!

" # $
% & & '
( ) ( * + , - . / 0 1 *
+-/1 ( 2
3& ( 4 56 " $ % & ( + 7 $ (
# * $ / $ % & * $/&89 ( ( :;
( < 2 * # $ / 5 1
5 )') *#/$/ & ): % .6 # =+5$> &+ ? :; =
+ 7 $ ( # < + 7 $ ( + $ @ 8 ) ?
$ % & 8?$& 8 ) = = ' 85=/ *
% 4 8 ) &; + 8&+ 8 ) + % + '
* &( ? :; 9 A :; = ?819 = + 6
B ) ) 5 6; & +5CB 85> &89"$& D 5= $ "5/E >=$C"
F2 #
C & ' ) ( G ) ( ) H . 2 0
7
) 7 :H + +I
( ) :; & # < + 6 = ( )
( 0
7 + ( 7 ( ) ( < H
) J + 6 = 6 ( < ( 70 H
@ ( ( ( :; & # < + 6
= ( *
+-/1 % ( < ( C 6 ! :; 1 :H 8 ( :;
= 81 &=C
" ;
G ) 7 ) ( @
7 ( ) :; ) ! :; & # < ( 6
' 6 F .
 / :;
) :; K
" = :; 5 (I ? ) # < + , =
# ; ( ; ( ( 0
"
( 4" 7 G 6 ) :H
( ' 7 ' ( @ )
( ') + +I )L
" * , + - . / 0 1 *+-/1 < 7
0 ( B M D N ( 9 D N
! 9 D ) $ 2
= B O M> M < 7 7 *+-/1 ( 6
7 ! ( ) ( < + , = #
F :; ( 0 ( ) :; ( :; ( :; + , P
! $ 2 = L
" = ; # &0 % .6 + .6 &* % + < 7
( P J # < ) J 6 6 6 .6
( .6 < ( ! :; ( 6 .6 " @)
6 6 L
" = 74 1 :H 8 ( $ / B ) ) <
6 "$ /6 (
) ) " ') @ " L
" B :; B J$ . < (0
81 &=C @ ( ( :; ( :; @ : 6 .6 (
:; =4 L
" B ; 81 &=C ! "# $%$% < "
) 7: ( :; ( :; @ . 6 .6 L
" :; ( 81 &=C & M <
@ : 6 .6 G ( :; 6 26 7
) ) , ') . L
" < ) ( 81 &=C 5 ) # 7 + ,
- % ( < ( ( ) 6 ( < 26 ( ) :;
( , ) ) :; , L
" = # 62 < 7 ( 6
( ) 6 :; :;
7 < + , = L
" 6 ) 7
0 < # < "
< < @0 J F :;
( ( (' ) < ) 6
) 6 .F :; ( 6
( ( ( ) 0 ( G L
" < # < "
( 6 ) ! ( ( ( F( :;
"7! 0
6 J 4 @ ) ( :;
< ! ( <Q4 7: 7 F( )
, < 7: " 7 4F :; J ( 7
6; L
" 6 ) < ) .6 # < 2
:; :; @ ( F( ; 7
60 ( :; (2 F. ( ( ( ( '
0
6 L

/& # < I G 0( 7 :H 6 .6 @0 '

