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    VEMP testing was performed on patients with early stage multiple sclerosis (MS) or clinically isolated syndrome (CIS) and compared to healthy volunteers. While 75% of patients had no detectable infratentorial lesions on MRI or clinical exam, VEMP testing found prolonged latencies in their collic and ocular responses compared to healthy volunteers. This suggests VEMP is a sensitive test that can detect subclinical brainstem dysfunction or lesions below MRI detection thresholds in early stage MS and CIS patients.

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    Vestibular evoked myogenic potentials in early stage of MS and clinically isolated syndrome

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    VEMP testing was performed on patients with early stage multiple sclerosis (MS) or clinically isolated syndrome (CIS) and compared to healthy volunteers. While 75% of patients had no detectable infratentorial lesions on MRI or clinical exam, VEMP testing found prolonged latencies in their collic and ocular responses compared to healthy volunteers. This suggests VEMP is a sensitive test that can detect subclinical brainstem dysfunction or lesions below MRI detection thresholds in early stage MS and CIS patients.

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    13 views1 page

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    Uploaded by

    cybergod2200
    VEMP testing was performed on patients with early stage multiple sclerosis (MS) or clinically isolated syndrome (CIS) and compared to healthy volunteers. While 75% of patients had no detectable infratentorial lesions on MRI or clinical exam, VEMP testing found prolonged latencies in their collic and ocular responses compared to healthy volunteers. This suggests VEMP is a sensitive test that can detect subclinical brainstem dysfunction or lesions below MRI detection thresholds in early stage MS and CIS patients.

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    of 1

    Vestibular evoked myogenic potentials in early Crevits L., Venhoovens J.

    ,
    Debruyne J.
    stage of MS and clinically isolated syndrome Departement of neurology, Ghent University Hospital, Belgium

    ABSTRACT Introduction and Purpose RESULTS


    Background and purpose Brainsterm and cerebellar lesions are common in early stages of MS and
    Brainstem and cerebellar lesions are common in clinically isolated syn- CIS. However, many of them might be subclinical. Testing with VEMP is
    drome (CIS) and early multiple sclerosis (MS). Many might be subclinical. thought to be a marker for brainstem function. Therefore, we studied
    Testing w10ith vestibular evoked myogenic potentials (VEMP) is VEMP in patients with early MS and CIS
    thought to be a marker for brainstem dysfonction. The aim of the study
    was to test VEMP in early stages of MS and CIS
    Methods
    Material and methods
    Collic and ocular tap-VEMPs in a group of outpatients with CIS and early Subjects:
    MS where compared to age –matched healthy volunteers .75% of the 20% outpatients with CIS or early MS 75% without any infratentorial sign
    patients did not have any infratentorial lesion on MRI and critical exami- or lesion on clinical examination and MRI 20 age matched healthy
    nation. Peak latencies and standardized amplitudes were measured. volunteers

    Results and conclusions Methods:


    Tap-VEMPs: evoked by forehead taps with a triggered reflex hammer. CONCLUSIONS
    Collic and ocular VEMP latencies of the patients were significantly pro-
    longed compared to healthy volunteers.The standardized p13n23 Registration:over the middle part of the belly off the sternpcleidomas-
    Collic and ocular VEMP latencies of the patients were significantly pro-
    amplitude was significantly enhanced. These findings suggest that toid muscles (collic VEMP) and over the middle part of the lower eyelid ,
    longed. These findings suggest that VEMP is a rather sensitive test, able
    VEMP is a rather sensitive t'est, able to detect subclinical dysfunction or on top of the optical edge (ocular VEMP). During the collic VEMP, subjects
    to detect subclinical dysfunction or lesions beneath detection threshold
    lesions beneath detection threshold of MRI in patients with early MS had to push the chin downward with a constant pressure. During ocular
    of MRI in patients with early MS and clinically isolated syndrome..
    and CIS VEMP, subjects had to deviate the eyes 25 degrees upward.

    Measurements
    Peak latencies and standardized amplitudes

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