Mindanao State University – Iligan Institute of Technology Student: SALIMBAGAT, CHRISTINE.

P Section: 262
COLLEGE OF NURSING

PHARMACOLOGY

DRUG STUDY

Brand Name: Zyvox Generic Name: Linezolid Drug Classification: Oxazolidinones

Dosage, Route & Frequency Drug-Drug & Drug- Side Effects Adverse Reactions
Drug Action Indications Contraindications
Recommended Prescribed Food Interactions (By System) (By System)
Vancomycin-Resistant Enterococc Inhibits Drug: MAO Treatment of -Hypersensitivity to linezolid, pregnancy CNS: Headache, Body as a
us faecium bacterial INHIBITORS may cause vancomycin- (category C), lactation, neonates. Safety dizziness Whole: Fever.
Adult/Adolescent: PO/IV >12 protein hypertensive resistant and effectiveness in children <2 y not GI: Mild GI: Diarrhea,
y, 600 mg q12h x 14–28 d synthesis at crisis; pseudoephedrin (VREF) Enterococc established. diarrhea or nausea, vomiting,
Child: PO/IV 2–11 y, 10 mg/kg q8 the level of e may cause elevated us -Cautious Use: Lactation, history of vomiting, constipation, taste
h x 14–28 d the 23S BP; may faecium, nosocom thrombocytopenia, thrombocytopenia; constipation, alteration, abnormal
Nosocomial or Community- ribosome of cause serotonin syndro ial pneumonia, patients on MAOI, or serotonin reuptake nausea or LFTs, tongue
Acquired Pneumonia, Complicated the 50S me complicated and inhibitors, or adrenergic agents, active stomach pain. discoloration.
Skin Infections subunit. with citalopram, escital uncomplicated alcoholism, anemia, bleeding, bone white patches Hematologic: Throm
Adult/Adolescent: PO/IV >12 Therapeutic opram. skin and skin marrow suppression, cardiac in the mouth, bocytopenia,
y, 600 mg q12h x 10–14 d Effects: Food: TYRAMINE structure arrhythmias, cardiac disease, color changes leukopenia.
Child: PO/IV 5–11 y, 10 mg/kg Bactericidal CONTAINING infections, cerebrovascular disease, chemotherapy, of tongue CNS: Headache,
q8h x 10–14 d action against FOOD may cause community- coagulopathy, colitis, diarrhea, Skin: Mild skin insomnia, dizziness.
Uncomplicated Skin Infections streptococci; elevated acquired hypertension, hyperthyroidism, rash Skin: Rash. Urogenit
Adult/Adolescent: PO >12 y, 600 bacteriostatic BP. Herbal: Ginseng, ep pneumonia due to leukopenia, MI, PKU disorder, Reproductive: al: Vaginal
mg q12h x 10–14 d action against hedra, ma huang may susceptible gram- radiographic contrast administration, Vaginal moniliasis.
Child: PO <5 y, 10 mg/kg q8h x 10– enterococci lead to elevated BP, positive spinal anesthesia, surgery, hypertension; itching or
14 d 5–11 y, 10 mg/kg q12h x 10– and headache, organisms. phenylketonuria; carcinoid syndrome. discharge
14 d staphylococci. nervousness.
Responsibilities in the Nursing Process (ADPIE) Responsibilities in the Nursing Process (ADPIE)
A - Assess for infection(vital signs; appearance of wound, sputum, urine, and stool; WBC), Follow the SEVEN RIGHTS of medication preparation.
obtain specimens for culture and sensitivity. Obtain specimens for culture and sensitivity. Complete necessary focused assessments, lab values, and/or vital signs, and document on MAR.
Monitor visual function in patients receiving linezolid for 3 mo or who report visual Provide patient education as necessar0y.
symptoms. Monitor bowel function. Monitor patient taking serotonergic drugs for signs of I – Dose adjustment is not necessary when switching from IV to oral dose. PO: May be administered
serotonin syndrome with or without food. Before using oral solution gently invert 3–5 times to mix; do not shake. Store at
D - Risk for infection (Indications), Diarrhea (Adverse Reactions) room temperature.
P - Plan medication administration to avoid disruption. E - Resolution of signs and symptoms of infection. Length of time for complete resolution depends on
Prepare medications for ONE patient at a time. Check expiration date. organism and site of infection