Cell Cycle

RNA, Protein Mitosis, Cytokinesis

Lamin
H1
Abl
Cyc B/A G2 M Cyc D’s G0
CDK1 3-4 h 1 h CDK4,6
G1
DNA, RNA, S
Protein 6-12 h RNA, Protein
6-8 h
p53
Cyc A Cyc E pRb
CDK2 CDK2
Eric Niederhoffer
SIU-SOM
 Variation in Cell Cycle Cyclins
Cyclin-dependent kinases
Cdk4 Cdk2 Cdk1

cyclins D E A B(A)

M G1 S G2 M G1

Start
Cell cycle phases
 Cell Cycle Regulation
1. CDK phosphorylation DNA damage

2. C degradation
Active p53
3. C & CDK synthesis

4. CDK inhibition CDK2

CE p21

P
pRb

pRb
Enzymes for Passage from
E2F DNA synthesis G1 to S
 Review Questions

What are and what happens during the phases
of the cell cycle?

Which proteins are involved in the regulation
of the cell cycle?

Which cyclins and cyclin-dependent kinases
are most important in individual phases of the
cell cycle?

What are four mechanisms for regulating
cyclin-dependent kinase activity?

What role do p53, p21, and pRb play in the G1
to S transition?