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    Ragvi Balu
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    The document discusses changes to the glomerular basement membrane that result in a loss of negative charge. Specifically, it notes a reduction in heparan sulfate and total glycosaminoglycans content, which affects the membrane's architecture and ability to act as a selective barrier. This loss of negative charge allows for accumulation and cross-linking of proteins in the membrane, stimulating macrophage synthesis of monokines and increased protein production, cell proliferation, and vascular permeability.

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    The document discusses changes to the glomerular basement membrane that result in a loss of negative charge. Specifically, it notes a reduction in heparan sulfate and total glycosaminoglycans content, which affects the membrane's architecture and ability to act as a selective barrier. This loss of negative charge allows for accumulation and cross-linking of proteins in the membrane, stimulating macrophage synthesis of monokines and increased protein production, cell proliferation, and vascular permeability.

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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    13 views1 page

    Presentation 1

    Uploaded by

    Ragvi Balu
    The document discusses changes to the glomerular basement membrane that result in a loss of negative charge. Specifically, it notes a reduction in heparan sulfate and total glycosaminoglycans content, which affects the membrane's architecture and ability to act as a selective barrier. This loss of negative charge allows for accumulation and cross-linking of proteins in the membrane, stimulating macrophage synthesis of monokines and increased protein production, cell proliferation, and vascular permeability.

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    of 1

    GLOMERULAR BASEMENT MEMBRANE (90%) Glycosoaminoglycans (GAG) Polysaccharides+sialo proteins

    Glycosylation
    Increased cross link of Disulphide bridges

    Heparan sulphate - Basement

    Heparan Sulphate + Silalic Acid = Negative Charge in glomerular capillary wall

    Affects assembly and Architecture (Degradation) (Linear deposits of Albumin and IgB)

    Barrier for Charge Select -ive Properties Denovo Synthesis


    Reduction in Heparan Sulphate and Total GAG Content

    Reduced Degradation
    Accumulation and Expansion Of Mesangial Matrix and Glomelrular Base Membrane
    Membranous Receptor for Cross Linked Denatured Proteins

    Loss of Negative Charge

    Synthesis of macrophages of Monokines- Increased Protein Synthesis, cell proliferation and Vascular permeability

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