Autacoids I

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 Autacoids
• Synthesized at the site of action

• Exert primarily localized effects

• They are not stored and released from glands

• Autacoids (local hormones) are substances with biologic activity

• Autacoids regulate some aspects of GIT functions, uterine and

renal functions and they participate in the development of pain,

fever, inflammation, allergic reaction, asthma

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 Classification

• Biologic Amines
– Histamine

– 5-hydroxytryptamine

• Vasoactive Polypeptides
– Angiotensin

– Substance P

– Kinins

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 Classification

• Membrane derived Lipids

– Leukotrienes, Prostaglandins and Thromboxane A2
– PAF

• Endothelium derived agents

– Nitric Oxide
– Endothelins
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 Thank You

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