2 (type 2 diabetes)

insulin

glucose (oral
hypoglycemic drugs)
1. sulfonylureas tolbutamide, glyburide

insulin

ATP-sensitive K+ channels (KATP

channels) cells K+
depolarization
Ca2+ voltage-dependent
Ca2+ channels Ca2+

cells insulin
exocytosis

 1
sulfonylureas
(: http://www.clinicalcorrelations.org/?p=500
[Accessed 2013 Aug 28])
2. biguanides metformin
insulin

1. gluconeogenesis
enzyme phosphoenolpyruvate oxidase
glucose-6-phosphatase
2. GLUT4 (Glucose transporter type 4)


3. glucose

2
biguanides
(:
http://www.medscape.com/viewarticle/745721_6
[Accessed 2013 Aug 28])

 3 uptake glucose
GLUT-4
(:
http://commons.wikimedia.org/wiki/File:Insulin_gl
ucose_metabolism.jpg [Accessed 2013 Aug 28])
3.
exenatide
analogue
GLP-1 (glucagon-like peptide) GLP-1
incretin hormones

glucose
insulin

exenatide agonist GLP-1 receptors


incretin GLP-1 receptors
cells GS protein coupled
receptors cAMP Ca2+
insulin
GLP-1 receptors cells

hormones glucagon
glucose

4
GLP-1

(:
http://www.sciencedirect.com/science/article/pii/S
1550413106000283 [Accessed 2013 Aug 28])

Reference
. (2552).
. : .