Pathophysiology of J.S.

21 years old with Diagnosis of Sepsis s/t AGE

Predisposing Factors:
Age
Sex
Congenital Anomaly:
Hirschsprungs Disease
Maintains proper GI Function
through an ostomy
Previous multiple GI surgeries

Predisposing Factors:
Diet
Sedentary Lifestyle
- Previous meal (kwekkwek, tinolang manok
etc. )

Susceptibility towards
waterborne or foodborne
contamination
Pathogen enters GI tract

Metronidazol
e

Stimulation of inflammatory response

Ceftriaxone

Release of endotoxins
Stimulation of
mucosal lining
of the intestine

Metoclopromi
de

Increased secretion of
water and electrolytes
into intestinal lumen

Increased secretion of
chloride and bicarbonate
ions
Release of proteins and
fluids in the bowel

Overwhelming of large
intestines ability to
reabsorb fluids

Inhibition of sodium
reabsorption

Diarrhea

Pathogen
infiltration in
the blood

Invitation and
destruction of
mucosal lining

Irritation of intestinal mucosa

Nausea/
vomiting

Abdomin
al pain

Decreased
circulating
volume

RC: Sepsis

High WBC
and
neutrophils

Altered digestion and

Decreased
cardiac output

Decreased
renal
perfusion

Hypotension

High BUN
and
Creatinine

Dehydration
Decreased
Deficient Fluid
Volume

Plain Lactated
Ringers

Decreased
urine output

AKI s/t shock