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  • KamanJan Primaquine

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    Primaquine acts by interfering with the mitochondria of parasites, cutting off their energy supply and killing them to stop infections and allow recovery. Common side effects include nausea, vomiting, abdominal cramps, and leukopenia. It can cause hemolytic anemia in G6PD deficient individuals and is contraindicated in children under 1 year old, those with acute systemic diseases, pregnancy, and lactation. The recommended dosage for vivax or ovale malaria is 15 mg daily for 14 days, and for prevention of chloroquine-resistant malaria is 30 mg daily started 1-2 days before travel and continued for 7 days after departure from an endemic area.

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    Primaquine acts by interfering with the mitochondria of parasites, cutting off their energy supply and killing them to stop infections and allow recovery. Common side effects include nausea, vomiting, abdominal cramps, and leukopenia. It can cause hemolytic anemia in G6PD deficient individuals and is contraindicated in children under 1 year old, those with acute systemic diseases, pregnancy, and lactation. The recommended dosage for vivax or ovale malaria is 15 mg daily for 14 days, and for prevention of chloroquine-resistant malaria is 30 mg daily started 1-2 days before travel and continued for 7 days after departure from an endemic area.

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    10 views1 page

    KamanJan Primaquine

    Uploaded by

    kimberly_caberte
    Primaquine acts by interfering with the mitochondria of parasites, cutting off their energy supply and killing them to stop infections and allow recovery. Common side effects include nausea, vomiting, abdominal cramps, and leukopenia. It can cause hemolytic anemia in G6PD deficient individuals and is contraindicated in children under 1 year old, those with acute systemic diseases, pregnancy, and lactation. The recommended dosage for vivax or ovale malaria is 15 mg daily for 14 days, and for prevention of chloroquine-resistant malaria is 30 mg daily started 1-2 days before travel and continued for 7 days after departure from an endemic area.

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    CAPITOL UNIVERSITY

    COLLEGE OF NURSING DRUG CONTRAINDICATIONS ADVERSE EFFECTS OF THE DRUGS Primaquine acts by interferingHypersensitivity. Children Nausea, with a part of the parasite<1 yr. Acute flare-ups of vomiting, (mitochondria) that is responsiblesystemic diseases (RA, epigastric distress, for supplying it with energy.SLE) having tendency for abdominal cramps, Without energy the parasite dies.agranulocytopaenia, leukopaenia, l This stops the infection fromPregnancy and lactation. eucocytosis, continuing and allows the person agranulocytosis, to recover. methaemoglobinemia in NADH . methaemoglobin reductase-deficient individuals. Potentially Fatal: Haemolytic anaemia (G6PD deficient), thrombocytopaenia, leucopaenia, AV block. DRUG STUDY MECHANISM OF ACTION

    PRIMAQUINE
    DOSAGE: Adult: PO Radical treatment of vivax or ovale malaria 15 mg/day for 14 days. Higher doses or longer courses may be required if resistance in P.vivax occurs. Prevention of chloroquineresistant malaria 30 mg once daily; to be started 1-2 days before travel and continue for 7 days after departure from the malaria endemic area. ADMINISTRATION: Should be taken with food. (Take w/ meals to avoid GI discomfort.)

    Issue: 05 April 2006 Code:003

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