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  • Mutation: Universal

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    A mutation is a change in a gene's nucleotide sequence that may alter the resulting polypeptide. DNA controls cell activities through proteins, as DNA codes for enzymes and proteins that control what other proteins are made. A small mutation in the gene coding for beta-globin in hemoglobin causes sickle cell anemia, where the codon CTT, which normally codes for glutamic acid, is substituted for CAT, coding for valine instead.

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    A mutation is a change in a gene's nucleotide sequence that may alter the resulting polypeptide. DNA controls cell activities through proteins, as DNA codes for enzymes and proteins that control what other proteins are made. A small mutation in the gene coding for beta-globin in hemoglobin causes sickle cell anemia, where the codon CTT, which normally codes for glutamic acid, is substituted for CAT, coding for valine instead.

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    27 views1 page

    Mutation: Universal

    Uploaded by

    api-296833859
    A mutation is a change in a gene's nucleotide sequence that may alter the resulting polypeptide. DNA controls cell activities through proteins, as DNA codes for enzymes and proteins that control what other proteins are made. A small mutation in the gene coding for beta-globin in hemoglobin causes sickle cell anemia, where the codon CTT, which normally codes for glutamic acid, is substituted for CAT, coding for valine instead.

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    Genes and Mutations

    Mutation: A change in the nucleotide sequence of a gene which may then result in an altered
    polypeptide.
    A very small percentage of DNA actually codes for a protein. The function of the remainder of
    DNA is uncertain.
    DNA controls all the activities of the cell because these activities are controlled by enzymes
    (proteins) and DNA is a code for proteins. Thus, DNA controls what proteins (enzymes) are
    made.
    A group of three bases code for an amino acid, so DNA has a triplet code.
    - This genetic code is universal.
    Sickle cell anaemia:
    - The gene which codes for the beta-globin in haemoglobin has a mutation.
    - The normal allele, HbA of haemoglobin contains the codon CTT coding for glutamic acid.
    - In the allele which causes sickle cell anaemia (HbS) a mutation called a substitution occurs
    and the CTT codon is replaced by CAT which codes for valine.

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