Name of Drug Generic Name: Omeprazol e Brand Name: Prilosec, Zegerid Patients Dose: 20mg tab P.O.

OD Minimum Dose: 20 mg Maximum Dose: 20 mg

Classificatio n General classification: Proton pump inhibitor Functional classification: Antisecretory drug

Mechanis m of Action Gastric acid-pump inhibitor: Suppresses gastric acid secretion by specific inhibition of the hydrogenpotassium ATPase enzyme system at the secretory surface of the gastric parietal cells; blocks the final step of acid production

Indications >Short-term treatment of active duodenal ulcer >First-line therapy in tx of heartburn or symptoms of GERD >Short-term tx of active benign gastric ulcer >GERD, severe erosive esophagitis, poorly responsive symptomatic GERD >Long term therapy: treatment of pathologic hypersecreto ry conditions >Eradication of helicobacter pylori with amoxicillin or

Contraindicatio ns Contraindicated with hypersensitivity to omeprazole or its components Use cautiously with pregnancy, lactation

Adverse reactions >CNS: headache, dizziness, asthenia, vertigo, insomnia, apathy, anxiety, paresthesia, dream abnormalities >Dermatolog ic: Rash, inflammation , urticaria, pruritus, alopecia, dry skin >GI: diarrhea, abdominal pain, nausea, vomiting, constipation, dry mouth, tongue atrophy >Respiratory : URI symptoms, cough, epistaxis

Nursing Responsibiliti es Before: Administer before mealsCaution patient to swallow whole Do not use any other liquid or food to dissolve During: Provide safety because it can cause dizziness After: Report severe headache, worsening of symptoms, fever, chills

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