ACKNOWLEDGMENTS

We are grateful to all the contributors for their expertise, careful writing and updating, and timeliness in submitting their chapters. We feel fortunate to learn from the foremost authorities in
the field of hepatology. We particularly appreciate the support and counsel of Druanne Martin
and Kate Dimock, our acquisitions editors, and Kate Crowley, our editorial assistant, at Elsevier
Saunders, without whom this edition would not have been possible. We thank our friend and
mentor, Jules Dienstag, for his eloquent foreword. We also appreciate the work of the fellows
in gastroenterology and hepatology at Stanford University School of Medicine, who prepared
review questions for this edition, and our assistants, Alison Sholock and Karen Ely, who helped
keep us organized. Finally, we are eternally grateful to our families for their unfailing support
during the preparation of this third edition.

SPECIAL TRIBUTE
Sadly, Emmet Keeffe passed away unexpectedly just as the third edition of Handbook of Liver
Disease was published. Emmet had been as excited about the release of the third edition, and as
proud of it, as he had of the previous two editions. Emmet had worked tirelessly on the book
and was a marvelous editor. He had a remarkable mastery of the breadth of hepatology, a talent
for clear, organized, and informative exposition, and an impressive feel for what was important
to practitioners and to patients. He always dealt with authors in a direct yet respectful manner
and loved to discuss the ins and outs of liver disease and the finer points of English grammar. We
shared a passion for medicine and scholarship.
Emmet had a remarkably successful and productive academic career, but he will be most remembered as a loving and devoted husband, father, and grandfather, a compassionate and effective physician, and a warm and generous person with whom everyone felt comfortable and with no hint of
pretense or formality. Emmets professional life was a reflection of his love of humanity, dedication
to the service of others, and devotion to the generation and communication of new knowledge.
Emmet was a consummate quadruple-threat academician with strengths as a clinician, clinical investigator, educator, and administrator. His contributions spanned the breadth of gastroenterology and hepatology, from flexible sigmoidoscopy to liver transplantation, and he brought
enlightenment to numerous areas. His particular interest was in the treatment and prevention of
viral hepatitis. Emmet helped develop and lead three successful liver transplantation programat
Oregon Health and Science University, California Pacific Medical Center, and Stanford Medical
Center. He held numerous leadership and editorial positions, including service as president of the
American Society for Gastrointestinal Endoscopy from 1995 to 1996 and president of the American Gastroenterological Association from 2004 to 2005. He also served as chair of the American
Board of Internal Medicine (ABIM), Subspecialty of Gastroenterology and as a member of the
ABIM Board of Directors in 2007. In addition to serving as co-editor of Handbook of Liver Disease,
Emmet was editor-in-chief of the journal Digestive Diseases and Sciences at the time of his death.
Emmet had numerous friends around the world, many of whom have eulogized him for his
warmth, compassion, empathy, work ethic, integrity, grace, and wisdom. He was a natural leader
who led by example and consensus-building and was generous in his praise of others, yet always
humble about his own accomplishments, which were prodigious. He was an international ambassador of gastroenterology and hepatology and truly beloved by all who knew him. Handbook of
Liver Disease is but one of countless legacies of this giant of Medicine.
Lawrence S. Friedman, MD
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