Sensory Input & Responses

Case 2 A true case of

depr|vat|on
O !,r,thyroid
gl,nds -
"triggered by
decre,se in blood
c,lcium, rele,se
p,r,thormone
O Receptors on
osteocl,sts bind
p,r,thormone
O steocl,sts
stimul,ted to
dissolve bone,
rele,sing c,lcium
O Result blood
c,lcium rises .,nd
rises .,nd rises
.until its too much
@e Antagon|st
O ells in thyroid
gl,nd triggered to
rele,se c,lcitonin
O Receptors on
osteobl,sts bind
c,lcitonin, build
new bone
O Result c,lcium
level in blood f,lls
O oth sets of ,ctions
Homeost,sis
O Simil,r ,nt,gonistic re,ctions
occur with.
4 Insulin ,nd gluc,gon
4 Insulin promotes cellul,r
upt,e of glucose
4 luc,gon promotes bre,down of liver stores of glycogen to
glucose
Case 3 Vascu|ar Lndote||a| Growt Iactor
O lood vessel growth during development, following injury
nterest 1
O ene constitutively expressed in m,ny tumors well supplied
4 Rese,rch - bloc loc,l VE effect, tumor dies
nterest 2
O Rese,rch coron,ry ,rtery byp,ss - grow new blood vessels
,round bloced ,rtery by ,pplying VE
Ce|| S|gna| Cascades
O ipid soluble hormone enters cell, binds to receptor in cytosol
O omplex moves to nucleus, binds ,nd ,ctiv,tes (or de,ctiv,tes) ,
"gene

O ,ter soluble hormone binds to "tr,ns-membr,ne receptor
O Inside cell, ,ctiv,ted receptor "t,il ,ctiv,tes ,nother protein or
enzyme
O %his m,y ,ctiv,te , third, usu,lly ,n enzyme multiple products
quicly (second,ry messengers)
O %hese ,ctiv,te other enzymes or m,ssive rele,se of ions or ,ffect
gene tr,nscription
O The hormonal "signal" is "amplified" within the cell at
almost every step
O ne molecule c,n potenti,lly h,ve m,ssive cellul,r effect