CHEMISTRY FOR LIFE SCIENCES

Workshop covering: hydrogen bonding

1. Draw and label a typical hydrogen bond. Ensure that you include all participating atoms.

2. For each oI the Iollowing molecules, decide whether they will exhibit hydrogen bonding
when studied as pure substances. II they do, draw a pair oI molecules showing the hydrogen
bonds.

H
5
C
2
O
C
2
H
5
OH
C H
3
C H
3
C H
3
C H
3
OH
O
H
5
C
2
C
2
H
5
O
N H


3. The core oI DNA is composed oI nitrogen rich cyclic structures ('bases) held together by
hydrogen bonds. The pairs oI structures show the most common bases lined up as they are in DNA.
For each pair identiIy how many plausible hydrogen bonds can be Iormed and show the donor and
acceptor Ior each. Which pair is held together most strongly?

N
O
N
O Me
H
DNA
N
N
N
N
N
H
H
DNA
N
DNA O
N
N H
H
N
N
N
N
N
O
H
H
H
DNA

N
O
N
O Me
H
DNA
N
N
N
N
N
H
H
DNA
N
DNA O
N
N H
H
N
N
N
N
N
O
H
H
H
DNA