List of Available Bioanalytical Methods

Name

Species

Matrix

Equipment

RANGE or LOQ

2-phenylethanol 6-Mercaptopurine 7-Ethyl-10-Hydroxy camptothecin (Met of Irinotecan) 10-Hydroxy Oxcarbamazepine Acetylsalicylic acid Acyclovir Acyclovir Acyclovir Alfentanyl Alprazolam + metabolites Alprazolam + metabolites Amino-2-chloro-5-Benzophenone Amlodipine Amoxicillin Amoxicillin Amoxicillin Ampicillin Apomorphin Apomorphin Atazanavir Atracurium Bacitracin Benzoate phenethyl benzoate Benzoic acid Benzoylecgonine Bromoxynil Cadaverine Caffein Caffein Caffein Candoxatril Candoxatril Candoxatrilat Carbamazepine Carbamazepine epoxide Carbofuran Carboplatin Carboplatin unbound Carbosulfan Carbosulfan + metabolite: carbofuran Carbosulfan + metabolite: carbofuran Cefadroxil Cephapirin and Desacetylcephapirin Cephapirin and Desacetylcephapirin Cephapirin and Desacetylcephapirin Cephapirin and Desacetylcephapirin Chlorhexine Human Bovine Bovine Bovine Bovine Human Human Human Human Human Bovine Human Human Human Human Human Human Human Human Human Pig Human Human Pig Human Dog Human Human Bovine Dog Human Human Human Human Human Human Dog Human Human

Methanol Plasma Plasma H and EDTA Plasma Plasma H Serum Plasma Urine Plasma Plasma H-Li Urine Plasma H-Li Plasma EDTA 3k Serum Urine Plasma EDTA 3k Plasma EDTA Plasma EDTA Plasma H-Na Plasma Milk Methanol Methanol Urine Blood Plasma Plasma H-Li Plasma Plasma Plasma Urine Urine Plasma Plasma Formulation Plasma Plasma Formulation Meat, milk and eggs

HPLC-UV (260 nm) LC-MS/MS HPLC- Fluo HPLC HPLC-UV (228 nm) HPLC LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC-UV (254 nm) LC-MS/MS LC-MS/MS HPLC HPLC LC-MS/MS LC-MS LC-MS LC-MS/MS HPLC LC-MS/MS HPLC-UV (260 nm) HPLC-UV (260 nm) GC-MS GC-MS LC-MS/MS HPLC-UV (275 nm) LC-MS/MS HPLC HPLC HPLC HPLC HPLC HPLC GC/FID LC-MS/MS LC-MS/MS HPLC-UV (280 nm) LC- pickering- Fluo GC-MS

10 - 50 g/ml 2 - 500 ng/ml 0,5 - 100 ng/ml 6 g/ml 0,25 - 15 g/ml 10 ng/ml 10 ng/ml 100 ng/ml 0,05 ng/ml 0,1 - 50 ng/ml 1 - 100 ng/ml 0,2 - 10 ng/ml 50 - 5000ng/ml 50 ng/ml 50 ng/ml 50 - 5000ng/ml 0,2 - 30 ng/ml 1 - 200 ng/ml 50 - 25000 ng/ml 20 ng/ml 75 ng/ml 0,7 - 100 g/ml 0,2 - 50 g/ml 5 g/ml 10 ng/ml 25 - 2015,5 ng/ml 200 ng/ml 1 mg/l 50 ng/ml 50 ng/ml 50 ng/ml 0,5 g/ml 0,4 g/ml 50 ng/ml 50 ng/ml 5 - 50 g/ml 25 - 250 ng/ml 1 - 20 ng/ml met: 5 - 100 ng/ml 0,2 - 50 g/ml 2,5 ng/ml 7,5 ng/gr 12,5 ng/gr 7,5 ng/gr 1 - 50 ng/ml

Plasma Milk Fat Kidney Muscle Plasma H-Li

HPLC-UV (226 nm) LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS

Ciprofloxacin

Rabbit

Plasma Aqueous humor, palpebral conjunctiva, bulbar conjunctiva, cornea, sclera Plasma H Serum Plasma H-Li Urine Plasma Plasma Plasman H-Li Plasma H-Li Plasma H-Li Urine Urine Liver Fat Kidney Muscle Liver Fat Kidney Muscle Blood Formulation Alopexy Plasma Urine Plasma H-Li Plasma Urine Plasma Urine Plasma Plasma H-Li Plasma Urine Plasma H-Na Urine Plasma H-Li Plasma H-Li acid Urine Blood

