Chemotherapy Charts-MBBS V SEM

K.M.C.Mangalore

1. Metronidazole:
Name a clinical condition for its I.V. use
Post op. Intra abdominal surgery against G-ve infections [Colorectal, pelvic, appendicectomy].
Severe amoebic hepatitis
2. Linezolid
Name the principal toxicity when it is administered for more than 2 weeks
Thrombocytopenia-Myelosuppression
3. Mupirocin
Give one specific indication
Topical treatment for bacterial skin infections, for example, furuncle, impetigo [Staph.aureus]
Orally not effective-Converted to monic acid.
4. Gentamicin
Write the drug interaction that occurs outside the body
Gentamicin+Penicillin-Inactivates[Heparin, Amphotericin B, Cephalosporins]

5. Trichomoniasis
Mention two drugs used in this condition
Metronidazole. Clotrimazole pessaries
6. Aminoglycoside
Name one orally administered AG and its indication
Neomycin-Orally preoperative bowel preparation. In hepatic failure to prevent
encephalopathy
7. Azithromycin
Give two advantages over erythromycin
Improved PK profile-Better absorption, distribution, tissue penetration, longer duration of
action, not an CYP enzyme inhibitor
Broader spectrum [Typhoid. Malaria, Toxoplasmosis.]