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  • Effects of Alcohol Intake On The Parameters of Pupil Light Reflex

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    Perdita Durango
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    The document discusses a study that evaluated the effects of alcohol intake on parameters of the pupil light reflex. Seven subjects had their pupil light reflex measured before and after consuming 500 ml of alcohol per hour using a pupillometer. The study found statistically significant differences in amplitudes and pre-stimular mydriasis after alcohol intake, with amplitudes being lower and pre-stimular mydriasis being greater. The results were not significant for different color flash stimuli. Differences were also found between values from early intakes compared to later intakes. The results indicate pupil light reflex measurements could potentially distinguish between abstemious and non-abstemious individuals and lead to new alcohol detection devices for road safety.

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    The document discusses a study that evaluated the effects of alcohol intake on parameters of the pupil light reflex. Seven subjects had their pupil light reflex measured before and after consuming 500 ml of alcohol per hour using a pupillometer. The study found statistically significant differences in amplitudes and pre-stimular mydriasis after alcohol intake, with amplitudes being lower and pre-stimular mydriasis being greater. The results were not significant for different color flash stimuli. Differences were also found between values from early intakes compared to later intakes. The results indicate pupil light reflex measurements could potentially distinguish between abstemious and non-abstemious individuals and lead to new alcohol detection devices for road safety.

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    Attribution Non-Commercial (BY-NC)
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    39 views1 page

    Effects of Alcohol Intake On The Parameters of Pupil Light Reflex

    Uploaded by

    Perdita Durango
    The document discusses a study that evaluated the effects of alcohol intake on parameters of the pupil light reflex. Seven subjects had their pupil light reflex measured before and after consuming 500 ml of alcohol per hour using a pupillometer. The study found statistically significant differences in amplitudes and pre-stimular mydriasis after alcohol intake, with amplitudes being lower and pre-stimular mydriasis being greater. The results were not significant for different color flash stimuli. Differences were also found between values from early intakes compared to later intakes. The results indicate pupil light reflex measurements could potentially distinguish between abstemious and non-abstemious individuals and lead to new alcohol detection devices for road safety.

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    EFFECTS OF ALCOHOL INTAKE ON THE PARAMETERS OF PUPIL

    LIGHT REFLEX.

    Lobato-Rincón LL, Bonnin-Arias C, Navarro-Valls JJ, Ramírez-Mercado JG,


    Cabanillas-Campos MC and Sánchez-Ramos Roda C. (contact mail:
    celiasr@opt.ucm.es).

    School of Optics. University Complutense of Madrid.

    Introduction:
    Static (pupil diameter) and dynamic (latency, constriction velocities and accelerations of
    the light reflex) have been usually studied after the intake of psychoactive substances,
    evaluating the correspondent activity of the nervous system, specifically of the
    autonomous branch.

    Objectives:
    However, the usefulness of the pupillometry quantifying the changes and the variations
    due to the intake of ethanol is not completely understood. The objective of the present
    work was to quantify the evolution of the phases of the pupil light reflex by effect of
    ethanol.

    Material and methods:


    We compared seven subjects before and after an intake of alcohol of 500 ml per hour in
    the same mesopic conditions. Dynamic and binocular pupillometer Power Refractor II
    (Plusoptix, Germany) measured pre-stimular mydriasis, anisocoria in pre-stimular
    mydriasis, latency, amplitude, constriction velocity, constriction acceleration, and
    anisocoria in maximum constriction (choosing the right eye for all cases). We obtained
    the curves and the parameters required processing the records on Java-application
    software software (Cabanillas).

    Results:
    Statistically significant differences (p<0,05) resulted from the comparison pre-post
    between amplitudes (MeanPre: 1,6991±0.5042; MeanPost: 1.5657±0,4928) and pre-
    stimular mydriasis (MeanPre: 6,5279 ± 0,7135; MeanPost: 6,6008393 ± 0,63360482).
    Amplitudes were lower and pre-stimular mydriasis was greater after alcohol intake.
    Moreover, the results were not significant for different colour flash stimuli. However
    we did find differences between the values from the first intakes compared with the last
    intakes.

    Conclusions:
    These results enable us to distinguish between abstemious and non-abstemious
    participants by means of pupil light reflex and may lead to new level-of-alcohol devices
    on road safety.

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