LC-MS/MS

2 - 100 ng/ml 40 - 1000 ng/g sclera: 40 - 10000 ng/g 2 - 100 ng/ml 50 ng/ml 0,1 - 50 ng/ml met: 0,2 - 100 ng/ml 0,1 - 50 ng/ml met: 0,2 - 100 ng/ml 0,05 ng/ml 0,1 ng/ml 20 - 2000 ng/ml 5 - 2000 ng/ml 20 - 2000 ng/ml 5 g/ml 5 g/ml 0,25 ng/gr 0,25 ng/gr 0,25 ng/gr 0,25 ng/gr 0,25 ng/gr 0,25 ng/gr 0,25 ng/gr 0,25 ng/gr 5 ng/ml 25 ng/ml 3 ng/ml Dextro: 2 - 200 ng/ml Nor: 5 - 200 ng/ml 25 ng/ml 3 ng/ml 100 ng/ml 100 ng/ml 100 ng/ml 200 - 5000 ng/ml 100 ng/ml 100 ng/ml 0,1 - 5 ng/ml 1 - 100 ng/ml 5 - 500 ng/ml 0,95 - 95 ng/ml 0,95 - 95 ng/ml 10 ng/ml 4,0 - 200 ng/ml 50 - 5000 ng/ml 0,5 - 400 ng/ml 0,5 - 400 ng/ml 30 - 3000 ng/ml 10 - 10000 ng/ml 100 ng/ml 100 ng/ml 5 ng/ml 20 g/ml 200 - 5000 ng/ml 5 - 100 g/ml 0,5 ng/ml 0,1 ng/ml

Ciprofloxacin

Rabbit

LC-MS/MS

Cisapride Clavulanic acid Clonazepam + metabolite: 7-aminoclonazepam Clonazepam + metabolite: 7-aminoclonazepam Cloprostenol Cloprostenol Cloricromenic acid Cloricromenic acid Cloricromen and cloricromen acid Cocain Codeine Cronolone Cronolone Cronolone Cronolone Cronolone Cronolone Cronolone Cronolone Cyclosporin A Desoxyminoxidil Dextromethorphan Dextromethorphan Dextropropoxyphene + Norpropoxyphene Dextrorphan Dextrorphan Diclofenac Diclofenac Dideoxyinosine Diethylene glycol monoethyl ether (DEGMEE) Diflunisal Diflunisal Digoxin Digoxin Diltiazem Diphencyprone (DCP) Diphencyprone (DCP) DNOC Doxorubicin Doxorubicin Doxycycline Enalapril Enalaprilat Erythromycin Esomeprazole Ethacrynic acid Ethacrynic acid Ethinylestradiol Ethosuximide Ethoxy ethoxy acetic acid (EEAA) Ethoxy ethoxy acetic acid (EEAA) Everolimus Everolimus

Human Human Human Human Bovine Pig Beagle dog Rat Sd/ Mouse CD Beagle dog Human Human Sheep Sheep Sheep Sheep Goat Goat Goat Goat Human Human Human Human Human Human Human Human Human Rat SD Human Human Human Human Human Human Human Human

HPLC-UV HPLC LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS GC-MS GC-MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC-UV (240 nm) LC-MS/MS LC-MS/MS HPLC-UV (238 nm) LC-MS/MS LC-MS/MS HPLC HPLC HPLC LC-MS/MS HPLC HPLC LC-MS/MS LC-MS/MS HPLC-UV (238 nm) LC-MS/MS LC-MS/MS HPLC HPLC-Fluo LC-MS/MS

Human Human Human Human Human Human Human Human Human Rat SD Rat SD Human Human

Plasma H-Li Plasma H-Na Plasma H-Na Plasma H-Na Plasma EDTA Plasma Urine Plasma Plasma Plasma H-Li Urine Blood Blood

LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC HPLC GC-MS HPLC LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS

