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  • Oral Glucose Suppression Test

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    Emmanuel Jason Fabi
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    The oral glucose tolerance test is used to diagnose acromegaly and determine remission after pituitary surgery. Patients fast for 8 hours before drinking 100g of glucola over 5 minutes. Serum glucose and growth hormone levels are measured at baseline and every 30 minutes for 2 hours. In normal individuals, growth hormone levels suppress below 2 mg/ml after glucose ingestion, while levels remaining above this threshold could indicate acromegaly.

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    The oral glucose tolerance test is used to diagnose acromegaly and determine remission after pituitary surgery. Patients fast for 8 hours before drinking 100g of glucola over 5 minutes. Serum glucose and growth hormone levels are measured at baseline and every 30 minutes for 2 hours. In normal individuals, growth hormone levels suppress below 2 mg/ml after glucose ingestion, while levels remaining above this threshold could indicate acromegaly.

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    5 views1 page

    Oral Glucose Suppression Test

    Uploaded by

    Emmanuel Jason Fabi
    The oral glucose tolerance test is used to diagnose acromegaly and determine remission after pituitary surgery. Patients fast for 8 hours before drinking 100g of glucola over 5 minutes. Serum glucose and growth hormone levels are measured at baseline and every 30 minutes for 2 hours. In normal individuals, growth hormone levels suppress below 2 mg/ml after glucose ingestion, while levels remaining above this threshold could indicate acromegaly.

    Copyright:

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    ORAL GLUCOSE SUPPRESSION TEST

    Indication
    The oral glucose tolerance test is used for the diagnosis of acromegaly and to
    determine the status of remission after pituitary surgery. In normal
    individuals, hyperglycemia suppresses growth hormone secretion.

    Preparation
    NPO for at least 8 hours prior to suppression test.

    Procedure
    1. Baseline serum growth hormone, somatomedin-C and glucose levels
    2. Administer 100 g of glucola orally over 5 minutes
    3. Serum glucose and growth hormone levels at 30, 60, 90 and 120 minutes

    Interpretation
    In normal individuals, growth hormone suppresses below 2 mg/ml after
    ingesting 100g of glucola. More sensitive assays require a growth hormone
    level below 1 mg/ml to rule out acromegaly. False positive results can occur
    in patients with diabetes mellitus. anorexia, liver failure, tall adolescents,
    and individuals with growth hormone resistance disorders.

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