- Age: 10 -30 yrs old - Constipation/IBD - Gender: male (2:1) - Diet (low fiber) LEGEND:
+ Bold - signs & symptoms
Fecal obstruction + Underlined - medical procedure or intervention + - not experienced by the patient Occlusion of Appendix by Fecalith
Increased ILP in the appendix
Vasocongestion Pain
Hypoxia in the appendix Pyrogens
Appendix starts to be necrotic; Bacteria invade the appendix Hypothalamus (prostaglandin production)
Disruption of Cell Membrane of Appendix Fever
Start of Inflammatory Process
Mast Cells Activation of the Vomiting Inflammation of Appendix (Appendicitis)
Center in the Medulla Appendectomy Bradykinin Prostaglandin Histamine Leukotrienes interleukin - 1 Stimulation of vagus nerve suppression of sympathetic Tissue Trauma vasoconstriction GI function
vasodilation increase WBC Nausea and vomiting anorexia
9 18.30 x 10 /L disruption of cell Nociceptors on the dermis increase permeability membrane
accumulation of WBC start of inflammatory send impulses to the CNS
to the interstitial compartment process swelling of Abdomen Phagocytosis pain, & weight loss Septic shock: pain, swelling, heat & redness swelling Exudates rupture of Peritonitis sepsis if NOT treated - decreased Blood Pressure DEATH the swelled appendix (septecemia) - decreased Blood Volume
Pain Appendectomy with If treated strong antibiotic and RECOVERY
Differentiating drug-induced dystonias, strychnine poisoning, neuroleptic malignant syndrome, stiff man syndrome, hypo-calcaemia, dental infections and more from tetanus