PARKINSON’S DISEASE

Sachdev Vinay, Gnanendra Reddy and Mayuresh Puranik

Abstract Results
The treatment includes restoration of Dopamine basically through
Parkinson's disease (PD) is a chronic neurodegenerative adminsitration of Levodopa. The mechanism of action is shown in the
disease, in which mainly dopaminergic neurons in the following figure.
substantia nigra in the brain degenerate, leading to a depletion
of dopamine (DA) in the striatum. The most important motor
disturbances of the disease are bradykinesia (slowing down of
movement), hypokinesia (poverty of movement), rigidity
(muscle stiffness), tremor and postural instability. Besides
these well-known motor symptoms, non-motor symptoms
may develop, such as depression, cognitive impairment and
psychosis. Psychotic symptoms constitute a relatively common
but nevertheless serious complication, with visual
hallucinations and paranoid delusions often being most
prominent. These symptoms are important contributors to
patient and caregiver distress and are often important risk
factors for nursing home placement. Exogenous (related to
therapeutic interventions) factors are of major importance but
endogenous (related to the disease process itself ) factors
might also contribute to the development of psychotic
symptoms in PD. Therapeutic strategies comprise reduction of
antiparkinsonian treatment, cholinesterase inhibitors and
atypical antipsychotics. As psychotic symptoms in PD are
often influenced by both endogenous and exogenous factors, a
combination of strategies may be chosen. 

Introduction

Discussion

Emerging Therapies for Parkinson’s Disease

 The most common movement disorder affecting 1-2 % of the

general population over the age of 65 years.

 The second most common neurodegenerative disorder after

Alzheimer´s disease (AD).

Symptoms include

Muscle rigidity, detectable as an increased resistance inpassive

limb movement

Bradykinesia Advances in Drug Delivery for Parkinson’s Disease Therapies

Suppression of voluntary movements (hypokinesis), due partlyto

an inherent inertia of the motor system, which means that motor
activity is difficult to stop as well as to initiate.