San Beda College

College of Nursing
Drug Study

Name/Section:_________________________________________________________________________________________________

Order: Depakene (250mg/5ml) 5ml 3 x a day

Generic Name: Valproic acid Trade Name: Depakene Available Stock: syrup 250mg/5ml
Route of Administration: oral Dosage: 10-15mg/kg/day
Drug Class Mode of Indications/ Adverse Drug Nursing Considerations Health Teachings
Action Contraindic. Reactions Interactions
Anti - Increase Indications: Asthenia, Alcohol - ↑CNS *to minimize GI irritation- *take with food or after
convulsant GABA levels For treatment of headache, Depression intiate at lower dose, give meals to minimize GI
In brain Simple or somnolence, Cimetidine - with food upset
complex dizziness, ↑pharmacologic *to minimize CNS *take only as directed and
Absence tremor, effects depression, give at do not stop abruptly
seizures insomnia bedtime
Mimic or Contra CNS: Penobarbital - *reduce starting dose in * do not drive until drug
Enhance -indications: Hyperammo- ↑effects and geriatric patients effects are realized.
Inhibitory Liver disease or nemic toxicity of * avoid alcolhol, CNS
effect of Dysfunction encephalopathy phenobarbital depressants
GABA Urea cycle *report for periodic cbc,
disorders serume glucose, and liver
Lactationa function tests
Acute *do not take if pregnant
pancreatitis
Hematologic:
hemorrhage
Arthralgia
Stevens
Johnson
syndrome
Prepared by: AMR Morelos, MD