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Myomas and Cervical Polyps: Pathophysiology Insights

Estrogen and progesterone receptors are more concentrated in myomas than the normal surrounding tissue. The growth rate of myomas is related to their concentration of estrogen and progesterone receptors. Treatment with gonadotropin-releasing hormone agonists temporarily reduces the size of myomas by 45% after 24 weeks, though they return to their original size once treatment is stopped.

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Erjohn Vincent Lim
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151 views1 page

Myomas and Cervical Polyps: Pathophysiology Insights

Estrogen and progesterone receptors are more concentrated in myomas than the normal surrounding tissue. The growth rate of myomas is related to their concentration of estrogen and progesterone receptors. Treatment with gonadotropin-releasing hormone agonists temporarily reduces the size of myomas by 45% after 24 weeks, though they return to their original size once treatment is stopped.

Uploaded by

Erjohn Vincent Lim
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd

"Estrogen and progesterone receptors are in higher concentrations in myomas than inthe

normal surrounding myometrium. The growth rate of myomas is related to their number of estrogen and
progesterone receptors. Gonoadotrophic-releasing hormone agonists result in a temporary reduction in
the size of myomas by 45% at 24 weeks of treatment. "

"Pathophysiology- Leiomyoma (myoma) -


The majority of women with uterine leiomyomas are asymptomatic; they become symptomatic in
approximately 25% of cases5. Symptomatic leiomyomas are among the most common reasons
for hysterectomy in the United States6.
Leiomyomas are spherical or ovoid in shape and have a whirled appearance on cut surface. Large
leiomyomas may outgrow their limited blood supply; resulting in hyaline or cystic degeneration. As the
blood supply to a leiomyoma decreases, it may become calcified.
Estrogen and progesterone receptors are in higher concentrations in leiomyomas than in the normal
surrounding myometrium7. The growth rate of leiomyomas is related to their number of estrogen and
progesterone receptors8. Gonoadotrophic-releasing hormone agonists result in a temporary reduction in
the size of leiomyomas by 45% at 24 weeks of treatment. However, once the medication is discontinued,
the leiomyomas return to their former size in 6 months9.
Pathophysiology - cervical polyp-
Hyperplastic growth of the glands and stroma.
Endometrial glands covered by pseudo-stratified epitelium, juxtaposed and with cystic areas, inserted in
fibro-vascular stroma.
The polyps hold a varied number of glands, stromas and blood vessels.
In the majority of cases the hystologic situation is the simple hyperplasia of the uterine mucous
membrane; at times, almost every gland is dilated (cystic hyperplasia).
Most of them present an immature basal endometrium histological pattern, which in general does not
respond to hormonal stimulus. "
Source(s):
Found those on various websites.

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