( .6 < .6 @ . F ' 0
7 !
< @ 7 :H ( ) 6 &
( 81 &=C M C G ) ) 6 @
 2 ( ) :; ) :; 6 .6 ( .6 <
@ 7 :; F 4 7 ) ( 2
8 % ( < " )P % (
( < ) :; 6 .6 6; < G (H )
.6 < .6 ( .6 @ . ! /(
:; 7 0 7 ) ( ) ) ')
) 6 :; @ ( ) :; & @ ; 7
6 G 0 ) :; ( ) G (
; ( ( ( :H
C< 6; & # < ( P 6 ( 0 ) )
% ( < 2 ( P @ ' <Q 7 :;
) '6 0( < ) ) G 7 :H '
@ 7 2 I ' 0 (
:; / 7 :; ' < 7 1 ( !.
+ 0 76 2 6 6 .6 :
( < ( ( ) (. 6
: < ( :; ) 7 :; 7 0 ; )
F( ; =
/ ( : @ ' ) (
4 7 07 G ) + !. 2 + 1
6 !' / 2 & 2 6 7 ) ) 7
.
67 ( 4
/ # < " ( :; 5 ) # 7
5 ) # 7 + 5 ) # 7 $ /P <
2 ( #
+ !H . # < ) G :;
6 07 ) P K
"2 ! ( 2 6 I 8 = ) :; 6 7
$ % & + < 1 & # <
< ) ) 0( # # < E + $ @
( 7! M @ L
" 7 :H " )6 *+-/1K
6 9 6 /! 1 & @ /( ) F ( )
( 60 4 0
7 :; M 9) /< .6 6 '7
+ 60 + D " " L
" 6 9 6 /! 1 & @ /( ; $
1 ( B D N ML
" # < " &*% + = ; # &0
% .6 + .6 &0 D NMR ' ( # G
( < ( ( :H ( ' ( @ .6 7
( ) :; L
" F ) 5 ) + + , 1 5++1 6;
# < ( ) .6 L
" 6; # < 2( ( ( )
() 0
6 < S T ' S A2
I ( 2 :; % ( :
( :; ( :; . L
" # < ) 0 < .6 ( 2"@ .
@ . < ( . % + 6 5
96 B F2 # ) 7 ) 7! @
( ( ( ( ! :; 6 @ 0 ) "
L
" 6; 7 " ) ( ( :; <
' @

!" ! # $!
 + 6 6 ( < I P ! ( J ( <
J ) !< ( ) :; ( ) :; J
@ 7 @ ( 6
+ ( 0 7
0 .(
.6 # < ) G :; ( ( (
(I ) 0
( 8 ; )
( ! 6 K

%& C (, 7 07 2 6 ') ( 7
) ( 2 ( 0 ( :; @ ) :; .6
( <Q @ / " ( )
( ) :; ( *+-/1 (. 7 0
7 < ( 0 ( .6
@ ) :H < (
) ) :H ( :; 7 ! :; ( :; ( , =
*
+-/1 2 6 64 ) ) :H ) J6 :;
( :; 6 ( ( ) :; ( ,
( .6 7 @ F ( ( 0 )

'& 8 ( 0 7 ! ) :; ( ) :; ( , (
% ( < + 6 = # < ) ' ) :;
( :; 7: ) ( 6 P 7 K (
7 B) ' ( 7 ! :; "
7 7 ' ( ( 0 ( ) :;

( & /( 0 ) :; ( ) :; ) J+ 6 = % ( <
# < ) ' 'F 6 :; I (
) ) 6 ! :H ; "6 ) )
( < 0 ' ( <
( P # < G @ 6 ( ! ( (6
:H ( (I ! , 6;

)& /) :; ( ( 6 ( < ) ' ) 6 :; @

0
7 ( :; (

*& C% ( < ) ' :; F (

( :; ) FH ( 0) 7 )
+ , < .6 ( .6 6 .6 @ .
:; ); ( ( ( :H ( F( 4

+& / :; # < ( $ /P
# ) ' (:; :; ( 6 ( <

,& /( : 0 @ . ) ( . 5 96
% + 6 ( : 0
6 ( ) 0 < .6 6;
# < ) ; ) :; ( < :;
+ 6 = ( 0
) 6 ( ( 6 ( <

-& B 7 ' ( & 1 8

= ) :; &18= < < ( ( :; J ( :; 6
( :; ) , % ( < G6 7F ( ) :;
) ( :; ) ! :; ( 6
6; 0 ) ; 7 ! ( ( F(
( 81 &=C 6 ( < 7 ): ) ) (( :;

. & C " ) (
F( 4 @ ( ( :; < 6 :; ;
( ) :; ) ( ) , )') ( 6;
# < + @' < ( < ; ) I
7 @! :; ; ! ( < < G G ( )
B) ; G "7! 06 J 4
F( :; :; ) 2 < (

C @ ) ) # < ( 6 :H 7
( ' 6 ; J< < ( ( )
7 '" 6 : ( ( ) :; U ( ;
# < + 6 = # 7 % ( <
76 " < :; :H (
( 7 - 1 ! ( I 7 ) ( :;
@ .

# ) + )