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    The document summarizes the isolation of α-mangostin and β-mangostin compounds from the fruit hull of Garcinia mangostana Linn. and testing of α-mangostin for antidiabetic effects. α-Mangostin and β-mangostin were isolated from n-hexane extracts, and a flavan derivative was isolated from acetone extracts. Structure determination was done using spectroscopy. Antidiabetic assays on alloxan-induced rats found that α-mangostin at a dose of 10 mg/kg was the most effective, showing potential as a new antidiabetic drug. Its antidiabetic activity is related to its antioxidant

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    alfa mangostin antidiabetes

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    1410201002-abstract_id

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    The document summarizes the isolation of α-mangostin and β-mangostin compounds from the fruit hull of Garcinia mangostana Linn. and testing of α-mangostin for antidiabetic effects. α-Mangostin and β-mangostin were isolated from n-hexane extracts, and a flavan derivative was isolated from acetone extracts. Structure determination was done using spectroscopy. Antidiabetic assays on alloxan-induced rats found that α-mangostin at a dose of 10 mg/kg was the most effective, showing potential as a new antidiabetic drug. Its antidiabetic activity is related to its antioxidant

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    © All Rights Reserved
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    11 views1 page

    1410201002-Abstract Id

    Uploaded by

    devaunusa
    The document summarizes the isolation of α-mangostin and β-mangostin compounds from the fruit hull of Garcinia mangostana Linn. and testing of α-mangostin for antidiabetic effects. α-Mangostin and β-mangostin were isolated from n-hexane extracts, and a flavan derivative was isolated from acetone extracts. Structure determination was done using spectroscopy. Antidiabetic assays on alloxan-induced rats found that α-mangostin at a dose of 10 mg/kg was the most effective, showing potential as a new antidiabetic drug. Its antidiabetic activity is related to its antioxidant

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    © All Rights Reserved
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    of 1

    Isolation of Mangostin and Flavan Compound and Antidiabetic

    Assay of -Mangostin Compound from Fruit Hull of Garcinia


    mangostana Linn.
    By
    : Devyana Dyah Wulandari
    Student Identity Number : 1410 201 002
    Supervisor
    : Prof. Dr. Taslim Ersam

    ABSTRACT
    -Mangostin compound (1,3,6-trihydroxy-7-methoxy-2,8-di (3-methyl-2butenyl) xanthone) and -mangostin compound (1,3,6,7-tetrahydroxy-2,8-di(3methyl-2-butenyl) xanthone) (2) was isolated from n-hexane extracts and flavane
    derivative (5,7,2,4-tetrahidroksi-flavan-3-ol) (3) from acetone extract of the fruit
    hull of G. mangostana by extraction, partition, chromatography and crystallization
    method. Structure determination was carried out using spectroscopic data UV, IR, 1HNMR, 13C-NMR, 2D NMR, HMBC and HMQC. Antidiabetic assay was investigated
    using male Wistar rats induced by alloxan dihydrate showed compound -mangostin
    have the most effective dose of 10 mg / kg, so these compounds potential to be new
    antidiabetic drugs. Activity of -Mangostin compounds as antidiabetic closely related
    to its activity as an antioxidant.

    Key words: Garcinia mangostana Linn., xanthone, antidiabetic.


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