Faslodex (Fulvestrant) Faslodex (Fulvestrant) Felodipine Fenofibric Acid Flunixin Flunixin Flurbiprofen R-, S-, Flurbiprofen Furosemide Furosemide Gabapentin Ganciclovir Ganciclovir Gefinitib Gefinitib Gefinitib + o-desmethyl metab Glibenclamide Gliclazide Gliclazide HCA Hyperzin A Hyperzin A Hypericin Ibuprofen Ibuprofen R-, S- Ibuprofen R-, S- Ibuprofen Imipramin Indapamide Indomethacin Indomethacin Ioxilan Ioxilan Irinotecan Itraconazole + metabolite Ketoconazole Ketoprofen Ketoprofen Lamotrigine Laudanosine Levetiracetam (Keppra) Levidopa (L-DOPA) Levidopa (L-DOPA) Levonorgestrel Lidocaine Lidocain and mono n-dealkylated met Loratadine Magnolol/Honokiol Magnolol/Honokiol Magnolol/Honokiol Meclofenamic acid Meclofenamic acid Mefenamic acid Mefenamic acid Metformin Metformin Methotrexate Methotrexate + 7-OH metabolite Metoclopramide Midazolam

Human Rat Human Human Human Human Human Human Human Human Human Human Human Human Human Human Rabbit Human Rabbit Rat Rat SD Dog beagle Human Human Human Human Human Human Human Human Human Human Human Human Human Human Human Human Human Human Human Monkey Rat Human Human Human

Plasma Plasma Plasma Plasma Plasma Urine Blood, Plasma, Urine Serum and Synovial Fluid Plasma Urine Blood Plasma Urine Plasma Jejunal fluid Plasma Plasma Plasma Plasma Plasma Plasma H-Na Plasma H-Na Plasma Serum Urine Phasma H and Serum Urine Plasma Plasma H-Li Plasma Urine Plasma H-Na Urine Plasma H and EDTA Plasma EDTA Plasma Plasma Urine Plasma Plasma Plasma Plasma K3EDTA Plasma K3EDTA Plasma Plasma Plasma 1% CMC Propylene Glycol 1% CMC

LC-MS/MS LC-MS/MS LC-MS/MS HPLC-UV (287 nm) HPLC HPLC LC-MS/MS HPLC- Fluo HPLC HPLC LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC- UV (229 nm) HPLC- UV (229 nm) HPLC- UV (229 nm) HPLC- UV LC-MS/MS LC-MS/MS HPLC- Fluo HPLC HPLC HPLC- UV HPLC- UV HPLC- UV (210 nm) LC-MS/MS HPLC HPLC HPLC- UV (245 nm) HPLC- UV (245 nm) HPLC- Fluo LC-MS/MS HPLC- Fluo HPLC HPLC HPLC HPLC LC-MS/MS LC-MS/MS LC-MS/MS GC-MS GC-MS GC-MS LC-MS/MS HPLC-UV HPLC-UV HPLC-UV HPLC HPLC HPLC HPLC LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC- Fluo LC-MS/MS

0,25 ng/ml 1 ng/ml 0,5 ng/ml 0,2 - 20 g/ml 100 ng/ml 100 ng/ml 50 - 6000 ng/ml 0,100 - 50 g/ml 100 ng/ml 100 ng/ml 1,5 g/ml 10 ng/ml 100 ng/ml 0,5 ng/ml 0,5 g/ml 1 ng/ml

1 - 25 ng/ml 1 - 25 ng/ml 5 - 40 ng/ml 5 g/ml 5 g/ml 0,5 - 50 g/ml 1,25 - 125 g/ml 1 - 10 ng/ml 100 ng/ml 100 ng/ml 0,2 - 10 mg/ml 1,0 - 30 mg/ml 2 - 100 ng/ml 2 - 250 ng/ml 0,1 - 8 g/ml 100 ng/ml 100 ng/ml 0,5 g/ml 20 ng/ml 3 g/ml 0,02 - 30 g/ml 0,02 - 30 g/ml 10 ng/ml 0,1 ng/ml 0,1 - 20 ng/ml 5 - 25 g/ml 1 - 25 g/ml 5 - 25 g/ml 100 ng/ml 100 ng/ml 100 ng/ml 100 ng/ml 5 g/ml 2 ng/ml 1 ng/ml 2,5 - 200 ng/ml 0,2 ng/ml

