufficient to arrest the progression of the disease
process. However, the basic neural and cellular

pathophysiology that

cause the characteristics sign of glaucoma can not be studies in clinical

patients.
Animal models faithfully replicate important aspects of the condition
in order to understand disease mechanisms and to develop new therapies.
In choosing animal models, several factors are usually considered:
anatomy of vascular circulation and retina, relevance to humans disease,
sample size and cost, easier to produce and handle. Rats are most widely
used in glaucoma models.
By developing animal models of the disease, the scientific
community has been able to make progress in understanding the cellular
and molecular mechanisms leading to death of retinal ganglion cells.
This review is an effort to summarize the current concept in the
pathophysiology of glaucoma.

Trans Luxury Hotel

Bandung, 13-15 Agustus 2015