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    Laskin - Macrophages Chemical Toxicity

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    HawkNo1
    This document summarizes two main types of activated macrophages: M1 and M2 macrophages. M1 macrophages are classically activated and promote inflammatory responses through the release of pro-inflammatory cytokines and chemokines. They also express MHC class II and present antigens to T cells to promote Th1 cell-mediated immunity. In contrast, M2 macrophages are alternatively activated and promote wound healing through the release of anti-inflammatory cytokines like IL-10 and TGF-beta. They also express scavenger receptors and arginase and are involved in tissue remodeling, repair, and immunosuppression.

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    Laskin - Macrophages Chemical Toxicity

    Uploaded by

    HawkNo1
    11 views3 pages
    This document summarizes two main types of activated macrophages: M1 and M2 macrophages. M1 macrophages are classically activated and promote inflammatory responses through the release of pro-inflammatory cytokines and chemokines. They also express MHC class II and present antigens to T cells to promote Th1 cell-mediated immunity. In contrast, M2 macrophages are alternatively activated and promote wound healing through the release of anti-inflammatory cytokines like IL-10 and TGF-beta. They also express scavenger receptors and arginase and are involved in tissue remodeling, repair, and immunosuppression.

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    Laskin_Macrophages Chemical Toxicity

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    This document summarizes two main types of activated macrophages: M1 and M2 macrophages. M1 macrophages are classically activated and promote inflammatory responses through the release of pro-inflammatory cytokines and chemokines. They also express MHC class II and present antigens to T cells to promote Th1 cell-mediated immunity. In contrast, M2 macrophages are alternatively activated and promote wound healing through the release of anti-inflammatory cytokines like IL-10 and TGF-beta. They also express scavenger receptors and arginase and are involved in tissue remodeling, repair, and immunosuppression.

    Copyright:

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    Download as RTF, PDF, TXT or read online from Scribd
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    11 views3 pages

    Laskin - Macrophages Chemical Toxicity

    Uploaded by

    HawkNo1
    This document summarizes two main types of activated macrophages: M1 and M2 macrophages. M1 macrophages are classically activated and promote inflammatory responses through the release of pro-inflammatory cytokines and chemokines. They also express MHC class II and present antigens to T cells to promote Th1 cell-mediated immunity. In contrast, M2 macrophages are alternatively activated and promote wound healing through the release of anti-inflammatory cytokines like IL-10 and TGF-beta. They also express scavenger receptors and arginase and are involved in tissue remodeling, repair, and immunosuppression.

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    of 3

    Laskin

    Tabl
    e1
    Activated Macrophage Subpopulations
    Macrophage Type
    -Release pro-inflammatory cytokines (TNFα IL-1, IL-6), IL-12, IL-23, M1 chemokines
    -Express MHC-II
    -Present antigen to T cells
    -Promote Th1 responses (cell mediated immunity)
    M1 -Microbicidal activity
    Classically Activated
    -Cytotoxicity
    -Tissue injury/destruction
    -Tumor resistance
    Art
    Phenot
    ype
    A

    M2
    Alternatively Activated

    Activating Signals
    IFNγ priming followed by:
    TNFα
    GM-CSF
    LPS
    Activation of PAMP

    -
    P
    h
    a
    g
    o
    c
    Art M2a IL-4 yt
    IL-13 o
    si
    s
    -
    S
    ti
    rt
    m

    M2b Immune complexes + TLR ul


    agonists or IL-1β at
    e
    p
    r
    ol
    if
    M2c IL-10
    TGFβ er
    Glucocorticoids
    at
    io
    n
    -
    P
    r
    Chem Res Toxicol. Author manuscript; available in PMC 2010 August 17. o
    m
    ot
    e
    ti
    ss
    ue mote Th2
    repai responses
    r -Express
    Page 17
    - scavenger
    Expr receptors
    ess -Release IL-10,
    MH
    TGFβ, PDGF
    C-II
    -High levels
    -
    arginase
    Pres
    -
    ent
    Immunosuppress
    antig
    ive
    en to
    -Anti-
    T
    inflammatory
    cells
    (down regulate
    -
    M1 responses)
    Pro
    mote -Release

    Th2 extracellular

    resp matrix proteins

    onse (via TGFβ)


    s -Promote wound
    - repair, tissue
    Expr remodeling and
    ess angiogenesis
    scav -Chronic
    enge inflammation
    r
    rece
    ptors

    Micr

    obici

    dal

    activ

    ity
    -
    Phag
    ocyt
    osis
    -
    Expr
    ess
    MH
    C-II
    -
    Pres
    ent
    antig
    en to
    T
    cells
    -
    Pro
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