Human Human Human Human Human Human Mouse Human Human Human

Plasma Urine Plasma Urine Urine Plasma Plasma Plasma Plasma Plasma

Midazolam + metabolite Mogroside V Morphine MPA MPA, MPAG, acyl MPAG MPA, MPAG, acyl MPAG MPA, MPAG, acyl MPAG MPA, MPAG, acyl MPAG Mycophenolic acid and glucoronide conjugate Mycophenolic acid and glucoronide conjugate Mycophenolic acid and glucoronide conjugate Naproxen Naproxen Nefopam Netilmicin

Human Roden Human Mouse Human Dog Human Dog Human Human Dog Human Human Human Rabbit

Plasma H-Li Feed Urine Serum Blood Plasma Urine Urine Plasma Urine Urine Plasma Urine Plasma Plasma Aqueous humor, palpebral conjunctiva, bulbar conjunctiva, cornea, sclera Plasma Plasma H-Li Plasma Plasma Liver Fat Kidney Muscle Plasma Plasma Urine Organs Plasma H-Li Plasma Plasma Plasma Urine Plasma Plasma H-Li Plasma H-Li Plasma H-Li Blood Plasma Plasma Urine Plasma Plasma Plasma Plasma H Formulation Blood Blood Urine Plasma H-Na Plasma H-Na Plasma H-Na Plasma Plasma Urine Plasma

LC-MS/MS HPLC-UV GC-MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC HPLC HPLC HPLC HPLC HPLC-UV (210 nm) LC-MS/MS

0,1 - 10 ng/ml 10 - 250 g/ml 5 g/ml 6 - 3330 ng/ml 40 ng/ml 40 ng/ml 100 ng/ml 100 ng/ml 100 ng/ml 1 g/ml 1 g/ml 100 ng/ml 100 ng/ml 5 - 500 ng/ml 5 - 200 ng/ml AH: 40 - 1000 ng/g sclera: 300 - 10000 ng/g other: 40 - 10000 ng/g 0,4 - 30 ng/ml 0,1 - 10 ng/ml 0,5 ng/ml 5 ng/ml 0,1 ng/gr 0,1 ng/gr 0,1 ng/gr 0,1 ng/gr 0,5 ng/ml 100 ng/ml 100 ng/ml 50 - 15000 ng/ml 100 - 10000 ng/ml 1,5 g/ml 100 ng/ml 100 ng/ml 0,5 g/ml 1,0 - 50,0 ng/ml 0,5 - 20 ng/ml 1 - 100 ng/ml 0,5 g/ml 2,5 g/ml 100 ng/ml 100 ng/ml 10 - 500 ng/ml 20 - 800 ng/ml 10 ng/ml 6,40 - 800 ng/ml 0,1 ng/ml 0,1 ng/ml 20 - 2000 ng/ml 250 - 6000 ng/ml 5 - 20000 ng/ml 0,10 - 50 g/ml 2 ng/ml 1 nmol/l 10 nmol/l 100 ng/ml

Netilmicin

Rabbit

LC-MS/MS

Nicardipin Nicotin + metabolite: cotinin Nifedipine Nolvadex Norgestomet Norgestomet Norgestomet Norgestomet Omeprazole Oxyphenylbutazone Oxyphenylbutazone Palladium Paracetamol Paracetamol Phenobarbital Phenylbutazone Phenylbutazone Phenytoin Pinaverium Bromide Prednisone Prednisolone, hydrocortisone Pregabalin Primidone Probenecid Probenecid Pseudoephedrin Ranitidine Ranitidine Ranitidine Regulin-Melovine Remifentanil Remifentanil + metabolite Remifentanil + metabolite Rhein Rhein Rhein Rifampicin Risperidone + 9-hydroxyrisperidone Salbutamol Salbutamol Salicylic acid

Human Human Human Human Bovine Bovine Bovine Bovine Human Human Human Human Rat, monkey Human Human Human Human Human Human Human Human Human Human Human Human Human Human Human Sheep Human Human Human Human Dog beagle Human Human Human Human Human

