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Dengue: Divya Bappanad Karapitya Hospital Galle, Sri Lanka
Dengue: Divya Bappanad Karapitya Hospital Galle, Sri Lanka
Divya Bappanad
Karapitya Hospital
Galle, Sri Lanka
Initial Presentation
HPI: 18 yo Sri Lankan male in USOH until
developed fever, myalgias and vomiting x 3 days.
On basketball team and day prior to fever
participated in game with no complaints.
PMH: none
Medications: none
Immunizations: up to date
SH: student, lives with mother in nearby
community outside Galle, + electricity and
running water, no siblings, no recent travel.
Physical Exam
Vitals: T 40C BP 110/80 supine 90/70 standing
HR 96 RR 16 SpO2 not available
Gen: Alert, Ill appearing
HEENT: PERRLA, EOMI, + conjunctival
injection, OP clear, MM dry
Neck: No LAD
CV: RRR, no m/g/r
Lungs: CTAB, no w/r/r
Ab: +BS, soft, NT, ND, no HSM
Ext: No edema
Skin: No petechia
Studies
WBC 5.2 86% N, 12% L and 1.2% M, Hgb 14 and
Platelets 16,000
Dengue IgM + and IgG +
CXR: clear
Progressive Deterioration
Day 6 Abdominal compartment syndrome
Paracentesis with 1.5 L removed
Dengue Epidemiology
Incidence
Dengue virus
Epidemiology
Vector
Mosquito
Primarily Aedes Aegypti
Aedes albopictus, Aedes polynesiensis and other
Aedes species also
Clinical Progression
Critical phase
3-7 days
Temperature defervescence with possible
increased capillary permeability and increasing
hematocrit
If no change in capillary permeability will improve
and non-severe dengue
If fail to defervesce and develop leakage
concerning for development shock
Clinical Progression
Recovery phase
2-3 days
Reabsorption of extravascular fluid
Bradycardia and ECG changes common
Hemodynamics stabilize, auto diuresis begins and
patient clinically improves
Diagnosis
Clinical diagnosis
Live and travel in endemic area and fever + 2
Serologic Diagnosis
Decreasing wbc
1st serologic abnormality
Treatment
Supportive
WHO management algorithm for fluid
resuscitation
Transfusion
Oxygen
ICU monitering
Prognosis
Dengue fever < 1% mortality
Dengue hemorrhagic fever approx 2.5%
mortality
Primarily children
Recurrent infection
Active infection protected from illness from
different serotype for 2-3 months, but not long
term
Infection by one serotype confirms lifelong
immunity to that serotype
No immunization currently available
Bibliography
Dengue: guidelines for diagnosis, treatment, prevention and
control. Second edition. Geneva: World Health Organization. 2009.
Accessed at
http://whqlibdoc.who.int/publications/2009/9789241547871_eng.
pdf
Singhi S, Kissoon N, Bansal A. Dengue and dengue hemorrhagic
fever: management issues in an intensive care unit. J Pediatr (Rio
J). 2007; 83(2 Suppl):S22-35.