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  • Pathophysiology: I N I T I A T I O N

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    Krisna Antolin
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    Initiators like radiation, hormones, and genetics can damage endometrial cells' DNA over prolonged exposure, initiating mutations in genes controlling growth. This impairs inhibitory genes while activating promoting genes, causing uncontrolled proliferation. Promoters like obesity further aggravate the initiated cells, eventually transforming them into malignant neoplasms in a multi-step process of endometrial cancer pathogenesis.

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    Pa Tho Physiology (Cancer)

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    Initiators like radiation, hormones, and genetics can damage endometrial cells' DNA over prolonged exposure, initiating mutations in genes controlling growth. This impairs inhibitory genes while activating promoting genes, causing uncontrolled proliferation. Promoters like obesity further aggravate the initiated cells, eventually transforming them into malignant neoplasms in a multi-step process of endometrial cancer pathogenesis.

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    14 views1 page

    Pathophysiology: I N I T I A T I O N

    Uploaded by

    Krisna Antolin
    Initiators like radiation, hormones, and genetics can damage endometrial cells' DNA over prolonged exposure, initiating mutations in genes controlling growth. This impairs inhibitory genes while activating promoting genes, causing uncontrolled proliferation. Promoters like obesity further aggravate the initiated cells, eventually transforming them into malignant neoplasms in a multi-step process of endometrial cancer pathogenesis.

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    of 1

    PATHOPHYSIOLOGY

    Etiology

    INITIATORS PROMOTERS
    • Chronic exposure to ionizing • Nulliparous
    radiation • Age- post
    • Familial history menopausal (most
    • Race (whites) common)
    • Diet- high intake of
    • Hormonal imbalance (↑levels of animal fat
    extrogen)
    • Obesity
    • Drugs (tamoxifen)
    • Other diseases- HPN,
    • Estrogen replacement therapy
    DM, colon cancer,

    Prolonged exposure of endometrial


    cells to initiators

    Structural damage of
    DNA

    I Mutation of genes that control normal


    growth and replication
    N
    I Failure of DNA repair
    T
    I Defective growth inhibitory regulatory Activation of growth promoting
    A genes regulatory genes
    T
    I
    O
    N Unregulated cellular proliferation
    and differentiation
    Further aggravation caused by
    promoters
    Transformation of normal cells to
    initiated cells

    L
    Further dysfunction of the cellular
    A proliferation and differentiation
    T
    E
    Formation of malignant neoplasm
    N
    C
    Y

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