GC-MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC HPLC LC-MS/MS HPLC-UV (254 nm) HPLC-UV (254 nm) HPLC HPLC HPLC HPLC LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC HPLC HPLC HPLC-UV (205 nm) HPLC-UV (228 nm) HPLC HPLC-UV HPLC-UV (223 nm) LC-MS/MS LC-MS/MS LC-MS/MS HPLC- Fluo HPLC- UV (431 nm) and HPLC- Fluo HPLC- Fluo HPLC GC-MS GC-MS HPLC

Plasma H-Na acid ascorbic LC-MS/MS

Salicylic acid Simvastatin Sirolimus Sodium Bicarbonate Spyramycine Sufentanil Sulindac Sulindac Tacrolimus Tazarotene Tazarotenic acid TCN, TCN-P Terbutaline Testosterone Theophylline Thiocolchicoside Thyroxine (LT4) and Triiodo-thyroxine (LT3) Tiagabine Tianeptin Tiapride Tiapride Tiaprofenic acid Tobramycin

Human Human Human Human Dog Human Human Human Human Human Human Human Human Human Human Human Human Human Dog, rat Dog, rat Human Rabbit

Urine Plasma H Blood Formulation Plasma Plasma Plasma Urine Blood Plasma H-Na Plasma H-Na Plasma Plasma Plasma Serum Plasma Plasma H-Li Blood Plasma H-Li Plasma, brain, liver Plasma Plasma Plasma aqueous humor, palpebral conjunctiva, bulbar conjunctiva, cornea, sclera Plasma Blood Plasma Feces Feces Plasma K3EDTA Plasma Urine Blood Plasma H Urine Plasma Plasma H-Li Plasma Urine Plasma H-Li Urine Feed Plasma H-Na Plasma H Blood

HPLC LC-MS LC-MS/MS Titrimetry LC-MS LC-MS/MS HPLC HPLC LC-MS/MS GC-MS GC-MS LC-MS/MS GC-MS LC/MS HPLC LC/MS LC-MS/MS LC-MS/MS HPLC-UV (220 nm) HPLC- Fluo HPLC- Fluo HPLC-UV (305 nm) LC-MS/MS

100 ng/ml 4 - 500 ng/ml 0,5 ng/ml 0,025 - 3 g/ml 0,05 ng/ml 100 ng/ml 100 ng/ml 0,2 ng/ml 0,02 - 0,5 ng/ml 0,5 - 10,0 ng/ml 1 nmol/l 0,5 - 30 ng/ml 1 mg/l 0,5 - 25 ng/ml LT4: 10 - 200 ng/ml LT3: 0,5 - 10 ng/ml LT4-C6: 10 - 200 ng/ml 10 ng/ml 10 - 400 ng/ml 3 - 2000 ng/ml 50 - 10000 ng/ml 10 - 40 g/ml 5 - 200 ng/ml

Tobramycin

Rabbit

LC-MS/MS

40 - 1000 ng/g

Tolterodine Topiramate Triptolide Tylosine A Tylosine D Tyramine Valganciclovir Valganciclovir Valproic acid Valproic acid Valproic acid Veralipride Verapamil + Norverapamil Vesicare Vesicare Vinflunine Vistarem Vitamin C Warfarin enantiomers R/S Warfarin enantiomers R/S Zonisamide

Human Human Human Pig Pig Human Human Human Human Human Human Human Human Human Human Human Human Rodent Human Human Human

GC-MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS GC GC GC-MS LC-MS/MS LC-MS/MS LC-MS/MS LC-MS/MS HPLC-UV (290 nm) HPLC-UV LC-MS/MS HPLC- Fluo LC-MS/MS

0,3 ng/ml 1,3 g/ml 0,3 g/g 1,5 g/g 0,5 - 500 ng/ml 10 ng/ml 100 ng/ml 10 g/ml 10 - 250 g/ml 40 - 1000 g/ml 10 - 800 ng/ml 10- 500 ng/ml 0,5 ng/ml 0,5 ng/ml 0,25 - 200 ng/ml 34,8 - 696 mol/L 25 - 1750 ng/ml 7,50 - 2500 ng/ml 5 g/ml