IMMUNITY TO BACTERIAL, VIRAL AND FUNGAL INFECTIONS

MCQs

1- Which of the following statements regarding TLRs is correct?

a)

b) c)

d)

They are a part of acquired immunity to extracellular bacteria. They have no role in immunity to fungi. They are a part of innate immunity to bacteria. They are present on different organisms including bacteria, viruses and fungi.

2- Which of the following statements is incorrect, in relation to NK cells?

a)

b)
c)

d)

They can destroy virus-infected cells. They secrete IFN-. They play a role in acquired immunity to bacteria. They play a role against intracellular bacteria.

3- Which of the following is not a part of the innate immunity to bacteria?

a)

b)
c) d)

NK cells. Phagocytosis. Commensal bacteria. Neutralization of bacterial toxins.

4-Choose the incorrect statement in relation to humoral immunity to microorganisms:

a)

b)

c)

d)

Antibodies can act as opsonins and enhance phagocytosis of bacteria. Antibodies can activate complement by binding to their specific antigens. Antibodies are secreted by activated Thelper cells. Antibodies can prevent viral attachment to receptors on susceptible cells.

5-Choose the incorrect statement concerning interferons.

INF- is produced by virus infected cells. b) IFN- activates phagocytes to kill intracellular microbes. c) IFNs act late in viral disease following the appearance of antibodies. d) INF- activates NK cells to kill virus infected cells.
a)

True or False?
a)

b)

c)

d)

e)

Disseminated fungal infections are seen in immunodeficient persons. Activated macrophages can kill virus infected cells. IgA on mucosal surfaces helps bacterial adherence to their target cells. Agglutination of bacteria protects them from phagocytosis. Activated T helper cells release cytokines which enhance the microbicidal functions of phagocytes.

True or False?
f) Neutrophils and macrophages play an important role in elimination of fungi. g) Humoral immunity is more effective against intracellular bacteria, while cellular immunity is more important against extracellular bacteria. h) Intracellular bacteria are generally resistant to phagocytosis. i) Infected cells are destroyed by T-helper cells. J) ADCC refers to lysis of virus infected cells binding antibody, by NK cells .

Model answer:
MCQ 1-c 2-c 3-d 4-c

5-c
T or F a)-T b)- T c)- F d)- F e)- T f)- T g)- F h)- T i)- F J)- T