Group 5

SUNU PERTIWI
DYAH RETNO
PERSONA GEMILANG
SURYADI

B1B015007
B1B015011
B1B015022
B1B015023

Beta Oxidation Part I

The break down of a fatty acid to acetyl-CoA
unitsthe glycolysis of fatty acids
STRICTLY AEROBIC

Occurs in the mitochondria

Acetyl-CoA is fed directly into the Krebs cycle

Overproduction causes KETOSIS

Exemplifies Aerobic Metabolism
at its most powerful phase

 Bioenergetics is an energy transformations

within living organisms, and the efficiency
of energy transfers between different
organisms.
Beta Oxidation 2 C fat compound Stearic
acid is an 18 C fat yields 147 ATP

CH3CH2CH2COOH
ATP
PPi
[CH3CH2CH2CO-AMP]
HS-CoA
AMP

Fatty acyl
CoA Ligase

CH3CH2CH2CO~SCoA
Fatty acyl CoA

Prepares a Fatty Acid for transport and metabolism

Transport into Mitochondria depends on Carnitine

+

FA~CoA

Acyl transferase I

HS-CoA
FA~Carnitine

Carnitine

N(CH3)3
CH2
H-C-OH
CH2

Translocase
FA~Carnitine
HS-CoA
FA~CoA

Carnitine
Acyl transferase II

COOCarnitine

B E TA O X ID A TIO N

C H2C H2C H2C OO

H
C H2 C
H
H

C H2 C

C H2C H2C OO
H

C
COO
H

C
COO
H
H H

C H2 C C
C OO
HO H
H

C H2 C C
C OO
O H

MECHANISM
Round

CH3CH2CH2CH2CH2CH2CH2C~S-CoA
Cofactor or Substrate
O
H
Dehydrogenase -C=C-C~S-CoA
FAD
H O
TRANS
HO
Hydratase
-C- CH2-C~S-CoA
H2O
H
LO
Dehydrogenase
Acyl
Transferase

-C- CH2-C~S-CoA
O
O
R -C...CH3-C~S-CoA
O
O
S-CoA

NAD+

HS-CoA

THE ENERGY STORY

PART I
Glucose
C6H12O6 + 6O2 6CO2 + 6H2O Ho = -2,813 kJ/mol
= - 672 Cal/mol
= 3.74 Cal/gram
Stearic Acid
C18H36O2 + 26O2 18CO2 + 18 H2O

Ho = -11,441 kJ/mol
= - 2,737 Cal/mol
= 9.64 Cal/gram

On a per mole basis a typical fatty acid is

4 times more energy rich that a typical hexose

Energy Story Part II

1.0 g glucose = 3.7 kcal (15.5 kJ)
1.0 g stearic acid = 9.7 kcal (40.5 kJ)
ENERGY CONSERVATION
Stearic Acid (C18 satd)

Textbook

9 Acetyl CoA
8 FADH2

= 108 ATP
= 16 ATP

(90)
(24)

8 NADH

= 24 ATP

(20)

= 148 ATP
- 1 ATP

(134)
-1

147 ATP

(133)

THANK YOU