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  • Pathophysiology Predisposing Factors - Genetics Precipitating Factors - Faulty Diet

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    Genetic and dietary factors can predispose individuals to cholesterol gallstone formation. Liver cells secrete cholesterol in bile vesicles, but if the bile becomes supersaturated with cholesterol due to an excess of cholesterol carrying capacity, cholesterol crystals may nucleate and form gallstones, resulting in cholelithiasis.

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    Pathophysiolog1

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    Genetic and dietary factors can predispose individuals to cholesterol gallstone formation. Liver cells secrete cholesterol in bile vesicles, but if the bile becomes supersaturated with cholesterol due to an excess of cholesterol carrying capacity, cholesterol crystals may nucleate and form gallstones, resulting in cholelithiasis.

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    51 views3 pages

    Pathophysiology Predisposing Factors - Genetics Precipitating Factors - Faulty Diet

    Uploaded by

    paulotatsukami
    Genetic and dietary factors can predispose individuals to cholesterol gallstone formation. Liver cells secrete cholesterol in bile vesicles, but if the bile becomes supersaturated with cholesterol due to an excess of cholesterol carrying capacity, cholesterol crystals may nucleate and form gallstones, resulting in cholelithiasis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
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    of 3

    Pathophysiology

    Predisposing factors Precipitating Factors


    - Genetics - Faulty diet

    Liver cells secrete cholesterol


    into bile along with phospholipids
    in the form of unilamellar vesicles

    Residue
    of
    vesicles

    Some of the
    unilamellar
    vesicles dissolve
    Formation of mixed micells

    The cholesterol carrying capacity of


    the micelles and residual vesicles is
    exceed

    Bile is supersaturated
    with cholesterol

    Formation of crystas
    Nucleation of cholesterol crystals

    Cholesterol gallstone

    CHOLELITHIASIS

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